Lactate detection by MRS in mitochondrial encephalopathy: Optimization of technical parameters
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/30235 http://dx.doi.org/10.1111/j.1552-6569.2007.00205.x |
Resumo: | Mitochondriopathies are a heterogeneous group of diseases with variable phenotypic presentation, which can range from subclinical to lethal forms. They are related either to DNA mutations or nuclear-encoded mitochondrial genes that affect the integrity and function of these organelles, compromising adenosine triphosphate (ATP) synthesis. Magnetic resonance (MR) is the most important imaging technique to detect structural and metabolic brain abnormalities in mitochondriopathies, although in some cases these studies may present normal results, or the identified brain abnormalities may be nonspecific. Magnetic resonance spectroscopy (MRS) enables the detection of high cerebral lactate levels, even when the brain has normal appearance by conventional MR scans. MRS is a useful tool for the diagnosis of mitochondriopathies, but must be correlated with clinical, neurophysiological, biochemical, histological, and molecular data to corroborate the diagnosis. Our aim is to clarify the most relevant issues related to the use of MRS in order to optimize its technical parameters, improving its use in the diagnosis of mitochondriopathies, which is often a challenge. |
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Rocha, Antonio Jose daBraga, Flavio TulioMaia Junior, Antonio Carlos Martins [UNIFESP]Silva, Carlos Jorge daToyama, CarlosPinto Gama, Hugo PereiraKok, Fernando [UNIFESP]Gomes, Helio Rodrigues [UNIFESP]Universidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)Fleury Diagnost Ctr2016-01-24T13:49:18Z2016-01-24T13:49:18Z2008-01-01Journal of Neuroimaging. Oxford: Blackwell Publishing, v. 18, n. 1, p. 1-8, 2008.1051-2284http://repositorio.unifesp.br/handle/11600/30235http://dx.doi.org/10.1111/j.1552-6569.2007.00205.x10.1111/j.1552-6569.2007.00205.xWOS:000252209600001Mitochondriopathies are a heterogeneous group of diseases with variable phenotypic presentation, which can range from subclinical to lethal forms. They are related either to DNA mutations or nuclear-encoded mitochondrial genes that affect the integrity and function of these organelles, compromising adenosine triphosphate (ATP) synthesis. Magnetic resonance (MR) is the most important imaging technique to detect structural and metabolic brain abnormalities in mitochondriopathies, although in some cases these studies may present normal results, or the identified brain abnormalities may be nonspecific. Magnetic resonance spectroscopy (MRS) enables the detection of high cerebral lactate levels, even when the brain has normal appearance by conventional MR scans. MRS is a useful tool for the diagnosis of mitochondriopathies, but must be correlated with clinical, neurophysiological, biochemical, histological, and molecular data to corroborate the diagnosis. Our aim is to clarify the most relevant issues related to the use of MRS in order to optimize its technical parameters, improving its use in the diagnosis of mitochondriopathies, which is often a challenge.Santa Casa São Paulo, Fac Med Sci, Dept Radiol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Neurol, São Paulo, BrazilUniv São Paulo, Dept Radiol, São Paulo, BrazilFleury Diagnost Ctr, Sect Innate Metab Disorders, São Paulo, BrazilFleury Diagnost Ctr, Sect Cerebrospinal Fluid, São Paulo, BrazilFleury Diagnost Ctr, Sect Radiol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Neurol, São Paulo, BrazilWeb of Science1-8engBlackwell PublishingJournal of Neuroimagingmitochondrial disorderslactatemagnetic resonance spectroscopyLactate detection by MRS in mitochondrial encephalopathy: Optimization of technical parametersinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/302352023-01-12 22:12:03.883metadata only accessoai:repositorio.unifesp.br:11600/30235Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:30:19.137796Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Lactate detection by MRS in mitochondrial encephalopathy: Optimization of technical parameters |
title |
Lactate detection by MRS in mitochondrial encephalopathy: Optimization of technical parameters |
spellingShingle |
Lactate detection by MRS in mitochondrial encephalopathy: Optimization of technical parameters Rocha, Antonio Jose da mitochondrial disorders lactate magnetic resonance spectroscopy |
title_short |
Lactate detection by MRS in mitochondrial encephalopathy: Optimization of technical parameters |
title_full |
Lactate detection by MRS in mitochondrial encephalopathy: Optimization of technical parameters |
title_fullStr |
Lactate detection by MRS in mitochondrial encephalopathy: Optimization of technical parameters |
title_full_unstemmed |
Lactate detection by MRS in mitochondrial encephalopathy: Optimization of technical parameters |
title_sort |
Lactate detection by MRS in mitochondrial encephalopathy: Optimization of technical parameters |
author |
Rocha, Antonio Jose da |
author_facet |
Rocha, Antonio Jose da Braga, Flavio Tulio Maia Junior, Antonio Carlos Martins [UNIFESP] Silva, Carlos Jorge da Toyama, Carlos Pinto Gama, Hugo Pereira Kok, Fernando [UNIFESP] Gomes, Helio Rodrigues [UNIFESP] |
author_role |
author |
author2 |
Braga, Flavio Tulio Maia Junior, Antonio Carlos Martins [UNIFESP] Silva, Carlos Jorge da Toyama, Carlos Pinto Gama, Hugo Pereira Kok, Fernando [UNIFESP] Gomes, Helio Rodrigues [UNIFESP] |
author2_role |
author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Federal de São Paulo (UNIFESP) Fleury Diagnost Ctr |
dc.contributor.author.fl_str_mv |
Rocha, Antonio Jose da Braga, Flavio Tulio Maia Junior, Antonio Carlos Martins [UNIFESP] Silva, Carlos Jorge da Toyama, Carlos Pinto Gama, Hugo Pereira Kok, Fernando [UNIFESP] Gomes, Helio Rodrigues [UNIFESP] |
dc.subject.eng.fl_str_mv |
mitochondrial disorders lactate magnetic resonance spectroscopy |
topic |
mitochondrial disorders lactate magnetic resonance spectroscopy |
description |
Mitochondriopathies are a heterogeneous group of diseases with variable phenotypic presentation, which can range from subclinical to lethal forms. They are related either to DNA mutations or nuclear-encoded mitochondrial genes that affect the integrity and function of these organelles, compromising adenosine triphosphate (ATP) synthesis. Magnetic resonance (MR) is the most important imaging technique to detect structural and metabolic brain abnormalities in mitochondriopathies, although in some cases these studies may present normal results, or the identified brain abnormalities may be nonspecific. Magnetic resonance spectroscopy (MRS) enables the detection of high cerebral lactate levels, even when the brain has normal appearance by conventional MR scans. MRS is a useful tool for the diagnosis of mitochondriopathies, but must be correlated with clinical, neurophysiological, biochemical, histological, and molecular data to corroborate the diagnosis. Our aim is to clarify the most relevant issues related to the use of MRS in order to optimize its technical parameters, improving its use in the diagnosis of mitochondriopathies, which is often a challenge. |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008-01-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T13:49:18Z |
dc.date.available.fl_str_mv |
2016-01-24T13:49:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Journal of Neuroimaging. Oxford: Blackwell Publishing, v. 18, n. 1, p. 1-8, 2008. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/30235 http://dx.doi.org/10.1111/j.1552-6569.2007.00205.x |
dc.identifier.issn.none.fl_str_mv |
1051-2284 |
dc.identifier.doi.none.fl_str_mv |
10.1111/j.1552-6569.2007.00205.x |
dc.identifier.wos.none.fl_str_mv |
WOS:000252209600001 |
identifier_str_mv |
Journal of Neuroimaging. Oxford: Blackwell Publishing, v. 18, n. 1, p. 1-8, 2008. 1051-2284 10.1111/j.1552-6569.2007.00205.x WOS:000252209600001 |
url |
http://repositorio.unifesp.br/handle/11600/30235 http://dx.doi.org/10.1111/j.1552-6569.2007.00205.x |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Journal of Neuroimaging |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1-8 |
dc.publisher.none.fl_str_mv |
Blackwell Publishing |
publisher.none.fl_str_mv |
Blackwell Publishing |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1783460299871879168 |