Treatment of patients with uric acid stones
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/58516 https://doi.org/10.1007/s00240-015-0843-8 |
Resumo: | Uric acid nephrolithiasis and unduly acidic urinary pH are both considered a renal manifestation of insulin resistance but the underlying mechanisms for the development of low urinary pH and the propensity for uric acid stone formation are not completely elucidated. Nevertheless, excessive dietary acid intake, increased endogenous acid production and/or defective NH4+ excretion play an important role, among other factors. The main principles of therapy for uric acid nephrolithiasis are aimed at urinary alkalinization through diet modification or pharmacologic agents, increase of urinary volume, and less importantly at the reduction of uric acid excretion. |
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Heilberg, Ita Pfeferman [UNIFESP]2020-10-30T18:46:34Z2020-10-30T18:46:34Z2016Urolithiasis. New York, v. 44, n. 1, p. 57-63, 2016.2194-7228https://repositorio.unifesp.br/handle/11600/58516https://doi.org/10.1007/s00240-015-0843-810.1007/s00240-015-0843-8WOS:000368811600008Uric acid nephrolithiasis and unduly acidic urinary pH are both considered a renal manifestation of insulin resistance but the underlying mechanisms for the development of low urinary pH and the propensity for uric acid stone formation are not completely elucidated. Nevertheless, excessive dietary acid intake, increased endogenous acid production and/or defective NH4+ excretion play an important role, among other factors. The main principles of therapy for uric acid nephrolithiasis are aimed at urinary alkalinization through diet modification or pharmacologic agents, increase of urinary volume, and less importantly at the reduction of uric acid excretion.Conselho Nacional de Pesquisa e Desenvolvimento (CNPq)Fed Univ Sao Paulo UNIFESP, Div Nephrol, Rua Botucatu 740, BR-04023900 Sao Paulo, SP, BrazilFed Univ Sao Paulo UNIFESP, Div Nephrol, Rua Botucatu 740, BR-04023900 Sao Paulo, SP, BrazilCNPq: 305638/2012-2Web of Science57-63engSpringerUrolithiasisUric acidStonesNephrolithiasisUrateAcidic pHTreatment of patients with uric acid stonesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNew York441info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/585162022-02-08 17:50:49.168metadata only accessoai:repositorio.unifesp.br:11600/58516Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-02-08T20:50:49Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Treatment of patients with uric acid stones |
title |
Treatment of patients with uric acid stones |
spellingShingle |
Treatment of patients with uric acid stones Heilberg, Ita Pfeferman [UNIFESP] Uric acid Stones Nephrolithiasis Urate Acidic pH |
title_short |
Treatment of patients with uric acid stones |
title_full |
Treatment of patients with uric acid stones |
title_fullStr |
Treatment of patients with uric acid stones |
title_full_unstemmed |
Treatment of patients with uric acid stones |
title_sort |
Treatment of patients with uric acid stones |
author |
Heilberg, Ita Pfeferman [UNIFESP] |
author_facet |
Heilberg, Ita Pfeferman [UNIFESP] |
author_role |
author |
dc.contributor.author.fl_str_mv |
Heilberg, Ita Pfeferman [UNIFESP] |
dc.subject.eng.fl_str_mv |
Uric acid Stones Nephrolithiasis Urate Acidic pH |
topic |
Uric acid Stones Nephrolithiasis Urate Acidic pH |
description |
Uric acid nephrolithiasis and unduly acidic urinary pH are both considered a renal manifestation of insulin resistance but the underlying mechanisms for the development of low urinary pH and the propensity for uric acid stone formation are not completely elucidated. Nevertheless, excessive dietary acid intake, increased endogenous acid production and/or defective NH4+ excretion play an important role, among other factors. The main principles of therapy for uric acid nephrolithiasis are aimed at urinary alkalinization through diet modification or pharmacologic agents, increase of urinary volume, and less importantly at the reduction of uric acid excretion. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2020-10-30T18:46:34Z |
dc.date.available.fl_str_mv |
2020-10-30T18:46:34Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Urolithiasis. New York, v. 44, n. 1, p. 57-63, 2016. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/58516 https://doi.org/10.1007/s00240-015-0843-8 |
dc.identifier.issn.none.fl_str_mv |
2194-7228 |
dc.identifier.doi.none.fl_str_mv |
10.1007/s00240-015-0843-8 |
dc.identifier.wos.none.fl_str_mv |
WOS:000368811600008 |
identifier_str_mv |
Urolithiasis. New York, v. 44, n. 1, p. 57-63, 2016. 2194-7228 10.1007/s00240-015-0843-8 WOS:000368811600008 |
url |
https://repositorio.unifesp.br/handle/11600/58516 https://doi.org/10.1007/s00240-015-0843-8 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Urolithiasis |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
57-63 |
dc.coverage.none.fl_str_mv |
New York |
dc.publisher.none.fl_str_mv |
Springer |
publisher.none.fl_str_mv |
Springer |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
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1802764119466573824 |