Acetylcysteine in random skin flap in rats

Detalhes bibliográficos
Autor(a) principal: Abla, Luiz Eduardo Felipe [UNIFESP]
Data de Publicação: 2005
Outros Autores: Gomes, Heitor Carvalho [UNIFESP], Percario, Sandro [UNIFESP], Ferreira, Lydia Masako [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0102-86502005000200004
http://repositorio.unifesp.br/handle/11600/2456
Resumo: PURPOSE: Analyze the ability of Acetylcysteine to reduce distal necrosis in a random skin flap, in the rat. METHODS: The present study utilized 28 adult male Wistar-EPM rats distributed, at random, in two groups of 14 animals. Control group rats (CG) received distilled water and Acetylcysteine group animals (NACG) received NAC (300 mg/kg) by oral infusion, 15 minutes before flap elevation. On the seventh postoperative day, percentage of distal necrosis was determined and skin samples collected in order to allow determination of MDA levels. RESULTS: The mean necrotic area in CG group (control) was 66 % and in NACG group (Acetylcysteine) 52 %, a statistically significant difference according to the Mann-Whitney test (U calc = 25; U crit = 45). MDA levels were lower in the CG flap skin samples than in the NACG samples (U calc = 24; U crit = 45), the oposite being true in the normal skin samples (U calc = 10; U crit = 45). CONCLUSION: Acetylcysteine was effective, according to the model used, reducing the percentage of distal necrosis in NACG rats.
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spelling Acetylcysteine in random skin flap in ratsAcetilcisteína em retalho cutâneo randômico em ratosSurgical FlapsLipid peroxidationAcetylcysteineRatsRetalhos CirúrgicosPeroxidação de LipídeosAcetilcisteínaRatosPURPOSE: Analyze the ability of Acetylcysteine to reduce distal necrosis in a random skin flap, in the rat. METHODS: The present study utilized 28 adult male Wistar-EPM rats distributed, at random, in two groups of 14 animals. Control group rats (CG) received distilled water and Acetylcysteine group animals (NACG) received NAC (300 mg/kg) by oral infusion, 15 minutes before flap elevation. On the seventh postoperative day, percentage of distal necrosis was determined and skin samples collected in order to allow determination of MDA levels. RESULTS: The mean necrotic area in CG group (control) was 66 % and in NACG group (Acetylcysteine) 52 %, a statistically significant difference according to the Mann-Whitney test (U calc = 25; U crit = 45). MDA levels were lower in the CG flap skin samples than in the NACG samples (U calc = 24; U crit = 45), the oposite being true in the normal skin samples (U calc = 10; U crit = 45). CONCLUSION: Acetylcysteine was effective, according to the model used, reducing the percentage of distal necrosis in NACG rats.OBJETIVO: Analisar a capacidade da Acetilcisteína em reduzir a necrose distal em um retalho cutâneo randômico, no rato. MÉTODO: O presente trabalho utilizou 28 ratos machos adultos Wistar-EPM divididos, ao acaso, em dois grupos de 14 animais. Os ratos do grupo controle (CG) receberam água destilada e os animais do grupo Acetilcisteína (NACG) receberam NAC (300 mg/kg) por infusão oral, 15 minutos antes da elevação do retalho. No sétimo dia de pós-operatório, a porcentagem de necrose distal foi determinada e amostras de pele colhidas para permitir a determinação dos níveis de MDA. RESULTADOS: A área média de necrose no grupo CG (controle) foi 66 % e no grupo NACG (Acetilcisteína) 52 %, uma diferença estatisticamente significante de acordo com o teste de Mann-Whitney (U calc = 25; U crit = 45). Os níveis de MDA foram menores nas amostras de pele do retalho no grupo CG do que nas amostras do grupo NACG (U calc = 24; U crit = 45), o oposto sendo verdadeiro nas amostras de pele normal (U calc = 10; U crit = 45). CONCLUSÃO: A Acetilcisteína foi eficaz, de acordo com o modelo usado, reduzindo a porcentagem de necrose distal nos ratos NACG.UNIFESP Plastic Surgery DivisionUNIFESPUNIFESP, Plastic Surgery DivisionUNIFESPSciELOSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaUniversidade Federal de São Paulo (UNIFESP)Abla, Luiz Eduardo Felipe [UNIFESP]Gomes, Heitor Carvalho [UNIFESP]Percario, Sandro [UNIFESP]Ferreira, Lydia Masako [UNIFESP]2015-06-14T13:31:30Z2015-06-14T13:31:30Z2005-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion121-123application/pdfhttp://dx.doi.org/10.1590/S0102-86502005000200004Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 20, n. 2, p. 121-123, 2005.10.1590/S0102-86502005000200004S0102-86502005000200004.pdf0102-8650S0102-86502005000200004http://repositorio.unifesp.br/handle/11600/2456engActa Cirurgica Brasileirainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-28T09:12:02Zoai:repositorio.unifesp.br/:11600/2456Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-28T09:12:02Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Acetylcysteine in random skin flap in rats
Acetilcisteína em retalho cutâneo randômico em ratos
title Acetylcysteine in random skin flap in rats
spellingShingle Acetylcysteine in random skin flap in rats
Abla, Luiz Eduardo Felipe [UNIFESP]
Surgical Flaps
Lipid peroxidation
Acetylcysteine
Rats
Retalhos Cirúrgicos
Peroxidação de Lipídeos
Acetilcisteína
Ratos
title_short Acetylcysteine in random skin flap in rats
title_full Acetylcysteine in random skin flap in rats
title_fullStr Acetylcysteine in random skin flap in rats
title_full_unstemmed Acetylcysteine in random skin flap in rats
title_sort Acetylcysteine in random skin flap in rats
author Abla, Luiz Eduardo Felipe [UNIFESP]
author_facet Abla, Luiz Eduardo Felipe [UNIFESP]
Gomes, Heitor Carvalho [UNIFESP]
Percario, Sandro [UNIFESP]
Ferreira, Lydia Masako [UNIFESP]
author_role author
author2 Gomes, Heitor Carvalho [UNIFESP]
Percario, Sandro [UNIFESP]
Ferreira, Lydia Masako [UNIFESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Abla, Luiz Eduardo Felipe [UNIFESP]
Gomes, Heitor Carvalho [UNIFESP]
Percario, Sandro [UNIFESP]
Ferreira, Lydia Masako [UNIFESP]
dc.subject.por.fl_str_mv Surgical Flaps
Lipid peroxidation
Acetylcysteine
Rats
Retalhos Cirúrgicos
Peroxidação de Lipídeos
Acetilcisteína
Ratos
topic Surgical Flaps
Lipid peroxidation
Acetylcysteine
Rats
Retalhos Cirúrgicos
Peroxidação de Lipídeos
Acetilcisteína
Ratos
description PURPOSE: Analyze the ability of Acetylcysteine to reduce distal necrosis in a random skin flap, in the rat. METHODS: The present study utilized 28 adult male Wistar-EPM rats distributed, at random, in two groups of 14 animals. Control group rats (CG) received distilled water and Acetylcysteine group animals (NACG) received NAC (300 mg/kg) by oral infusion, 15 minutes before flap elevation. On the seventh postoperative day, percentage of distal necrosis was determined and skin samples collected in order to allow determination of MDA levels. RESULTS: The mean necrotic area in CG group (control) was 66 % and in NACG group (Acetylcysteine) 52 %, a statistically significant difference according to the Mann-Whitney test (U calc = 25; U crit = 45). MDA levels were lower in the CG flap skin samples than in the NACG samples (U calc = 24; U crit = 45), the oposite being true in the normal skin samples (U calc = 10; U crit = 45). CONCLUSION: Acetylcysteine was effective, according to the model used, reducing the percentage of distal necrosis in NACG rats.
publishDate 2005
dc.date.none.fl_str_mv 2005-04-01
2015-06-14T13:31:30Z
2015-06-14T13:31:30Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0102-86502005000200004
Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 20, n. 2, p. 121-123, 2005.
10.1590/S0102-86502005000200004
S0102-86502005000200004.pdf
0102-8650
S0102-86502005000200004
http://repositorio.unifesp.br/handle/11600/2456
url http://dx.doi.org/10.1590/S0102-86502005000200004
http://repositorio.unifesp.br/handle/11600/2456
identifier_str_mv Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 20, n. 2, p. 121-123, 2005.
10.1590/S0102-86502005000200004
S0102-86502005000200004.pdf
0102-8650
S0102-86502005000200004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Acta Cirurgica Brasileira
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 121-123
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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