Efeitos da exposição à fumaça lateral do cigarro sobre o barorreflexo em ratos adultos

• Autor(a) principal: Valenti, Vitor Engrácia [UNIFESP]
• Data de Publicação: 2011
• Outros Autores: Abreu, Luiz Carlos de, Ferreira, Celso [UNIFESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S0066-782X2010005000164; http://repositorio.unifesp.br/handle/11600/6316
• topic: Tobacco; smoke; smoke inhalation injury; baroreflex; rats; Tabaco; fumaça; lesão por inalação de fumaça; barorreflexo; ratos

BACKGROUND: It has been evidenced in the literature that exposure to cigarette smoke causes hypertension in rats; however, it has not been demonstrated if the baroreflex function is impaired before the animal becomes hypertensive. OBJECTIVE: We evaluated short-term effects of sidestream cigarette smoke (SSCS) exposure on baroreflex function in Wistar normotensive rats. METHODS: Rats were exposed to SSCS during three weeks, 180 minutes, five days per week, at a concentration of monoxide carbon between 100-300 ppm. Mean arterial pressure (MAP) and heart rate (HR) were evaluated through cannulation of the femoral vein and artery. RESULTS: There was no significant difference between control and SSCS groups regarding basal mean arterial pressure and heart rate, sympathetic and parasympathetic components of the baroreflex function. CONCLUSION: Our data suggest that three weeks of exposure to SSCS is not enough to significantly impair cardiovascular parameters and baroreflex sensitivity in normotensive Wistar rats.