The consequence of genetic polymorphisms of cagA and vacA virulence factors on gastroduodenal disorders affected by Helicobacter pylori

Detalhes bibliográficos
Autor(a) principal: Santana, Cleiton Moreira
Data de Publicação: 2021
Outros Autores: Santos, Raíssa Lima, Palma, Tarciso de Figueiredo, Oliveira, Ana Carolina Santana de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/12938
Resumo: The virulence factors cagA and vacA, are closely related to the pathogenicity of Helicobacter pylori. These factors are widely studied and associated with a higher risk of developing several gastroduodenal clinical outcomes, such as gastric cancer. Besides presenting several genetic polymorphisms, which can vary according to the geographic region, leading to different levels of toxicity and clinical gastric manifestations. Through an integrative review of the literature we analyzed the clinical/epidemiological studies published between 2015 and 2020 in the LILACS, Scielo and PubMed databases, aiming to gather the most recent and important data on the various polymorphisms in the factors of virulence cagA and vacA and gastroduodenal clinical outcomes. Nineteen studies were identified that contemplated the objective of this review and a great variety of polymorphisms and genetic combinations of these virulence factors were observed in association with several clinical outcomes. It was also noted the existence of genetic profiles of prevalence of H. pylori strains and associations with distinct gastric pathologies in certain geographical regions. Although some conflicting results were identified, the understanding of these findings and the identification of possible contributing genes in gastric pathologies may serve as markers for the development of strategies for the prevention of these pathologies and better treatment efficacy.
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spelling The consequence of genetic polymorphisms of cagA and vacA virulence factors on gastroduodenal disorders affected by Helicobacter pyloriLa consecuencia de los polimorfismos genéticos de los factores de virulencia cagA y vacA en los trastornos gastroduodenales afectados por el Helicobacter pyloriA consequência dos polimorfismos genéticos dos fatores de virulência cagA e vacA nas desordens gastroduodenais acometidas por Helicobacter pyloriHelicobacter pyloriFactores de virulênciaCagAVacAGastropatías.Helicobacter pyloriVirulence factorsCagAVacAGastropathies.Helicobacter pyloriCagAVacAGastropatias.The virulence factors cagA and vacA, are closely related to the pathogenicity of Helicobacter pylori. These factors are widely studied and associated with a higher risk of developing several gastroduodenal clinical outcomes, such as gastric cancer. Besides presenting several genetic polymorphisms, which can vary according to the geographic region, leading to different levels of toxicity and clinical gastric manifestations. Through an integrative review of the literature we analyzed the clinical/epidemiological studies published between 2015 and 2020 in the LILACS, Scielo and PubMed databases, aiming to gather the most recent and important data on the various polymorphisms in the factors of virulence cagA and vacA and gastroduodenal clinical outcomes. Nineteen studies were identified that contemplated the objective of this review and a great variety of polymorphisms and genetic combinations of these virulence factors were observed in association with several clinical outcomes. It was also noted the existence of genetic profiles of prevalence of H. pylori strains and associations with distinct gastric pathologies in certain geographical regions. Although some conflicting results were identified, the understanding of these findings and the identification of possible contributing genes in gastric pathologies may serve as markers for the development of strategies for the prevention of these pathologies and better treatment efficacy.Los factores de virulencia cagA y vacA están estrechamente relacionados con la patogenicidad de Helicobacter pylori. Estos factores están ampliamente estudiados y se asocian a un mayor riesgo de desarrollar varios resultados clínicos gastroduodenales, como el cáncer gástrico. Además de presentar varios polimorfismos genéticos, que pueden variar según la región geográfica, dando lugar a diferentes niveles de toxicidad y manifestaciones clínicas gástricas. A través de una revisión integradora de la literatura se analizaron los estudios clínicos/epidemiológicos publicados entre 2015 y 2020 en las bases de datos LILACS, Scielo y PubMed, con el objetivo de reunir los datos más recientes e importantes sobre los distintos polimorfismos en los factores de virulencia cagA y vacA y los resultados clínicos gastroduodenales. Se identificaron 19 estudios que abordaron el objetivo de esta revisión y se observó una amplia variedad de polimorfismos y combinaciones genéticas de estos factores de virulencia en asociación con varios resultados clínicos. También se observó la existencia de perfiles genéticos de prevalencia de cepas de H. pylori y de asociaciones con distintas patologías gástricas en determinadas regiones geográficas. Aunque se identificaron algunos resultados contradictorios, la comprensión de estos hallazgos y la identificación de los posibles genes que contribuyen a las patologías gástricas pueden servir como marcadores para el desarrollo de estrategias para la prevención de estas patologías y una mejor eficacia del tratamiento.Os fatores de virulência cagA e vacA, estão intimamente relacionados a patogenicidade da Helicobacter pylori. Estes fatores são amplamente estudados e associados com um maior risco de desenvolvimento de diversos desfechos clínicos gastroduodenais, como o câncer gástrico. Além de apresentarem diversos polimorfismos genéticos, que podem variar de acordo com a região geográfica, acarretando em diferentes níveis de toxicidade e manifestações clínicas gástricas. Através de uma revisão integrativa da literatura analisou-se os estudos clínicos/epidemiológicos publicados entre 2015 e 2020, nas bases de dados LILACS, Scielo e PubMed, objetivando reunir os dados mais recentes e importantes sobre os diversos polimorfismos nos fatores de virulência cagA e vacA e os desfechos clínicos gastroduodenais. Foram identificados 19 estudos que contemplavam o objetivo desta revisão e foi observada uma grande variedade de polimorfismos e combinações genéticas destes fatores de virulência em associação com diversos desfechos clínicos. Notou-se também, a existência de perfis genéticos de prevalência das cepas de H. pylori e associações com as patologias gástricas distintas em certas regiões geográficas. Apesar de identificados alguns resultados conflitantes, a compreensão destes achados e a identificação dos possíveis genes contribuintes nas patologias gástricas, podem servir como marcadores para o desenvolvimento de estratégias para a prevenção dessas patologias e melhor eficácia do tratamento.Research, Society and Development2021-04-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1293810.33448/rsd-v10i4.12938Research, Society and Development; Vol. 10 No. 4; e28610412938Research, Society and Development; Vol. 10 Núm. 4; e28610412938Research, Society and Development; v. 10 n. 4; e286104129382525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/12938/12553Copyright (c) 2021 Cleiton Moreira Santana; Raíssa Lima Santos; Tarciso de Figueiredo Palma; Ana Carolina Santana de Oliveirahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSantana, Cleiton MoreiraSantos, Raíssa LimaPalma, Tarciso de FigueiredoOliveira, Ana Carolina Santana de2021-04-25T11:21:26Zoai:ojs.pkp.sfu.ca:article/12938Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:34:23.338941Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv The consequence of genetic polymorphisms of cagA and vacA virulence factors on gastroduodenal disorders affected by Helicobacter pylori
La consecuencia de los polimorfismos genéticos de los factores de virulencia cagA y vacA en los trastornos gastroduodenales afectados por el Helicobacter pylori
A consequência dos polimorfismos genéticos dos fatores de virulência cagA e vacA nas desordens gastroduodenais acometidas por Helicobacter pylori
title The consequence of genetic polymorphisms of cagA and vacA virulence factors on gastroduodenal disorders affected by Helicobacter pylori
spellingShingle The consequence of genetic polymorphisms of cagA and vacA virulence factors on gastroduodenal disorders affected by Helicobacter pylori
Santana, Cleiton Moreira
Helicobacter pylori
Factores de virulência
CagA
VacA
Gastropatías.
Helicobacter pylori
Virulence factors
CagA
VacA
Gastropathies.
Helicobacter pylori
CagA
VacA
Gastropatias.
title_short The consequence of genetic polymorphisms of cagA and vacA virulence factors on gastroduodenal disorders affected by Helicobacter pylori
title_full The consequence of genetic polymorphisms of cagA and vacA virulence factors on gastroduodenal disorders affected by Helicobacter pylori
title_fullStr The consequence of genetic polymorphisms of cagA and vacA virulence factors on gastroduodenal disorders affected by Helicobacter pylori
title_full_unstemmed The consequence of genetic polymorphisms of cagA and vacA virulence factors on gastroduodenal disorders affected by Helicobacter pylori
title_sort The consequence of genetic polymorphisms of cagA and vacA virulence factors on gastroduodenal disorders affected by Helicobacter pylori
author Santana, Cleiton Moreira
author_facet Santana, Cleiton Moreira
Santos, Raíssa Lima
Palma, Tarciso de Figueiredo
Oliveira, Ana Carolina Santana de
author_role author
author2 Santos, Raíssa Lima
Palma, Tarciso de Figueiredo
Oliveira, Ana Carolina Santana de
author2_role author
author
author
dc.contributor.author.fl_str_mv Santana, Cleiton Moreira
Santos, Raíssa Lima
Palma, Tarciso de Figueiredo
Oliveira, Ana Carolina Santana de
dc.subject.por.fl_str_mv Helicobacter pylori
Factores de virulência
CagA
VacA
Gastropatías.
Helicobacter pylori
Virulence factors
CagA
VacA
Gastropathies.
Helicobacter pylori
CagA
VacA
Gastropatias.
topic Helicobacter pylori
Factores de virulência
CagA
VacA
Gastropatías.
Helicobacter pylori
Virulence factors
CagA
VacA
Gastropathies.
Helicobacter pylori
CagA
VacA
Gastropatias.
description The virulence factors cagA and vacA, are closely related to the pathogenicity of Helicobacter pylori. These factors are widely studied and associated with a higher risk of developing several gastroduodenal clinical outcomes, such as gastric cancer. Besides presenting several genetic polymorphisms, which can vary according to the geographic region, leading to different levels of toxicity and clinical gastric manifestations. Through an integrative review of the literature we analyzed the clinical/epidemiological studies published between 2015 and 2020 in the LILACS, Scielo and PubMed databases, aiming to gather the most recent and important data on the various polymorphisms in the factors of virulence cagA and vacA and gastroduodenal clinical outcomes. Nineteen studies were identified that contemplated the objective of this review and a great variety of polymorphisms and genetic combinations of these virulence factors were observed in association with several clinical outcomes. It was also noted the existence of genetic profiles of prevalence of H. pylori strains and associations with distinct gastric pathologies in certain geographical regions. Although some conflicting results were identified, the understanding of these findings and the identification of possible contributing genes in gastric pathologies may serve as markers for the development of strategies for the prevention of these pathologies and better treatment efficacy.
publishDate 2021
dc.date.none.fl_str_mv 2021-04-04
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/12938
10.33448/rsd-v10i4.12938
url https://rsdjournal.org/index.php/rsd/article/view/12938
identifier_str_mv 10.33448/rsd-v10i4.12938
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/12938/12553
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 4; e28610412938
Research, Society and Development; Vol. 10 Núm. 4; e28610412938
Research, Society and Development; v. 10 n. 4; e28610412938
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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