Treatment of patients with uric acid stones

Detalhes bibliográficos
Autor(a) principal: Heilberg, Ita Pfeferman [UNIFESP]
Data de Publicação: 2016
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: https://repositorio.unifesp.br/handle/11600/58516
https://doi.org/10.1007/s00240-015-0843-8
Resumo: Uric acid nephrolithiasis and unduly acidic urinary pH are both considered a renal manifestation of insulin resistance but the underlying mechanisms for the development of low urinary pH and the propensity for uric acid stone formation are not completely elucidated. Nevertheless, excessive dietary acid intake, increased endogenous acid production and/or defective NH4+ excretion play an important role, among other factors. The main principles of therapy for uric acid nephrolithiasis are aimed at urinary alkalinization through diet modification or pharmacologic agents, increase of urinary volume, and less importantly at the reduction of uric acid excretion.
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spelling Heilberg, Ita Pfeferman [UNIFESP]2020-10-30T18:46:34Z2020-10-30T18:46:34Z2016Urolithiasis. New York, v. 44, n. 1, p. 57-63, 2016.2194-7228https://repositorio.unifesp.br/handle/11600/58516https://doi.org/10.1007/s00240-015-0843-810.1007/s00240-015-0843-8WOS:000368811600008Uric acid nephrolithiasis and unduly acidic urinary pH are both considered a renal manifestation of insulin resistance but the underlying mechanisms for the development of low urinary pH and the propensity for uric acid stone formation are not completely elucidated. Nevertheless, excessive dietary acid intake, increased endogenous acid production and/or defective NH4+ excretion play an important role, among other factors. The main principles of therapy for uric acid nephrolithiasis are aimed at urinary alkalinization through diet modification or pharmacologic agents, increase of urinary volume, and less importantly at the reduction of uric acid excretion.Conselho Nacional de Pesquisa e Desenvolvimento (CNPq)Fed Univ Sao Paulo UNIFESP, Div Nephrol, Rua Botucatu 740, BR-04023900 Sao Paulo, SP, BrazilFed Univ Sao Paulo UNIFESP, Div Nephrol, Rua Botucatu 740, BR-04023900 Sao Paulo, SP, BrazilCNPq: 305638/2012-2Web of Science57-63engSpringerUrolithiasisUric acidStonesNephrolithiasisUrateAcidic pHTreatment of patients with uric acid stonesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNew York441info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/585162022-02-08 17:50:49.168metadata only accessoai:repositorio.unifesp.br:11600/58516Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-02-08T20:50:49Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.en.fl_str_mv Treatment of patients with uric acid stones
title Treatment of patients with uric acid stones
spellingShingle Treatment of patients with uric acid stones
Heilberg, Ita Pfeferman [UNIFESP]
Uric acid
Stones
Nephrolithiasis
Urate
Acidic pH
title_short Treatment of patients with uric acid stones
title_full Treatment of patients with uric acid stones
title_fullStr Treatment of patients with uric acid stones
title_full_unstemmed Treatment of patients with uric acid stones
title_sort Treatment of patients with uric acid stones
author Heilberg, Ita Pfeferman [UNIFESP]
author_facet Heilberg, Ita Pfeferman [UNIFESP]
author_role author
dc.contributor.author.fl_str_mv Heilberg, Ita Pfeferman [UNIFESP]
dc.subject.eng.fl_str_mv Uric acid
Stones
Nephrolithiasis
Urate
Acidic pH
topic Uric acid
Stones
Nephrolithiasis
Urate
Acidic pH
description Uric acid nephrolithiasis and unduly acidic urinary pH are both considered a renal manifestation of insulin resistance but the underlying mechanisms for the development of low urinary pH and the propensity for uric acid stone formation are not completely elucidated. Nevertheless, excessive dietary acid intake, increased endogenous acid production and/or defective NH4+ excretion play an important role, among other factors. The main principles of therapy for uric acid nephrolithiasis are aimed at urinary alkalinization through diet modification or pharmacologic agents, increase of urinary volume, and less importantly at the reduction of uric acid excretion.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2020-10-30T18:46:34Z
dc.date.available.fl_str_mv 2020-10-30T18:46:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Urolithiasis. New York, v. 44, n. 1, p. 57-63, 2016.
dc.identifier.uri.fl_str_mv https://repositorio.unifesp.br/handle/11600/58516
https://doi.org/10.1007/s00240-015-0843-8
dc.identifier.issn.none.fl_str_mv 2194-7228
dc.identifier.doi.none.fl_str_mv 10.1007/s00240-015-0843-8
dc.identifier.wos.none.fl_str_mv WOS:000368811600008
identifier_str_mv Urolithiasis. New York, v. 44, n. 1, p. 57-63, 2016.
2194-7228
10.1007/s00240-015-0843-8
WOS:000368811600008
url https://repositorio.unifesp.br/handle/11600/58516
https://doi.org/10.1007/s00240-015-0843-8
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Urolithiasis
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 57-63
dc.coverage.none.fl_str_mv New York
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv
_version_ 1802764119466573824

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