Gastrinaemia and G-cell density in the antral gastrocystoplasty: an experimental study in rats

• Autor(a) principal: Ortiz, Valdemar [UNIFESP]
• Data de Publicação: 2000
• Outros Autores: Goldenberg, Saul [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• dARK ID: ark:/48912/001300000rgcm
• Texto Completo: http://dx.doi.org/10.1046/j.1464-410x.2000.00472.x; http://repositorio.unifesp.br/handle/11600/26253
• topic: gastrocystoplasty; gastrin; gastric antrum; G cells; bladder augmentation

Objective To evaluate gastrinaemia and G-cell density in the antrum incorporated into the bladder of rats after antrocystoplasty.Materials and methods Thirty-two adult, female Wistar EPM-1 rats (body weight 200-220 g) were divided into four equal groups that underwent; group 1, no treatment (controls); group 2, a sham operation: group 3, antrectomy; and group 4, antrocystoplasty. the rats were assessed 2 months after treatment, and gastrinaemia and the G-cell density determined in the antrum mucosa incorporated into the bladder,Results Compared with group 1, serum gastrin was significantly lower in group 3 (P<0.05) and the G-cell density lower in group 4 (P<0.05), although there was no decrease in gastrinaemia in group 4,Conclusion Antrocystoplasty in rats did not affect gastrinaemia but reduced the number of G cells in the antrum incorporated into the bladder.