Apolipoprotein E polymorphisms and sleep quality in Obstructive Sleep Apnea Syndrome
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/34228 http://dx.doi.org/10.1016/j.cca.2011.08.007 |
Resumo: | Background: the purpose of this study was to evaluate the influence of polymorphism on sleep parameters of Obstructive Sleep Apnea Syndrome (OSAS) patients.Methods: Patients were genotyped after a full-night polysomnography using the large Epidemiologic Sleep Study of São Paulo population-based sample.Results: Individuals who carry the APOE epsilon 2 allele showed longer sleep latency, lower sleep efficiency and higher numbers of arousals/hour, when compared to epsilon 3 allele homozygous and carriers of epsilon 4 allele (p<0.05). These findings remained significant even after correction for potential confounders, such as sex, age and African genetic ancestry.Conclusion: the APOE polymorphisms may modulate the effects of intermittent hypoxia and sleep fragmentation in the sleep architecture of OSAS patients, and that the presence of the epsilon 2 allele may serve as a biological marker for the identification of a subgroup of patients who are more likely to suffer with OSAS detrimental effects on sleep, impacting not only the daily functioning, but also their quality of life. (C) 2011 Elsevier B.V. All rights reserved. |
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Pellegrino, Renata [UNIFESP]Mazzotti, Diego Robles [UNIFESP]Guindalini, Camila [UNIFESP]Santos-Silva, Rogerio [UNIFESP]Bittencourt, Lia Rita Azeredo [UNIFESP]Tufik, Sergio [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T14:17:27Z2016-01-24T14:17:27Z2011-11-20Clinica Chimica Acta. Amsterdam: Elsevier B.V., v. 412, n. 23-24, p. 2223-2227, 2011.0009-8981http://repositorio.unifesp.br/handle/11600/34228http://dx.doi.org/10.1016/j.cca.2011.08.007WOS000296686100034.pdf10.1016/j.cca.2011.08.007WOS:000296686100034Background: the purpose of this study was to evaluate the influence of polymorphism on sleep parameters of Obstructive Sleep Apnea Syndrome (OSAS) patients.Methods: Patients were genotyped after a full-night polysomnography using the large Epidemiologic Sleep Study of São Paulo population-based sample.Results: Individuals who carry the APOE epsilon 2 allele showed longer sleep latency, lower sleep efficiency and higher numbers of arousals/hour, when compared to epsilon 3 allele homozygous and carriers of epsilon 4 allele (p<0.05). These findings remained significant even after correction for potential confounders, such as sex, age and African genetic ancestry.Conclusion: the APOE polymorphisms may modulate the effects of intermittent hypoxia and sleep fragmentation in the sleep architecture of OSAS patients, and that the presence of the epsilon 2 allele may serve as a biological marker for the identification of a subgroup of patients who are more likely to suffer with OSAS detrimental effects on sleep, impacting not only the daily functioning, but also their quality of life. (C) 2011 Elsevier B.V. All rights reserved.Associacao Fundo de Incentivo a Psicofarmacologia (AFIP)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de São Paulo, Dept Psicobiol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, BrazilFAPESP: 07/50525-1FAPESP: 98/14303-3Web of Science2223-2227engElsevier B.V.Clinica Chimica Actahttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyinfo:eu-repo/semantics/openAccessApolipoprotein EDecreased sleep qualityObstructive Sleep Apnea SyndromePolysomnographySingle nucleotide polymorphismSleepApolipoprotein E polymorphisms and sleep quality in Obstructive Sleep Apnea Syndromeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000296686100034.pdfapplication/pdf398612${dspace.ui.url}/bitstream/11600/34228/1/WOS000296686100034.pdf8d8a03bf01ddabdc57b783923b570a09MD51open accessTEXTWOS000296686100034.pdf.txtWOS000296686100034.pdf.txtExtracted texttext/plain29319${dspace.ui.url}/bitstream/11600/34228/2/WOS000296686100034.pdf.txt9607026b76bafcf235c4ad9b587c1798MD52open access11600/342282022-11-04 15:40:34.109open accessoai:repositorio.unifesp.br:11600/34228Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:29:42.433788Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Apolipoprotein E polymorphisms and sleep quality in Obstructive Sleep Apnea Syndrome |
title |
Apolipoprotein E polymorphisms and sleep quality in Obstructive Sleep Apnea Syndrome |
spellingShingle |
Apolipoprotein E polymorphisms and sleep quality in Obstructive Sleep Apnea Syndrome Pellegrino, Renata [UNIFESP] Apolipoprotein E Decreased sleep quality Obstructive Sleep Apnea Syndrome Polysomnography Single nucleotide polymorphism Sleep |
title_short |
Apolipoprotein E polymorphisms and sleep quality in Obstructive Sleep Apnea Syndrome |
title_full |
Apolipoprotein E polymorphisms and sleep quality in Obstructive Sleep Apnea Syndrome |
title_fullStr |
Apolipoprotein E polymorphisms and sleep quality in Obstructive Sleep Apnea Syndrome |
title_full_unstemmed |
Apolipoprotein E polymorphisms and sleep quality in Obstructive Sleep Apnea Syndrome |
title_sort |
Apolipoprotein E polymorphisms and sleep quality in Obstructive Sleep Apnea Syndrome |
author |
Pellegrino, Renata [UNIFESP] |
author_facet |
Pellegrino, Renata [UNIFESP] Mazzotti, Diego Robles [UNIFESP] Guindalini, Camila [UNIFESP] Santos-Silva, Rogerio [UNIFESP] Bittencourt, Lia Rita Azeredo [UNIFESP] Tufik, Sergio [UNIFESP] |
author_role |
author |
author2 |
Mazzotti, Diego Robles [UNIFESP] Guindalini, Camila [UNIFESP] Santos-Silva, Rogerio [UNIFESP] Bittencourt, Lia Rita Azeredo [UNIFESP] Tufik, Sergio [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Pellegrino, Renata [UNIFESP] Mazzotti, Diego Robles [UNIFESP] Guindalini, Camila [UNIFESP] Santos-Silva, Rogerio [UNIFESP] Bittencourt, Lia Rita Azeredo [UNIFESP] Tufik, Sergio [UNIFESP] |
dc.subject.eng.fl_str_mv |
Apolipoprotein E Decreased sleep quality Obstructive Sleep Apnea Syndrome Polysomnography Single nucleotide polymorphism Sleep |
topic |
Apolipoprotein E Decreased sleep quality Obstructive Sleep Apnea Syndrome Polysomnography Single nucleotide polymorphism Sleep |
description |
Background: the purpose of this study was to evaluate the influence of polymorphism on sleep parameters of Obstructive Sleep Apnea Syndrome (OSAS) patients.Methods: Patients were genotyped after a full-night polysomnography using the large Epidemiologic Sleep Study of São Paulo population-based sample.Results: Individuals who carry the APOE epsilon 2 allele showed longer sleep latency, lower sleep efficiency and higher numbers of arousals/hour, when compared to epsilon 3 allele homozygous and carriers of epsilon 4 allele (p<0.05). These findings remained significant even after correction for potential confounders, such as sex, age and African genetic ancestry.Conclusion: the APOE polymorphisms may modulate the effects of intermittent hypoxia and sleep fragmentation in the sleep architecture of OSAS patients, and that the presence of the epsilon 2 allele may serve as a biological marker for the identification of a subgroup of patients who are more likely to suffer with OSAS detrimental effects on sleep, impacting not only the daily functioning, but also their quality of life. (C) 2011 Elsevier B.V. All rights reserved. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011-11-20 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:17:27Z |
dc.date.available.fl_str_mv |
2016-01-24T14:17:27Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Clinica Chimica Acta. Amsterdam: Elsevier B.V., v. 412, n. 23-24, p. 2223-2227, 2011. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/34228 http://dx.doi.org/10.1016/j.cca.2011.08.007 |
dc.identifier.issn.none.fl_str_mv |
0009-8981 |
dc.identifier.file.none.fl_str_mv |
WOS000296686100034.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.cca.2011.08.007 |
dc.identifier.wos.none.fl_str_mv |
WOS:000296686100034 |
identifier_str_mv |
Clinica Chimica Acta. Amsterdam: Elsevier B.V., v. 412, n. 23-24, p. 2223-2227, 2011. 0009-8981 WOS000296686100034.pdf 10.1016/j.cca.2011.08.007 WOS:000296686100034 |
url |
http://repositorio.unifesp.br/handle/11600/34228 http://dx.doi.org/10.1016/j.cca.2011.08.007 |
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eng |
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eng |
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Clinica Chimica Acta |
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http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy info:eu-repo/semantics/openAccess |
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http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
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openAccess |
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2223-2227 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
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Elsevier B.V. |
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