Estrogen and Its Receptors in Efferent Ductules and Epididymis

Detalhes bibliográficos
Autor(a) principal: Hess, Rex A.
Data de Publicação: 2011
Outros Autores: Fernandes, Sheilla Alessandra Ferreira [UNIFESP], Gomes, Gisele Renata de Oliveira [UNIFESP], Oliveira, Cleida A., Lazari, Maria de Fatima Magalhaes [UNIFESP], Porto, Catarina Segreti [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.2164/jandrol.110.012872
http://repositorio.unifesp.br/handle/11600/34172
Resumo: Estrogens play key roles in the development and maintenance of male reproductive function and fertility. in this review, we briefly describe the localization and function of estrogen receptors ESR1 and ESR2 (also known as ER alpha and ER beta, respectively) and the expression of G protein-coupled estrogen receptor-1 (GPER, formerly known as GPR30) in efferent ductules and epididymis. the efferent ductules present the highest levels of ESR1 and ESR2 in the male reproductive system, and represent a major target of estrogen action. in efferent ductules, ESR1 has a crucial role in the regulation of fluid reabsorption, and in the epididymis the receptor helps to maintain fluid osmolality and pH. ESR1 expression in the epididymal epithelium shows considerable variation among species, but differences in laboratory techniques may also contribute to this variation. Here we report that Esr1 mRNA and protein are higher in corpus than in other regions of the rat epididymis. the mRNA level for Gper was also higher in corpus. Although ESR1 is expressed constitutively in efferent ductules and down-regulated by estrogen, in the epididymis, both testosterone (T) and estradiol (E2) may regulate its expression. T and E2 are, respectively, higher and lower in the corpus than in the initial segment/caput and cauda regions. It is important to determine the expression of GPER, ESR1, androgen receptor, and their respective cofactors in specific cell types of this tissue, as well as the intracellular signaling pathways involved in efferent ductules and epididymis. These studies will help to explain the consequences of exposures to environmental endocrine disruptors and provide potential targets for the development of a male contraceptive.
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spelling Estrogen and Its Receptors in Efferent Ductules and EpididymisEstrogen receptorsGperEstrogens play key roles in the development and maintenance of male reproductive function and fertility. in this review, we briefly describe the localization and function of estrogen receptors ESR1 and ESR2 (also known as ER alpha and ER beta, respectively) and the expression of G protein-coupled estrogen receptor-1 (GPER, formerly known as GPR30) in efferent ductules and epididymis. the efferent ductules present the highest levels of ESR1 and ESR2 in the male reproductive system, and represent a major target of estrogen action. in efferent ductules, ESR1 has a crucial role in the regulation of fluid reabsorption, and in the epididymis the receptor helps to maintain fluid osmolality and pH. ESR1 expression in the epididymal epithelium shows considerable variation among species, but differences in laboratory techniques may also contribute to this variation. Here we report that Esr1 mRNA and protein are higher in corpus than in other regions of the rat epididymis. the mRNA level for Gper was also higher in corpus. Although ESR1 is expressed constitutively in efferent ductules and down-regulated by estrogen, in the epididymis, both testosterone (T) and estradiol (E2) may regulate its expression. T and E2 are, respectively, higher and lower in the corpus than in the initial segment/caput and cauda regions. It is important to determine the expression of GPER, ESR1, androgen receptor, and their respective cofactors in specific cell types of this tissue, as well as the intracellular signaling pathways involved in efferent ductules and epididymis. These studies will help to explain the consequences of exposures to environmental endocrine disruptors and provide potential targets for the development of a male contraceptive.Univ Illinois, Dept Comparat Biosci, Urbana, IL 61802 USAUniversidade Federal de São Paulo, Sect Expt Endocrinol, Dept Pharmacol, Escola Paulista Med, São Paulo, BrazilUniv Fed Minas Gerais, Dept Morphol, Belo Horizonte, MG, BrazilUniversidade Federal de São Paulo, Sect Expt Endocrinol, Dept Pharmacol, Escola Paulista Med, São Paulo, BrazilWeb of ScienceAmer Soc Andrology, IncUniv IllinoisUniversidade Federal de São Paulo (UNIFESP)Universidade Federal de Minas Gerais (UFMG)Hess, Rex A.Fernandes, Sheilla Alessandra Ferreira [UNIFESP]Gomes, Gisele Renata de Oliveira [UNIFESP]Oliveira, Cleida A.Lazari, Maria de Fatima Magalhaes [UNIFESP]Porto, Catarina Segreti [UNIFESP]2016-01-24T14:17:21Z2016-01-24T14:17:21Z2011-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion600-613http://dx.doi.org/10.2164/jandrol.110.012872Journal of Andrology. Lawrence: Amer Soc Andrology, Inc, v. 32, n. 6, p. 600-613, 2011.10.2164/jandrol.110.0128720196-3635http://repositorio.unifesp.br/handle/11600/34172WOS:000296037400007engJournal of Andrologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2022-02-18T12:08:06Zoai:repositorio.unifesp.br/:11600/34172Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652022-02-18T12:08:06Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Estrogen and Its Receptors in Efferent Ductules and Epididymis
title Estrogen and Its Receptors in Efferent Ductules and Epididymis
spellingShingle Estrogen and Its Receptors in Efferent Ductules and Epididymis
Hess, Rex A.
Estrogen receptors
Gper
title_short Estrogen and Its Receptors in Efferent Ductules and Epididymis
title_full Estrogen and Its Receptors in Efferent Ductules and Epididymis
title_fullStr Estrogen and Its Receptors in Efferent Ductules and Epididymis
title_full_unstemmed Estrogen and Its Receptors in Efferent Ductules and Epididymis
title_sort Estrogen and Its Receptors in Efferent Ductules and Epididymis
author Hess, Rex A.
author_facet Hess, Rex A.
Fernandes, Sheilla Alessandra Ferreira [UNIFESP]
Gomes, Gisele Renata de Oliveira [UNIFESP]
Oliveira, Cleida A.
Lazari, Maria de Fatima Magalhaes [UNIFESP]
Porto, Catarina Segreti [UNIFESP]
author_role author
author2 Fernandes, Sheilla Alessandra Ferreira [UNIFESP]
Gomes, Gisele Renata de Oliveira [UNIFESP]
Oliveira, Cleida A.
Lazari, Maria de Fatima Magalhaes [UNIFESP]
Porto, Catarina Segreti [UNIFESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Univ Illinois
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Minas Gerais (UFMG)
dc.contributor.author.fl_str_mv Hess, Rex A.
Fernandes, Sheilla Alessandra Ferreira [UNIFESP]
Gomes, Gisele Renata de Oliveira [UNIFESP]
Oliveira, Cleida A.
Lazari, Maria de Fatima Magalhaes [UNIFESP]
Porto, Catarina Segreti [UNIFESP]
dc.subject.por.fl_str_mv Estrogen receptors
Gper
topic Estrogen receptors
Gper
description Estrogens play key roles in the development and maintenance of male reproductive function and fertility. in this review, we briefly describe the localization and function of estrogen receptors ESR1 and ESR2 (also known as ER alpha and ER beta, respectively) and the expression of G protein-coupled estrogen receptor-1 (GPER, formerly known as GPR30) in efferent ductules and epididymis. the efferent ductules present the highest levels of ESR1 and ESR2 in the male reproductive system, and represent a major target of estrogen action. in efferent ductules, ESR1 has a crucial role in the regulation of fluid reabsorption, and in the epididymis the receptor helps to maintain fluid osmolality and pH. ESR1 expression in the epididymal epithelium shows considerable variation among species, but differences in laboratory techniques may also contribute to this variation. Here we report that Esr1 mRNA and protein are higher in corpus than in other regions of the rat epididymis. the mRNA level for Gper was also higher in corpus. Although ESR1 is expressed constitutively in efferent ductules and down-regulated by estrogen, in the epididymis, both testosterone (T) and estradiol (E2) may regulate its expression. T and E2 are, respectively, higher and lower in the corpus than in the initial segment/caput and cauda regions. It is important to determine the expression of GPER, ESR1, androgen receptor, and their respective cofactors in specific cell types of this tissue, as well as the intracellular signaling pathways involved in efferent ductules and epididymis. These studies will help to explain the consequences of exposures to environmental endocrine disruptors and provide potential targets for the development of a male contraceptive.
publishDate 2011
dc.date.none.fl_str_mv 2011-11-01
2016-01-24T14:17:21Z
2016-01-24T14:17:21Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.2164/jandrol.110.012872
Journal of Andrology. Lawrence: Amer Soc Andrology, Inc, v. 32, n. 6, p. 600-613, 2011.
10.2164/jandrol.110.012872
0196-3635
http://repositorio.unifesp.br/handle/11600/34172
WOS:000296037400007
url http://dx.doi.org/10.2164/jandrol.110.012872
http://repositorio.unifesp.br/handle/11600/34172
identifier_str_mv Journal of Andrology. Lawrence: Amer Soc Andrology, Inc, v. 32, n. 6, p. 600-613, 2011.
10.2164/jandrol.110.012872
0196-3635
WOS:000296037400007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Andrology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 600-613
dc.publisher.none.fl_str_mv Amer Soc Andrology, Inc
publisher.none.fl_str_mv Amer Soc Andrology, Inc
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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