Langerhans cell histiocytosis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1998 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| Texto Completo: | https://dx.doi.org/10.1590/S1516-31801998000100006 https://repositorio.unifesp.br/handle/11600/575 |
Resumo: | The authors present a rare case of Langerhans cell histiocytosis in a 31 year old female patient with vulvar, peri-anal and oral lesions, diabetes insipidus, pulmonary skin and bone infiltrations. Skin biopsy immunohistochemistry presented positive S100 protein and vimentine, but the diagnosis was done with the demonstration of Birbeck granules with eletronic mucroscopy. The treatment was based on systemical chemotherapy although vulvar lesion has a bad response to chemotherapy. |
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Langerhans cell histiocytosisHistiocytosis XLangerhans cellDiabetes insipidusThe authors present a rare case of Langerhans cell histiocytosis in a 31 year old female patient with vulvar, peri-anal and oral lesions, diabetes insipidus, pulmonary skin and bone infiltrations. Skin biopsy immunohistochemistry presented positive S100 protein and vimentine, but the diagnosis was done with the demonstration of Birbeck granules with eletronic mucroscopy. The treatment was based on systemical chemotherapy although vulvar lesion has a bad response to chemotherapy.Os autores apresentam um caso raro de histiocitose de célula de Langerhans com apresentação lentamente progressiva, lesão vulvar, peri-anal e oral, diabete insipidus, infiltração pulmonar, dérmica e óssea em paciente de 31 anos. A imunohistoquímica da biopsia de pele foi: proteína S-100 e vimentina positivas, porém o diagnóstico definitivo foi feito pela demonstração de grânulos de Birbeck à microscopia eletrônica. O tratamento baseia-se em quimioterapia sistêmica e a lesão vulvar tem má resposta à quimioterapia.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de MedicinaUNIFESP, EPMSciELOAssociação Paulista de Medicina - APMUniversidade Federal de São Paulo (UNIFESP)Chauffaille, Maria de Lourdes Lopes Ferrari [UNIFESP]Valério, Rosana Maria [UNIFESP]Diniz, Cybelle Maria Costa [UNIFESP]Enokihara, Mílvia Maria Simões e Silva [UNIFESP]Enokihara, Silva [UNIFESP]Michalany, Nylceo [UNIFESP]Ferreira, Karin Ventura [UNIFESP]Martinez, José Antônio Baddini [UNIFESP]Hassun, Karine Marques [UNIFESP]Atallah, Álvaro Nagib [UNIFESP]Kerbauy, José [UNIFESP]2015-06-14T13:24:41Z2015-06-14T13:24:41Z1998-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1625-1628application/pdfhttps://dx.doi.org/10.1590/S1516-31801998000100006São Paulo Medical Journal. Associação Paulista de Medicina - APM, v. 116, n. 1, p. 1625-1628, 1998.10.1590/S1516-31801998000100006S1516-31801998000100006.pdf1516-3180S1516-31801998000100006https://repositorio.unifesp.br/handle/11600/575engSão Paulo Medical Journalinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-30T00:39:30Zoai:repositorio.unifesp.br/:11600/575Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-30T00:39:30Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Langerhans cell histiocytosis |
| title |
Langerhans cell histiocytosis |
| spellingShingle |
Langerhans cell histiocytosis Chauffaille, Maria de Lourdes Lopes Ferrari [UNIFESP] Histiocytosis X Langerhans cell Diabetes insipidus |
| title_short |
Langerhans cell histiocytosis |
| title_full |
Langerhans cell histiocytosis |
| title_fullStr |
Langerhans cell histiocytosis |
| title_full_unstemmed |
Langerhans cell histiocytosis |
| title_sort |
Langerhans cell histiocytosis |
| author |
Chauffaille, Maria de Lourdes Lopes Ferrari [UNIFESP] |
| author_facet |
Chauffaille, Maria de Lourdes Lopes Ferrari [UNIFESP] Valério, Rosana Maria [UNIFESP] Diniz, Cybelle Maria Costa [UNIFESP] Enokihara, Mílvia Maria Simões e Silva [UNIFESP] Enokihara, Silva [UNIFESP] Michalany, Nylceo [UNIFESP] Ferreira, Karin Ventura [UNIFESP] Martinez, José Antônio Baddini [UNIFESP] Hassun, Karine Marques [UNIFESP] Atallah, Álvaro Nagib [UNIFESP] Kerbauy, José [UNIFESP] |
| author_role |
author |
| author2 |
Valério, Rosana Maria [UNIFESP] Diniz, Cybelle Maria Costa [UNIFESP] Enokihara, Mílvia Maria Simões e Silva [UNIFESP] Enokihara, Silva [UNIFESP] Michalany, Nylceo [UNIFESP] Ferreira, Karin Ventura [UNIFESP] Martinez, José Antônio Baddini [UNIFESP] Hassun, Karine Marques [UNIFESP] Atallah, Álvaro Nagib [UNIFESP] Kerbauy, José [UNIFESP] |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
| dc.contributor.author.fl_str_mv |
Chauffaille, Maria de Lourdes Lopes Ferrari [UNIFESP] Valério, Rosana Maria [UNIFESP] Diniz, Cybelle Maria Costa [UNIFESP] Enokihara, Mílvia Maria Simões e Silva [UNIFESP] Enokihara, Silva [UNIFESP] Michalany, Nylceo [UNIFESP] Ferreira, Karin Ventura [UNIFESP] Martinez, José Antônio Baddini [UNIFESP] Hassun, Karine Marques [UNIFESP] Atallah, Álvaro Nagib [UNIFESP] Kerbauy, José [UNIFESP] |
| dc.subject.por.fl_str_mv |
Histiocytosis X Langerhans cell Diabetes insipidus |
| topic |
Histiocytosis X Langerhans cell Diabetes insipidus |
| description |
The authors present a rare case of Langerhans cell histiocytosis in a 31 year old female patient with vulvar, peri-anal and oral lesions, diabetes insipidus, pulmonary skin and bone infiltrations. Skin biopsy immunohistochemistry presented positive S100 protein and vimentine, but the diagnosis was done with the demonstration of Birbeck granules with eletronic mucroscopy. The treatment was based on systemical chemotherapy although vulvar lesion has a bad response to chemotherapy. |
| publishDate |
1998 |
| dc.date.none.fl_str_mv |
1998-02-01 2015-06-14T13:24:41Z 2015-06-14T13:24:41Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://dx.doi.org/10.1590/S1516-31801998000100006 São Paulo Medical Journal. Associação Paulista de Medicina - APM, v. 116, n. 1, p. 1625-1628, 1998. 10.1590/S1516-31801998000100006 S1516-31801998000100006.pdf 1516-3180 S1516-31801998000100006 https://repositorio.unifesp.br/handle/11600/575 |
| url |
https://dx.doi.org/10.1590/S1516-31801998000100006 https://repositorio.unifesp.br/handle/11600/575 |
| identifier_str_mv |
São Paulo Medical Journal. Associação Paulista de Medicina - APM, v. 116, n. 1, p. 1625-1628, 1998. 10.1590/S1516-31801998000100006 S1516-31801998000100006.pdf 1516-3180 S1516-31801998000100006 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
São Paulo Medical Journal |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
1625-1628 application/pdf |
| dc.publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
| publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| instname_str |
Universidade Federal de São Paulo (UNIFESP) |
| instacron_str |
UNIFESP |
| institution |
UNIFESP |
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Repositório Institucional da UNIFESP |
| collection |
Repositório Institucional da UNIFESP |
| repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
| repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1814268419021733888 |