Trans-sialidase delivered as a naked DNA vaccine elicits an immunological response similar to a Trypanosoma cruzi infection
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1999 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| dARK ID: | ark:/48912/001300000nfr6 |
| DOI: | 10.1590/S0100-879X1999000200013 |
| Texto Completo: | http://dx.doi.org/10.1590/S0100-879X1999000200013 http://repositorio.unifesp.br/handle/11600/731 |
Resumo: | Trypanosoma cruzi, the protozoan parasite that causes Chagas' disease, does not synthesize sialic acid, but expresses a trans-sialidase (TS) that catalyzes the transfer of sialic acid from host glycoconjugates to the parasite surface. Here, we review studies that characterize the immune response to the catalytic domain of the enzyme in humans during Chagas' disease or in mice following immunization with the TS gene. In both cases, there are antibodies that strongly inhibit the enzymatic activity and generation of interferon-g-producing T cells. |
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Trans-sialidase delivered as a naked DNA vaccine elicits an immunological response similar to a Trypanosoma cruzi infectionDNA vaccinationTrans-sialidaseChagas' diseaseTrypanosoma cruzi, the protozoan parasite that causes Chagas' disease, does not synthesize sialic acid, but expresses a trans-sialidase (TS) that catalyzes the transfer of sialic acid from host glycoconjugates to the parasite surface. Here, we review studies that characterize the immune response to the catalytic domain of the enzyme in humans during Chagas' disease or in mice following immunization with the TS gene. In both cases, there are antibodies that strongly inhibit the enzymatic activity and generation of interferon-g-producing T cells.Universidade Federal de São Paulo (UNIFESP)Instituto Dante Pazzanese de Cardiologia do Estado de São PauloUNIFESPSciELOAssociação Brasileira de Divulgação CientíficaUniversidade Federal de São Paulo (UNIFESP)Instituto Dante Pazzanese de Cardiologia do Estado de São PauloCosta, F. [UNIFESP]Pereira-Chioccola, Vera Lucia [UNIFESP]Ribeirão, M. [UNIFESP]Schenkman, Sergio [UNIFESP]Rodrigues, Mauricio Martins [UNIFESP]2015-06-14T13:24:50Z2015-06-14T13:24:50Z1999-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://dx.doi.org/10.1590/S0100-879X1999000200013Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 2, p. -, 1999.10.1590/S0100-879X1999000200013S0100-879X1999000200013.pdf0100-879XS0100-879X1999000200013http://repositorio.unifesp.br/handle/11600/731WOS:000078745300013ark:/48912/001300000nfr6engBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-05T22:19:14Zoai:repositorio.unifesp.br/:11600/731Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:27:09.589506Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Trans-sialidase delivered as a naked DNA vaccine elicits an immunological response similar to a Trypanosoma cruzi infection |
| title |
Trans-sialidase delivered as a naked DNA vaccine elicits an immunological response similar to a Trypanosoma cruzi infection |
| spellingShingle |
Trans-sialidase delivered as a naked DNA vaccine elicits an immunological response similar to a Trypanosoma cruzi infection Trans-sialidase delivered as a naked DNA vaccine elicits an immunological response similar to a Trypanosoma cruzi infection Costa, F. [UNIFESP] DNA vaccination Trans-sialidase Chagas' disease Costa, F. [UNIFESP] DNA vaccination Trans-sialidase Chagas' disease |
| title_short |
Trans-sialidase delivered as a naked DNA vaccine elicits an immunological response similar to a Trypanosoma cruzi infection |
| title_full |
Trans-sialidase delivered as a naked DNA vaccine elicits an immunological response similar to a Trypanosoma cruzi infection |
| title_fullStr |
Trans-sialidase delivered as a naked DNA vaccine elicits an immunological response similar to a Trypanosoma cruzi infection Trans-sialidase delivered as a naked DNA vaccine elicits an immunological response similar to a Trypanosoma cruzi infection |
| title_full_unstemmed |
Trans-sialidase delivered as a naked DNA vaccine elicits an immunological response similar to a Trypanosoma cruzi infection Trans-sialidase delivered as a naked DNA vaccine elicits an immunological response similar to a Trypanosoma cruzi infection |
| title_sort |
Trans-sialidase delivered as a naked DNA vaccine elicits an immunological response similar to a Trypanosoma cruzi infection |
| author |
Costa, F. [UNIFESP] |
| author_facet |
Costa, F. [UNIFESP] Costa, F. [UNIFESP] Pereira-Chioccola, Vera Lucia [UNIFESP] Ribeirão, M. [UNIFESP] Schenkman, Sergio [UNIFESP] Rodrigues, Mauricio Martins [UNIFESP] Pereira-Chioccola, Vera Lucia [UNIFESP] Ribeirão, M. [UNIFESP] Schenkman, Sergio [UNIFESP] Rodrigues, Mauricio Martins [UNIFESP] |
| author_role |
author |
| author2 |
Pereira-Chioccola, Vera Lucia [UNIFESP] Ribeirão, M. [UNIFESP] Schenkman, Sergio [UNIFESP] Rodrigues, Mauricio Martins [UNIFESP] |
| author2_role |
author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Instituto Dante Pazzanese de Cardiologia do Estado de São Paulo |
| dc.contributor.author.fl_str_mv |
Costa, F. [UNIFESP] Pereira-Chioccola, Vera Lucia [UNIFESP] Ribeirão, M. [UNIFESP] Schenkman, Sergio [UNIFESP] Rodrigues, Mauricio Martins [UNIFESP] |
| dc.subject.por.fl_str_mv |
DNA vaccination Trans-sialidase Chagas' disease |
| topic |
DNA vaccination Trans-sialidase Chagas' disease |
| description |
Trypanosoma cruzi, the protozoan parasite that causes Chagas' disease, does not synthesize sialic acid, but expresses a trans-sialidase (TS) that catalyzes the transfer of sialic acid from host glycoconjugates to the parasite surface. Here, we review studies that characterize the immune response to the catalytic domain of the enzyme in humans during Chagas' disease or in mice following immunization with the TS gene. In both cases, there are antibodies that strongly inhibit the enzymatic activity and generation of interferon-g-producing T cells. |
| publishDate |
1999 |
| dc.date.none.fl_str_mv |
1999-02-01 2015-06-14T13:24:50Z 2015-06-14T13:24:50Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0100-879X1999000200013 Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 2, p. -, 1999. 10.1590/S0100-879X1999000200013 S0100-879X1999000200013.pdf 0100-879X S0100-879X1999000200013 http://repositorio.unifesp.br/handle/11600/731 WOS:000078745300013 |
| dc.identifier.dark.fl_str_mv |
ark:/48912/001300000nfr6 |
| url |
http://dx.doi.org/10.1590/S0100-879X1999000200013 http://repositorio.unifesp.br/handle/11600/731 |
| identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 2, p. -, 1999. 10.1590/S0100-879X1999000200013 S0100-879X1999000200013.pdf 0100-879X S0100-879X1999000200013 WOS:000078745300013 ark:/48912/001300000nfr6 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
| publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| instname_str |
Universidade Federal de São Paulo (UNIFESP) |
| instacron_str |
UNIFESP |
| institution |
UNIFESP |
| reponame_str |
Repositório Institucional da UNIFESP |
| collection |
Repositório Institucional da UNIFESP |
| repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
| repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
| _version_ |
1822183934675386368 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/S0100-879X1999000200013 |