Bone turnover assessment: a good surrogate marker?

Detalhes bibliográficos
Autor(a) principal: Dreyer, Patrícia [UNIFESP]
Data de Publicação: 2010
Outros Autores: Vieira, José Gilberto H. [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0004-27302010000200003
http://repositorio.unifesp.br/handle/11600/5630
Resumo: To asses fracture risk, bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) is the most commonly used tool. The search for clinical risk factors is also advised and can provide a 10-year fracture probability (FRAX model). Another important determinant of bone strength is bone remodeling. High bone remodeling rates have been associated with a higher fracture risk and bone turnover markers (BTM) may offer dynamic information about skeletal status independent of BMD. The efficacy of antiresorptive agents in fracture prevention goes beyond what can be predicted by BMD especially in the beginning of the treatment. Inhibition of bone remodeling itself is certainly an important mechanism by which antiresorptive agents can rapidly reduce fracture risk. Thus, it seems quite logical to use BTM in patients with bone disease. It can also become a valuable surrogate marker in fracture prediction. However, BTM's pre-analytical and analytical variability should always be considered.
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spelling Bone turnover assessment: a good surrogate marker?Avaliação da remodelação óssea: um bom marcador substituto?Bone turnoverbiochemical markersosteoporosisfractureRemodelação ósseamarcadores ósseososteoporosefraturaTo asses fracture risk, bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) is the most commonly used tool. The search for clinical risk factors is also advised and can provide a 10-year fracture probability (FRAX model). Another important determinant of bone strength is bone remodeling. High bone remodeling rates have been associated with a higher fracture risk and bone turnover markers (BTM) may offer dynamic information about skeletal status independent of BMD. The efficacy of antiresorptive agents in fracture prevention goes beyond what can be predicted by BMD especially in the beginning of the treatment. Inhibition of bone remodeling itself is certainly an important mechanism by which antiresorptive agents can rapidly reduce fracture risk. Thus, it seems quite logical to use BTM in patients with bone disease. It can also become a valuable surrogate marker in fracture prediction. However, BTM's pre-analytical and analytical variability should always be considered.O método mais utilizado para avaliação do risco de fraturas é a densitometria óssea pela técnica de DXA (absorciometria por raios-X duo-energética). A pesquisa de condições clínicas de risco também é recomendada e fornece uma estimativa da probabilidade de fratura em 10 anos (modelo FRAX). Outro fator importante é o grau de remodelação óssea. Um aumento da taxa de remodelação tem sido associado a um maior risco de fraturas e aumento dos marcadores ósseos. A medida desses marcadores fornece informação adicional independente da densitometria. A eficiência das medicações antirreabsortivas na prevenção de fraturas não é explicada apenas pelo aumento da densidade óssea. A menor remodelação óssea é um mecanismo que pode explicar a redução da taxa de fraturas principalmente no início do tratamento. A utilização desses marcadores nas doenças ósseas e na predição de fraturas torna-se lógica. No entanto, para interpretá-los corretamente sua variação pré-analítica e analítica deve ser considerada.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Unidade de Metabolismo Ósseo e MineralUNIFESP, EPM, Unidade de Metabolismo Ósseo e MineralSciELOSociedade Brasileira de Endocrinologia e MetabologiaUniversidade Federal de São Paulo (UNIFESP)Dreyer, Patrícia [UNIFESP]Vieira, José Gilberto H. [UNIFESP]2015-06-14T13:41:34Z2015-06-14T13:41:34Z2010-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion99-105application/pdfhttp://dx.doi.org/10.1590/S0004-27302010000200003Arquivos Brasileiros de Endocrinologia & Metabologia. Sociedade Brasileira de Endocrinologia e Metabologia, v. 54, n. 2, p. 99-105, 2010.10.1590/S0004-27302010000200003S0004-27302010000200003.pdf0004-2730S0004-27302010000200003http://repositorio.unifesp.br/handle/11600/5630WOS:000277526000003engArquivos Brasileiros de Endocrinologia & Metabologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-28T19:17:52Zoai:repositorio.unifesp.br/:11600/5630Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-28T19:17:52Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Bone turnover assessment: a good surrogate marker?
Avaliação da remodelação óssea: um bom marcador substituto?
title Bone turnover assessment: a good surrogate marker?
spellingShingle Bone turnover assessment: a good surrogate marker?
Dreyer, Patrícia [UNIFESP]
Bone turnover
biochemical markers
osteoporosis
fracture
Remodelação óssea
marcadores ósseos
osteoporose
fratura
title_short Bone turnover assessment: a good surrogate marker?
title_full Bone turnover assessment: a good surrogate marker?
title_fullStr Bone turnover assessment: a good surrogate marker?
title_full_unstemmed Bone turnover assessment: a good surrogate marker?
title_sort Bone turnover assessment: a good surrogate marker?
author Dreyer, Patrícia [UNIFESP]
author_facet Dreyer, Patrícia [UNIFESP]
Vieira, José Gilberto H. [UNIFESP]
author_role author
author2 Vieira, José Gilberto H. [UNIFESP]
author2_role author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Dreyer, Patrícia [UNIFESP]
Vieira, José Gilberto H. [UNIFESP]
dc.subject.por.fl_str_mv Bone turnover
biochemical markers
osteoporosis
fracture
Remodelação óssea
marcadores ósseos
osteoporose
fratura
topic Bone turnover
biochemical markers
osteoporosis
fracture
Remodelação óssea
marcadores ósseos
osteoporose
fratura
description To asses fracture risk, bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) is the most commonly used tool. The search for clinical risk factors is also advised and can provide a 10-year fracture probability (FRAX model). Another important determinant of bone strength is bone remodeling. High bone remodeling rates have been associated with a higher fracture risk and bone turnover markers (BTM) may offer dynamic information about skeletal status independent of BMD. The efficacy of antiresorptive agents in fracture prevention goes beyond what can be predicted by BMD especially in the beginning of the treatment. Inhibition of bone remodeling itself is certainly an important mechanism by which antiresorptive agents can rapidly reduce fracture risk. Thus, it seems quite logical to use BTM in patients with bone disease. It can also become a valuable surrogate marker in fracture prediction. However, BTM's pre-analytical and analytical variability should always be considered.
publishDate 2010
dc.date.none.fl_str_mv 2010-03-01
2015-06-14T13:41:34Z
2015-06-14T13:41:34Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0004-27302010000200003
Arquivos Brasileiros de Endocrinologia & Metabologia. Sociedade Brasileira de Endocrinologia e Metabologia, v. 54, n. 2, p. 99-105, 2010.
10.1590/S0004-27302010000200003
S0004-27302010000200003.pdf
0004-2730
S0004-27302010000200003
http://repositorio.unifesp.br/handle/11600/5630
WOS:000277526000003
url http://dx.doi.org/10.1590/S0004-27302010000200003
http://repositorio.unifesp.br/handle/11600/5630
identifier_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia. Sociedade Brasileira de Endocrinologia e Metabologia, v. 54, n. 2, p. 99-105, 2010.
10.1590/S0004-27302010000200003
S0004-27302010000200003.pdf
0004-2730
S0004-27302010000200003
WOS:000277526000003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 99-105
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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