Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: Spectrum of antimicrobial activity and measurements of bactericidal activity

Detalhes bibliográficos
Autor(a) principal: Sader, Helio S. [UNIFESP]
Data de Publicação: 2004
Outros Autores: Fedler, Kelley A., Rennie, Robert P., Stevens, Shelley, Jones, Ronald N.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://repositorio.unifesp.br/handle/11600/27844
http://dx.doi.org/10.1128/AAC.48.8.312-3118.2004
Resumo: The activity of omiganan pentahydrochloride (formerly MBI 226; a synthetic cationic peptide) was assessed against 1,437 recent clinical bacterial isolates and 214 recent clinical yeast isolates. the omiganan was highly active, and minimal bactericidal concentrations or minimal fungicidal concentrations were either equal to or two- to fourfold higher than MICs. Kill curve experiments showed a clear pattern of bactericidal activity.
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spelling Sader, Helio S. [UNIFESP]Fedler, Kelley A.Rennie, Robert P.Stevens, ShelleyJones, Ronald N.JMI LabsUniversidade Federal de São Paulo (UNIFESP)Univ Alberta Hosp2016-01-24T12:37:16Z2016-01-24T12:37:16Z2004-08-01Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 48, n. 8, p. 3112-3118, 2004.0066-4804http://repositorio.unifesp.br/handle/11600/27844http://dx.doi.org/10.1128/AAC.48.8.312-3118.2004WOS000222998300047.pdf10.1128/AAC.48.8.312-3118.2004WOS:000222998300047The activity of omiganan pentahydrochloride (formerly MBI 226; a synthetic cationic peptide) was assessed against 1,437 recent clinical bacterial isolates and 214 recent clinical yeast isolates. the omiganan was highly active, and minimal bactericidal concentrations or minimal fungicidal concentrations were either equal to or two- to fourfold higher than MICs. Kill curve experiments showed a clear pattern of bactericidal activity.JMI Labs, Jones Grp, N Liberty, IA 52317 USAUniversidade Federal de São Paulo, São Paulo, BrazilUniv Alberta Hosp, Edmonton, AB T6G 2B7, CanadaUniversidade Federal de São Paulo, EPM, São Paulo, BrazilWeb of Science3112-3118engAmer Soc MicrobiologyAntimicrobial Agents and ChemotherapyOmiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: Spectrum of antimicrobial activity and measurements of bactericidal activityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000222998300047.pdfapplication/pdf57727${dspace.ui.url}/bitstream/11600/27844/1/WOS000222998300047.pdfc8161fe64e89e5bfdb60141a3d3479fdMD51open accessTEXTWOS000222998300047.pdf.txtWOS000222998300047.pdf.txtExtracted texttext/plain27462${dspace.ui.url}/bitstream/11600/27844/2/WOS000222998300047.pdf.txtfef31a33f005b37a85dc2c1728b2a9a3MD52open access11600/278442022-11-04 14:18:49.673open accessoai:repositorio.unifesp.br:11600/27844Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-11-04T17:18:49Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.en.fl_str_mv Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: Spectrum of antimicrobial activity and measurements of bactericidal activity
title Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: Spectrum of antimicrobial activity and measurements of bactericidal activity
spellingShingle Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: Spectrum of antimicrobial activity and measurements of bactericidal activity
Sader, Helio S. [UNIFESP]
title_short Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: Spectrum of antimicrobial activity and measurements of bactericidal activity
title_full Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: Spectrum of antimicrobial activity and measurements of bactericidal activity
title_fullStr Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: Spectrum of antimicrobial activity and measurements of bactericidal activity
title_full_unstemmed Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: Spectrum of antimicrobial activity and measurements of bactericidal activity
title_sort Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: Spectrum of antimicrobial activity and measurements of bactericidal activity
author Sader, Helio S. [UNIFESP]
author_facet Sader, Helio S. [UNIFESP]
Fedler, Kelley A.
Rennie, Robert P.
Stevens, Shelley
Jones, Ronald N.
author_role author
author2 Fedler, Kelley A.
Rennie, Robert P.
Stevens, Shelley
Jones, Ronald N.
author2_role author
author
author
author
dc.contributor.institution.none.fl_str_mv JMI Labs
Universidade Federal de São Paulo (UNIFESP)
Univ Alberta Hosp
dc.contributor.author.fl_str_mv Sader, Helio S. [UNIFESP]
Fedler, Kelley A.
Rennie, Robert P.
Stevens, Shelley
Jones, Ronald N.
description The activity of omiganan pentahydrochloride (formerly MBI 226; a synthetic cationic peptide) was assessed against 1,437 recent clinical bacterial isolates and 214 recent clinical yeast isolates. the omiganan was highly active, and minimal bactericidal concentrations or minimal fungicidal concentrations were either equal to or two- to fourfold higher than MICs. Kill curve experiments showed a clear pattern of bactericidal activity.
publishDate 2004
dc.date.issued.fl_str_mv 2004-08-01
dc.date.accessioned.fl_str_mv 2016-01-24T12:37:16Z
dc.date.available.fl_str_mv 2016-01-24T12:37:16Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 48, n. 8, p. 3112-3118, 2004.
dc.identifier.uri.fl_str_mv http://repositorio.unifesp.br/handle/11600/27844
http://dx.doi.org/10.1128/AAC.48.8.312-3118.2004
dc.identifier.issn.none.fl_str_mv 0066-4804
dc.identifier.file.none.fl_str_mv WOS000222998300047.pdf
dc.identifier.doi.none.fl_str_mv 10.1128/AAC.48.8.312-3118.2004
dc.identifier.wos.none.fl_str_mv WOS:000222998300047
identifier_str_mv Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 48, n. 8, p. 3112-3118, 2004.
0066-4804
WOS000222998300047.pdf
10.1128/AAC.48.8.312-3118.2004
WOS:000222998300047
url http://repositorio.unifesp.br/handle/11600/27844
http://dx.doi.org/10.1128/AAC.48.8.312-3118.2004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Antimicrobial Agents and Chemotherapy
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 3112-3118
dc.publisher.none.fl_str_mv Amer Soc Microbiology
publisher.none.fl_str_mv Amer Soc Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
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