Chromosome X Aneuploidy in Brazilian Schizophrenic Patients

• Autor(a) principal: De Moraes, Leopoldo Silva
• Data de Publicação: 2010
• Outros Autores: Khayat, Andre Salim [UNIFESP], Lima De Lima, Patricia Danielle, Lima, Eleonidas Moura, Pinto, Giovanny Reboucas, Leal, Mariana Ferreira [UNIFESP], Smith, Marilia de Arruda Cardoso [UNIFESP], Burbano, Rommel Rodriguez [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://iv.iiarjournals.org/content/24/3/281.long; http://repositorio.unifesp.br/handle/11600/43914
• topic: Aneuploidy; chromosome X; GTG-banding; fluorescence in situ hybridization; schizophrenia

The identification of cytogenetic abnormalities in schizophrenic patients may provide clues to the genes involved in this disease. For this reason, a chromosomal analysis of samples from 62 schizophrenics and 70 controls was performed with trypsin-Giemsa banding and fluorescence in situ hybridization of the X chromosome. A clonal pericentric inversion on chromosome 9 was detected in one male patient, and we also discovered mosaicism associated with X chromosome aneuploidy in female patients, primarily detected in schizophrenic and normal female controls over 40 years old. When compared with age-matched female controls, the frequency of X chromosome loss was not significantly different between schizophrenics and controls, except for the 40- to 49-year-old age group. Our findings suggest that the X chromosome loss seen in schizophrenic patients is inherent to the normal cellular aging process. However, our data also suggest that X chromosome gain may he correlated with schizophrenia in this Brazilian population.