Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosa
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| dARK ID: | ark:/48912/00130000032t5 |
| DOI: | 10.1186/1916-0216-42-29 |
| Texto Completo: | http://dx.doi.org/10.1186/1916-0216-42-29 http://repositorio.unifesp.br/handle/11600/36209 |
Resumo: | Objective: To evaluate TGF-beta(1) expression in polypoid mucosa (epithelium and stroma) of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP).Methods: Cross-sectional study with two groups: 17 patients with nasal polyposis and 11 controls. Polyps and normal nasal mucosa were processed by immunohistochemical methods for TGF-beta 1 visualization. Then, the percentage of TGF-beta 1 expression in stroma and epithelium was objectively quantified using UT Morph software.Results: A lower percentage of positive expression was found in the epithelium of CRSwNP patients (32.44%) versus normal controls (55.91%) (p < 0.05), and a higher percentage of positive expression in the stroma of CRSwNP patients (23.24%) versus controls (5.88%) (p < 0.05).Conclusion: the lower percentage of TGF-beta(1) expression in the nasal epithelium of CRSwNP patients may have an impact on epithelium-directed topical treatments employed in this patient population. |
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Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosaTGF-beta 1Nasal polypsRhinosinusitisMucosaObjective: To evaluate TGF-beta(1) expression in polypoid mucosa (epithelium and stroma) of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP).Methods: Cross-sectional study with two groups: 17 patients with nasal polyposis and 11 controls. Polyps and normal nasal mucosa were processed by immunohistochemical methods for TGF-beta 1 visualization. Then, the percentage of TGF-beta 1 expression in stroma and epithelium was objectively quantified using UT Morph software.Results: A lower percentage of positive expression was found in the epithelium of CRSwNP patients (32.44%) versus normal controls (55.91%) (p < 0.05), and a higher percentage of positive expression in the stroma of CRSwNP patients (23.24%) versus controls (5.88%) (p < 0.05).Conclusion: the lower percentage of TGF-beta(1) expression in the nasal epithelium of CRSwNP patients may have an impact on epithelium-directed topical treatments employed in this patient population.Universidade Federal de São Paulo, Dept Otolaryngol Head & Neck Surg, São Paulo, BrazilUniv Ghent, Ghent Univ Hosp, Dept Otorhinolaryngol, Upper Airway Res Lab, B-9000 Ghent, BelgiumUniversidade Federal de São Paulo, Dept Pathol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Otolaryngol Head & Neck Surg, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Pathol, São Paulo, BrazilWeb of ScienceBiomed Central LtdUniversidade Federal de São Paulo (UNIFESP)Univ GhentBalsalobre, Leonardo [UNIFESP]Pezato, Rogerio [UNIFESP]Perez-Novo, ClaudinaAlves, Maria Teresa S. [UNIFESP]Santos, Rodrigo P. [UNIFESP]Bachert, ClausWeckx, Luc L. M. [UNIFESP]2016-01-24T14:31:35Z2016-01-24T14:31:35Z2013-04-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion5application/pdfhttp://dx.doi.org/10.1186/1916-0216-42-29Journal of Otolaryngology-head & Neck Surgery. London: Biomed Central Ltd, v. 42, 5 p., 2013.10.1186/1916-0216-42-29WOS000318410400001.pdf1916-0216http://repositorio.unifesp.br/handle/11600/36209WOS:000318410400001ark:/48912/00130000032t5engJournal of Otolaryngology-head & Neck Surgeryinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-30T13:44:48Zoai:repositorio.unifesp.br/:11600/36209Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T19:54:00.097588Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosa |
| title |
Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosa |
| spellingShingle |
Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosa Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosa Balsalobre, Leonardo [UNIFESP] TGF-beta 1 Nasal polyps Rhinosinusitis Mucosa Balsalobre, Leonardo [UNIFESP] TGF-beta 1 Nasal polyps Rhinosinusitis Mucosa |
| title_short |
Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosa |
| title_full |
Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosa |
| title_fullStr |
Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosa Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosa |
| title_full_unstemmed |
Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosa Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosa |
| title_sort |
Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosa |
| author |
Balsalobre, Leonardo [UNIFESP] |
| author_facet |
Balsalobre, Leonardo [UNIFESP] Balsalobre, Leonardo [UNIFESP] Pezato, Rogerio [UNIFESP] Perez-Novo, Claudina Alves, Maria Teresa S. [UNIFESP] Santos, Rodrigo P. [UNIFESP] Bachert, Claus Weckx, Luc L. M. [UNIFESP] Pezato, Rogerio [UNIFESP] Perez-Novo, Claudina Alves, Maria Teresa S. [UNIFESP] Santos, Rodrigo P. [UNIFESP] Bachert, Claus Weckx, Luc L. M. [UNIFESP] |
| author_role |
author |
| author2 |
Pezato, Rogerio [UNIFESP] Perez-Novo, Claudina Alves, Maria Teresa S. [UNIFESP] Santos, Rodrigo P. [UNIFESP] Bachert, Claus Weckx, Luc L. M. [UNIFESP] |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Univ Ghent |
| dc.contributor.author.fl_str_mv |
Balsalobre, Leonardo [UNIFESP] Pezato, Rogerio [UNIFESP] Perez-Novo, Claudina Alves, Maria Teresa S. [UNIFESP] Santos, Rodrigo P. [UNIFESP] Bachert, Claus Weckx, Luc L. M. [UNIFESP] |
| dc.subject.por.fl_str_mv |
TGF-beta 1 Nasal polyps Rhinosinusitis Mucosa |
| topic |
TGF-beta 1 Nasal polyps Rhinosinusitis Mucosa |
| description |
Objective: To evaluate TGF-beta(1) expression in polypoid mucosa (epithelium and stroma) of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP).Methods: Cross-sectional study with two groups: 17 patients with nasal polyposis and 11 controls. Polyps and normal nasal mucosa were processed by immunohistochemical methods for TGF-beta 1 visualization. Then, the percentage of TGF-beta 1 expression in stroma and epithelium was objectively quantified using UT Morph software.Results: A lower percentage of positive expression was found in the epithelium of CRSwNP patients (32.44%) versus normal controls (55.91%) (p < 0.05), and a higher percentage of positive expression in the stroma of CRSwNP patients (23.24%) versus controls (5.88%) (p < 0.05).Conclusion: the lower percentage of TGF-beta(1) expression in the nasal epithelium of CRSwNP patients may have an impact on epithelium-directed topical treatments employed in this patient population. |
| publishDate |
2013 |
| dc.date.none.fl_str_mv |
2013-04-15 2016-01-24T14:31:35Z 2016-01-24T14:31:35Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/1916-0216-42-29 Journal of Otolaryngology-head & Neck Surgery. London: Biomed Central Ltd, v. 42, 5 p., 2013. 10.1186/1916-0216-42-29 WOS000318410400001.pdf 1916-0216 http://repositorio.unifesp.br/handle/11600/36209 WOS:000318410400001 |
| dc.identifier.dark.fl_str_mv |
ark:/48912/00130000032t5 |
| url |
http://dx.doi.org/10.1186/1916-0216-42-29 http://repositorio.unifesp.br/handle/11600/36209 |
| identifier_str_mv |
Journal of Otolaryngology-head & Neck Surgery. London: Biomed Central Ltd, v. 42, 5 p., 2013. 10.1186/1916-0216-42-29 WOS000318410400001.pdf 1916-0216 WOS:000318410400001 ark:/48912/00130000032t5 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Journal of Otolaryngology-head & Neck Surgery |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
5 application/pdf |
| dc.publisher.none.fl_str_mv |
Biomed Central Ltd |
| publisher.none.fl_str_mv |
Biomed Central Ltd |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| instname_str |
Universidade Federal de São Paulo (UNIFESP) |
| instacron_str |
UNIFESP |
| institution |
UNIFESP |
| reponame_str |
Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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biblioteca.csp@unifesp.br |
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1822183953566531584 |
| dc.identifier.doi.none.fl_str_mv |
10.1186/1916-0216-42-29 |