Estrogen and Its Receptors in Efferent Ductules and Epididymis
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.2164/jandrol.110.012872 http://repositorio.unifesp.br/handle/11600/34172 |
Resumo: | Estrogens play key roles in the development and maintenance of male reproductive function and fertility. in this review, we briefly describe the localization and function of estrogen receptors ESR1 and ESR2 (also known as ER alpha and ER beta, respectively) and the expression of G protein-coupled estrogen receptor-1 (GPER, formerly known as GPR30) in efferent ductules and epididymis. the efferent ductules present the highest levels of ESR1 and ESR2 in the male reproductive system, and represent a major target of estrogen action. in efferent ductules, ESR1 has a crucial role in the regulation of fluid reabsorption, and in the epididymis the receptor helps to maintain fluid osmolality and pH. ESR1 expression in the epididymal epithelium shows considerable variation among species, but differences in laboratory techniques may also contribute to this variation. Here we report that Esr1 mRNA and protein are higher in corpus than in other regions of the rat epididymis. the mRNA level for Gper was also higher in corpus. Although ESR1 is expressed constitutively in efferent ductules and down-regulated by estrogen, in the epididymis, both testosterone (T) and estradiol (E2) may regulate its expression. T and E2 are, respectively, higher and lower in the corpus than in the initial segment/caput and cauda regions. It is important to determine the expression of GPER, ESR1, androgen receptor, and their respective cofactors in specific cell types of this tissue, as well as the intracellular signaling pathways involved in efferent ductules and epididymis. These studies will help to explain the consequences of exposures to environmental endocrine disruptors and provide potential targets for the development of a male contraceptive. |
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Estrogen and Its Receptors in Efferent Ductules and EpididymisEstrogen receptorsGperEstrogens play key roles in the development and maintenance of male reproductive function and fertility. in this review, we briefly describe the localization and function of estrogen receptors ESR1 and ESR2 (also known as ER alpha and ER beta, respectively) and the expression of G protein-coupled estrogen receptor-1 (GPER, formerly known as GPR30) in efferent ductules and epididymis. the efferent ductules present the highest levels of ESR1 and ESR2 in the male reproductive system, and represent a major target of estrogen action. in efferent ductules, ESR1 has a crucial role in the regulation of fluid reabsorption, and in the epididymis the receptor helps to maintain fluid osmolality and pH. ESR1 expression in the epididymal epithelium shows considerable variation among species, but differences in laboratory techniques may also contribute to this variation. Here we report that Esr1 mRNA and protein are higher in corpus than in other regions of the rat epididymis. the mRNA level for Gper was also higher in corpus. Although ESR1 is expressed constitutively in efferent ductules and down-regulated by estrogen, in the epididymis, both testosterone (T) and estradiol (E2) may regulate its expression. T and E2 are, respectively, higher and lower in the corpus than in the initial segment/caput and cauda regions. It is important to determine the expression of GPER, ESR1, androgen receptor, and their respective cofactors in specific cell types of this tissue, as well as the intracellular signaling pathways involved in efferent ductules and epididymis. These studies will help to explain the consequences of exposures to environmental endocrine disruptors and provide potential targets for the development of a male contraceptive.Univ Illinois, Dept Comparat Biosci, Urbana, IL 61802 USAUniversidade Federal de São Paulo, Sect Expt Endocrinol, Dept Pharmacol, Escola Paulista Med, São Paulo, BrazilUniv Fed Minas Gerais, Dept Morphol, Belo Horizonte, MG, BrazilUniversidade Federal de São Paulo, Sect Expt Endocrinol, Dept Pharmacol, Escola Paulista Med, São Paulo, BrazilWeb of ScienceAmer Soc Andrology, IncUniv IllinoisUniversidade Federal de São Paulo (UNIFESP)Universidade Federal de Minas Gerais (UFMG)Hess, Rex A.Fernandes, Sheilla Alessandra Ferreira [UNIFESP]Gomes, Gisele Renata de Oliveira [UNIFESP]Oliveira, Cleida A.Lazari, Maria de Fatima Magalhaes [UNIFESP]Porto, Catarina Segreti [UNIFESP]2016-01-24T14:17:21Z2016-01-24T14:17:21Z2011-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion600-613http://dx.doi.org/10.2164/jandrol.110.012872Journal of Andrology. Lawrence: Amer Soc Andrology, Inc, v. 32, n. 6, p. 600-613, 2011.10.2164/jandrol.110.0128720196-3635http://repositorio.unifesp.br/handle/11600/34172WOS:000296037400007engJournal of Andrologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2022-02-18T12:08:06Zoai:repositorio.unifesp.br/:11600/34172Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652022-02-18T12:08:06Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Estrogen and Its Receptors in Efferent Ductules and Epididymis |
title |
Estrogen and Its Receptors in Efferent Ductules and Epididymis |
spellingShingle |
Estrogen and Its Receptors in Efferent Ductules and Epididymis Hess, Rex A. Estrogen receptors Gper |
title_short |
Estrogen and Its Receptors in Efferent Ductules and Epididymis |
title_full |
Estrogen and Its Receptors in Efferent Ductules and Epididymis |
title_fullStr |
Estrogen and Its Receptors in Efferent Ductules and Epididymis |
title_full_unstemmed |
Estrogen and Its Receptors in Efferent Ductules and Epididymis |
title_sort |
Estrogen and Its Receptors in Efferent Ductules and Epididymis |
author |
Hess, Rex A. |
author_facet |
Hess, Rex A. Fernandes, Sheilla Alessandra Ferreira [UNIFESP] Gomes, Gisele Renata de Oliveira [UNIFESP] Oliveira, Cleida A. Lazari, Maria de Fatima Magalhaes [UNIFESP] Porto, Catarina Segreti [UNIFESP] |
author_role |
author |
author2 |
Fernandes, Sheilla Alessandra Ferreira [UNIFESP] Gomes, Gisele Renata de Oliveira [UNIFESP] Oliveira, Cleida A. Lazari, Maria de Fatima Magalhaes [UNIFESP] Porto, Catarina Segreti [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Univ Illinois Universidade Federal de São Paulo (UNIFESP) Universidade Federal de Minas Gerais (UFMG) |
dc.contributor.author.fl_str_mv |
Hess, Rex A. Fernandes, Sheilla Alessandra Ferreira [UNIFESP] Gomes, Gisele Renata de Oliveira [UNIFESP] Oliveira, Cleida A. Lazari, Maria de Fatima Magalhaes [UNIFESP] Porto, Catarina Segreti [UNIFESP] |
dc.subject.por.fl_str_mv |
Estrogen receptors Gper |
topic |
Estrogen receptors Gper |
description |
Estrogens play key roles in the development and maintenance of male reproductive function and fertility. in this review, we briefly describe the localization and function of estrogen receptors ESR1 and ESR2 (also known as ER alpha and ER beta, respectively) and the expression of G protein-coupled estrogen receptor-1 (GPER, formerly known as GPR30) in efferent ductules and epididymis. the efferent ductules present the highest levels of ESR1 and ESR2 in the male reproductive system, and represent a major target of estrogen action. in efferent ductules, ESR1 has a crucial role in the regulation of fluid reabsorption, and in the epididymis the receptor helps to maintain fluid osmolality and pH. ESR1 expression in the epididymal epithelium shows considerable variation among species, but differences in laboratory techniques may also contribute to this variation. Here we report that Esr1 mRNA and protein are higher in corpus than in other regions of the rat epididymis. the mRNA level for Gper was also higher in corpus. Although ESR1 is expressed constitutively in efferent ductules and down-regulated by estrogen, in the epididymis, both testosterone (T) and estradiol (E2) may regulate its expression. T and E2 are, respectively, higher and lower in the corpus than in the initial segment/caput and cauda regions. It is important to determine the expression of GPER, ESR1, androgen receptor, and their respective cofactors in specific cell types of this tissue, as well as the intracellular signaling pathways involved in efferent ductules and epididymis. These studies will help to explain the consequences of exposures to environmental endocrine disruptors and provide potential targets for the development of a male contraceptive. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-11-01 2016-01-24T14:17:21Z 2016-01-24T14:17:21Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.2164/jandrol.110.012872 Journal of Andrology. Lawrence: Amer Soc Andrology, Inc, v. 32, n. 6, p. 600-613, 2011. 10.2164/jandrol.110.012872 0196-3635 http://repositorio.unifesp.br/handle/11600/34172 WOS:000296037400007 |
url |
http://dx.doi.org/10.2164/jandrol.110.012872 http://repositorio.unifesp.br/handle/11600/34172 |
identifier_str_mv |
Journal of Andrology. Lawrence: Amer Soc Andrology, Inc, v. 32, n. 6, p. 600-613, 2011. 10.2164/jandrol.110.012872 0196-3635 WOS:000296037400007 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Andrology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
600-613 |
dc.publisher.none.fl_str_mv |
Amer Soc Andrology, Inc |
publisher.none.fl_str_mv |
Amer Soc Andrology, Inc |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268271756574720 |