Unraveling the role of high-intensity resistance training on left ventricle proteome: Is there a shift towards maladaptation?
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1016/j.lfs.2016.03.040 https://repositorio.unifesp.br/handle/11600/55979 |
Resumo: | High-intensity resistance training (RT) induces adaptations that improve physiological function. However, high intensity, volume and/or frequency may lead to injury and other health issues such as adverse cardiac effects. The aim of this study was to evaluate the effect of RT on left ventricle proteome, and to identify the pathways involved on the harmful adaptations induced by this protocol. Male Wistar rats were randomized into 2 groups: Trained (T) and Sedentary (S). Animals from T group were trained for 6 weeks, and then all the animals were sacrificed and left ventricle was isolated for analysis. We identified 955 proteins, and 93 proteins were considered |
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Unraveling the role of high-intensity resistance training on left ventricle proteome: Is there a shift towards maladaptation?Proteomics shotgunRat proteomicsHigh-intensity resistance trainingCardiac hypertrophyPathological hypertrophyHigh-intensity resistance training (RT) induces adaptations that improve physiological function. However, high intensity, volume and/or frequency may lead to injury and other health issues such as adverse cardiac effects. The aim of this study was to evaluate the effect of RT on left ventricle proteome, and to identify the pathways involved on the harmful adaptations induced by this protocol. Male Wistar rats were randomized into 2 groups: Trained (T) and Sedentary (S). Animals from T group were trained for 6 weeks, and then all the animals were sacrificed and left ventricle was isolated for analysis. We identified 955 proteins, and 93 proteins were considered36 were expressed exclusively in T group, and 4 in S group. Based on quantitative analysis, 42 proteins were found overexpressed and 11 underexpressed in T group compared with S group. Using the Gene Ontology to relate the biological processes in which these proteins are involved, we conclude that RT protocol promotes changes similar to those found in the initial phase of heart failure, but we also observed a concomitant increased expression of protective proteins, suggesting the activation of pathways to avoid major damages on left ventricle and delay the onset of pathological hypertrophy. Statement of significance of the study: Our study shows that high-intensity RT protocol changes left ventricle proteome, modifying metabolic profile of heart tissue and inducing the expression of proteins that acts against cardiac injury. We hypothesize that these adaptations occur to prevent the onset of cardiac dysfunction. Despite highly significant, it remains to be determined whether these adaptations are sufficient to further keep left ventricle function and exert cardioprotection, and whether this panel will be shifted towards maladaptation, and heart failure. (c) 2016 Elsevier Inc. All rights reserved.Fed Univ Sao Paulo UNIFESP, Dept Med, Discipline Nephrol, Sao Paulo, SP, BrazilFed Univ Sao Paulo UNIFESP, Dept Physiol, Discipline Nutr Physiol, Sao Paulo, SP, BrazilFed Univ Sao Paulo UNIFESP, Dept Med, Discipline Infect Dis, Special Mycol Lab LEMI, Sao Paulo, SP, BrazilUniv Estadual Campinas, Fac Dent Piracicaba FOP UNICAMP, Dept Physiol Sci, Piracicaba, SP, BrazilFed Univ Sao Paulo UNIFESP, Inst Sci & Technol, Dept Sci & Technol, BR-12231280 Sao Jose Dos Campos, SP, BrazilFed Univ Sao Paulo UNIFESP, Dept Med, Discipline Nephrol, Sao Paulo, SP, BrazilFed Univ Sao Paulo UNIFESP, Dept Physiol, Discipline Nutr Physiol, Sao Paulo, SP, BrazilFed Univ Sao Paulo UNIFESP, Dept Med, Discipline Infect Dis, Special Mycol Lab LEMI, Sao Paulo, SP, BrazilFed Univ Sao Paulo UNIFESP, Inst Sci & Technol, Dept Sci & Technol, BR-12231280 Sao Jose Dos Campos, SP, BrazilWeb of ScienceFundacao de Amparo a Pesquisa do Estado de Sao Paulo-FAPESPFAEP/UNICAMPCAPES, BrazilFAPESP: 02/05427-8FAEP/UNICAMP: 398/03FAEP/UNICAMP: 680/03Pergamon-Elsevier Science Ltd2020-07-22T13:23:00Z2020-07-22T13:23:00Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion156-164http://dx.doi.org/10.1016/j.lfs.2016.03.040Life Sciences. Oxford, v. 152, p. 156-164, 2016.10.1016/j.lfs.2016.03.0400024-3205https://repositorio.unifesp.br/handle/11600/55979WOS:000375728500019engLife SciencesOxfordinfo:eu-repo/semantics/openAccessDantas, Patricia Sousa [UNIFESP]Sakata, Maisa Mayumi [UNIFESP]Perez, Juliana Dineia [UNIFESP]Watanabe, Regina Lucia Harumi [UNIFESP]Bizerra, Fernando Cesar [UNIFESP]Neves, Vander Jose dasGuzzoni, ViniciusMarcondes, Fernanda KleinCasarini, Dulce Elena [UNIFESP]Cunha, Tatiana Sousa [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2021-09-29T09:32:03Zoai:repositorio.unifesp.br/:11600/55979Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652021-09-29T09:32:03Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Unraveling the role of high-intensity resistance training on left ventricle proteome: Is there a shift towards maladaptation? |
title |
Unraveling the role of high-intensity resistance training on left ventricle proteome: Is there a shift towards maladaptation? |
spellingShingle |
Unraveling the role of high-intensity resistance training on left ventricle proteome: Is there a shift towards maladaptation? Dantas, Patricia Sousa [UNIFESP] Proteomics shotgun Rat proteomics High-intensity resistance training Cardiac hypertrophy Pathological hypertrophy |
title_short |
Unraveling the role of high-intensity resistance training on left ventricle proteome: Is there a shift towards maladaptation? |
title_full |
Unraveling the role of high-intensity resistance training on left ventricle proteome: Is there a shift towards maladaptation? |
title_fullStr |
Unraveling the role of high-intensity resistance training on left ventricle proteome: Is there a shift towards maladaptation? |
title_full_unstemmed |
Unraveling the role of high-intensity resistance training on left ventricle proteome: Is there a shift towards maladaptation? |
title_sort |
Unraveling the role of high-intensity resistance training on left ventricle proteome: Is there a shift towards maladaptation? |
author |
Dantas, Patricia Sousa [UNIFESP] |
author_facet |
Dantas, Patricia Sousa [UNIFESP] Sakata, Maisa Mayumi [UNIFESP] Perez, Juliana Dineia [UNIFESP] Watanabe, Regina Lucia Harumi [UNIFESP] Bizerra, Fernando Cesar [UNIFESP] Neves, Vander Jose das Guzzoni, Vinicius Marcondes, Fernanda Klein Casarini, Dulce Elena [UNIFESP] Cunha, Tatiana Sousa [UNIFESP] |
author_role |
author |
author2 |
Sakata, Maisa Mayumi [UNIFESP] Perez, Juliana Dineia [UNIFESP] Watanabe, Regina Lucia Harumi [UNIFESP] Bizerra, Fernando Cesar [UNIFESP] Neves, Vander Jose das Guzzoni, Vinicius Marcondes, Fernanda Klein Casarini, Dulce Elena [UNIFESP] Cunha, Tatiana Sousa [UNIFESP] |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Dantas, Patricia Sousa [UNIFESP] Sakata, Maisa Mayumi [UNIFESP] Perez, Juliana Dineia [UNIFESP] Watanabe, Regina Lucia Harumi [UNIFESP] Bizerra, Fernando Cesar [UNIFESP] Neves, Vander Jose das Guzzoni, Vinicius Marcondes, Fernanda Klein Casarini, Dulce Elena [UNIFESP] Cunha, Tatiana Sousa [UNIFESP] |
dc.subject.por.fl_str_mv |
Proteomics shotgun Rat proteomics High-intensity resistance training Cardiac hypertrophy Pathological hypertrophy |
topic |
Proteomics shotgun Rat proteomics High-intensity resistance training Cardiac hypertrophy Pathological hypertrophy |
description |
High-intensity resistance training (RT) induces adaptations that improve physiological function. However, high intensity, volume and/or frequency may lead to injury and other health issues such as adverse cardiac effects. The aim of this study was to evaluate the effect of RT on left ventricle proteome, and to identify the pathways involved on the harmful adaptations induced by this protocol. Male Wistar rats were randomized into 2 groups: Trained (T) and Sedentary (S). Animals from T group were trained for 6 weeks, and then all the animals were sacrificed and left ventricle was isolated for analysis. We identified 955 proteins, and 93 proteins were considered |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016 2020-07-22T13:23:00Z 2020-07-22T13:23:00Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.lfs.2016.03.040 Life Sciences. Oxford, v. 152, p. 156-164, 2016. 10.1016/j.lfs.2016.03.040 0024-3205 https://repositorio.unifesp.br/handle/11600/55979 WOS:000375728500019 |
url |
http://dx.doi.org/10.1016/j.lfs.2016.03.040 https://repositorio.unifesp.br/handle/11600/55979 |
identifier_str_mv |
Life Sciences. Oxford, v. 152, p. 156-164, 2016. 10.1016/j.lfs.2016.03.040 0024-3205 WOS:000375728500019 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Life Sciences |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
156-164 |
dc.coverage.none.fl_str_mv |
Oxford |
dc.publisher.none.fl_str_mv |
Pergamon-Elsevier Science Ltd |
publisher.none.fl_str_mv |
Pergamon-Elsevier Science Ltd |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1814268297875554304 |