Perfil cardiovascular em pacientes com apneia obstrutiva do sono

• Autor(a) principal: Cintra, Fátima Dumas [UNIFESP]
• Data de Publicação: 2011
• Outros Autores: Tufik, Sergio [UNIFESP], De Paola, Angelo Amato Vincenzo [UNIFESP], Feres, Márcia Cristina [UNIFESP], Melo-fujita, Luciane [UNIFESP], Oliveira, Wercules [UNIFESP], Rizzi, Camila [UNIFESP], Poyares, Dalva [UNIFESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S0066-782X2011005000030; http://repositorio.unifesp.br/handle/11600/6397
• topic: Sleep apnea, obstructive; obesity; hypertension; dyslipidemia; Apneia do sono tipo obstrutiva; obesidade; hipertensão; dislipidemia

BACKGROUND: Obstructive Sleep Apnea (OSA) is a risk factor for several cardiovascular conditions including increased cardiovascular mortality. It is therefore essential to know the major cardiovascular effects of sleep-disordered breathing during a clinical evaluation. OBJECTIVE: To analyze the cardiovascular characteristics of patients with OSA. METHODS: Patients underwent baseline polysomnography and were consecutively selected from the database of the Sleep Institute between March 2007 and March 2009. All patients were instructed to attend the clinic for blood collection, physical examination, 12-lead electrocardiogram, spirometry, cardiopulmonary exercise testing on a treadmill and transthoracic echocardiography. The study was approved by the Research Ethics Committee and recorded at http://clinicaltrials.gov/ under number: NCT00768625. RESULTS: We analyzed 261 patients and 108 controls. The main characteristics of patients with OSA were: obesity, hypertension, low plasma levels of high density lipoprotein (HDL) and increased left atrial diameter compared with controls (3.75 ± 0.42; 3.61 ± 0.41, p = 0.001), respectively. These associated characteristics correspond to a 16.6 increase in the likelihood of OSA regardless of reporting any symptoms of this disorder, such as sleepiness or snoring. CONCLUSION: In the sample studied, the mostly found cardiovascular profile of patients with OSA was: obesity, hypertension, low plasma levels of HDL and left atrial diameter increased.