cagA positive Helicobacter pylori in Brazilian children related to chronic gastritis
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/S1413-86702006000400008 http://repositorio.unifesp.br/handle/11600/3174 |
Resumo: | Helicobacter pylori is a spiral-shaped Gram-negative bacterium. It colonizes the gastric mucosa of humans and persists for decades if not treated. Helicobacter pylori infection affects more than half of the world's population and invariably results in chronic gastritis. The cagA gene is present in about 60 to 70% of H. pylori strains; it encodes a high-molecular-weight protein (120 to 140 kDa) and several investigators have noted a correlation between strains that possess cagA and the severity of gastric mucosal inflammation. We examined the relation between cagA status in H. pylori strains and chronic gastritis with inflammatory processes in children from Marília, São Paulo, Brazil. One-hundred-twenty-one children were analyzed histopathologically and by polymerase chain reaction (PCR) to detect H. pylori and cagA. We then looked for an association between cagA presence and inflammatory infiltration. Using histology and PCR, we found 47% H. pylori positive infection; 29 children were diagnosed with chronic gastritis, while 28 showed normal mucosa by histopathological analysis. CagA presence was genotyped in both groups, and an inflammatory infiltrate was studied in all infected children with chronic gastritis. We found cagA strains in 20 of 29 (69%) children with chronic gastritis and 18 of 28 (64%) with normal mucosa, demonstrating a strong relationship between the strains and the inflammatory process. We found a positive association between an inflammatory process associated with H. pylori of cagA+ strains and chronic gastritis development. |
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cagA positive Helicobacter pylori in Brazilian children related to chronic gastritisHelicobacter pylori infectioncagAinflammatory infiltrateHelicobacter pylori is a spiral-shaped Gram-negative bacterium. It colonizes the gastric mucosa of humans and persists for decades if not treated. Helicobacter pylori infection affects more than half of the world's population and invariably results in chronic gastritis. The cagA gene is present in about 60 to 70% of H. pylori strains; it encodes a high-molecular-weight protein (120 to 140 kDa) and several investigators have noted a correlation between strains that possess cagA and the severity of gastric mucosal inflammation. We examined the relation between cagA status in H. pylori strains and chronic gastritis with inflammatory processes in children from Marília, São Paulo, Brazil. One-hundred-twenty-one children were analyzed histopathologically and by polymerase chain reaction (PCR) to detect H. pylori and cagA. We then looked for an association between cagA presence and inflammatory infiltration. Using histology and PCR, we found 47% H. pylori positive infection; 29 children were diagnosed with chronic gastritis, while 28 showed normal mucosa by histopathological analysis. CagA presence was genotyped in both groups, and an inflammatory infiltrate was studied in all infected children with chronic gastritis. We found cagA strains in 20 of 29 (69%) children with chronic gastritis and 18 of 28 (64%) with normal mucosa, demonstrating a strong relationship between the strains and the inflammatory process. We found a positive association between an inflammatory process associated with H. pylori of cagA+ strains and chronic gastritis development.School of Medicine of Marília Department of Genetic and Molecular Biology HemocentroUNIFESP-EPM Department of GeneticFAMEMA Department of PathologyUNIFESP, EPM, Department of GeneticSciELOFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Brazilian Society of Infectious DiseasesSchool of Medicine of Marília Department of Genetic and Molecular Biology HemocentroUniversidade Federal de São Paulo (UNIFESP)FAMEMA Department of PathologyGatti, Luciano Lobo [UNIFESP]Lábio, Roger Willian deSilva, Luiz Carlos daSmith, Marilia de Arruda Cardoso [UNIFESP]Payão, Spencer Luiz Marques [UNIFESP]2015-06-14T13:36:21Z2015-06-14T13:36:21Z2006-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion254-258application/pdfhttp://dx.doi.org/10.1590/S1413-86702006000400008Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 10, n. 4, p. 254-258, 2006.10.1590/S1413-86702006000400008S1413-86702006000400008.pdf1413-8670S1413-86702006000400008http://repositorio.unifesp.br/handle/11600/3174engBrazilian Journal of Infectious Diseasesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-06T05:24:05Zoai:repositorio.unifesp.br/:11600/3174Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-06T05:24:05Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
cagA positive Helicobacter pylori in Brazilian children related to chronic gastritis |
title |
cagA positive Helicobacter pylori in Brazilian children related to chronic gastritis |
spellingShingle |
cagA positive Helicobacter pylori in Brazilian children related to chronic gastritis Gatti, Luciano Lobo [UNIFESP] Helicobacter pylori infection cagA inflammatory infiltrate |
title_short |
cagA positive Helicobacter pylori in Brazilian children related to chronic gastritis |
title_full |
cagA positive Helicobacter pylori in Brazilian children related to chronic gastritis |
title_fullStr |
cagA positive Helicobacter pylori in Brazilian children related to chronic gastritis |
title_full_unstemmed |
cagA positive Helicobacter pylori in Brazilian children related to chronic gastritis |
title_sort |
cagA positive Helicobacter pylori in Brazilian children related to chronic gastritis |
author |
Gatti, Luciano Lobo [UNIFESP] |
author_facet |
Gatti, Luciano Lobo [UNIFESP] Lábio, Roger Willian de Silva, Luiz Carlos da Smith, Marilia de Arruda Cardoso [UNIFESP] Payão, Spencer Luiz Marques [UNIFESP] |
author_role |
author |
author2 |
Lábio, Roger Willian de Silva, Luiz Carlos da Smith, Marilia de Arruda Cardoso [UNIFESP] Payão, Spencer Luiz Marques [UNIFESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
School of Medicine of Marília Department of Genetic and Molecular Biology Hemocentro Universidade Federal de São Paulo (UNIFESP) FAMEMA Department of Pathology |
dc.contributor.author.fl_str_mv |
Gatti, Luciano Lobo [UNIFESP] Lábio, Roger Willian de Silva, Luiz Carlos da Smith, Marilia de Arruda Cardoso [UNIFESP] Payão, Spencer Luiz Marques [UNIFESP] |
dc.subject.por.fl_str_mv |
Helicobacter pylori infection cagA inflammatory infiltrate |
topic |
Helicobacter pylori infection cagA inflammatory infiltrate |
description |
Helicobacter pylori is a spiral-shaped Gram-negative bacterium. It colonizes the gastric mucosa of humans and persists for decades if not treated. Helicobacter pylori infection affects more than half of the world's population and invariably results in chronic gastritis. The cagA gene is present in about 60 to 70% of H. pylori strains; it encodes a high-molecular-weight protein (120 to 140 kDa) and several investigators have noted a correlation between strains that possess cagA and the severity of gastric mucosal inflammation. We examined the relation between cagA status in H. pylori strains and chronic gastritis with inflammatory processes in children from Marília, São Paulo, Brazil. One-hundred-twenty-one children were analyzed histopathologically and by polymerase chain reaction (PCR) to detect H. pylori and cagA. We then looked for an association between cagA presence and inflammatory infiltration. Using histology and PCR, we found 47% H. pylori positive infection; 29 children were diagnosed with chronic gastritis, while 28 showed normal mucosa by histopathological analysis. CagA presence was genotyped in both groups, and an inflammatory infiltrate was studied in all infected children with chronic gastritis. We found cagA strains in 20 of 29 (69%) children with chronic gastritis and 18 of 28 (64%) with normal mucosa, demonstrating a strong relationship between the strains and the inflammatory process. We found a positive association between an inflammatory process associated with H. pylori of cagA+ strains and chronic gastritis development. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-08-01 2015-06-14T13:36:21Z 2015-06-14T13:36:21Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1413-86702006000400008 Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 10, n. 4, p. 254-258, 2006. 10.1590/S1413-86702006000400008 S1413-86702006000400008.pdf 1413-8670 S1413-86702006000400008 http://repositorio.unifesp.br/handle/11600/3174 |
url |
http://dx.doi.org/10.1590/S1413-86702006000400008 http://repositorio.unifesp.br/handle/11600/3174 |
identifier_str_mv |
Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 10, n. 4, p. 254-258, 2006. 10.1590/S1413-86702006000400008 S1413-86702006000400008.pdf 1413-8670 S1413-86702006000400008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Infectious Diseases |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
254-258 application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268274164105216 |