Neuroleptic Drugs Revert the Contextual Fear Conditioning Deficit Presented by Spontaneously Hypertensive Rats: A Potential Animal Model of Emotional Context Processing in Schizophrenia?
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/31613 http://dx.doi.org/10.1093/schbul/sbn006 |
Resumo: | Schizophrenia, bipolar disorder, and attention deficit/hyperactivity disorder (ADHD) present abnormalities in emotion processing. A previous study showed that the spontaneously hypertensive rats (SHR), a putative animal model of ADHD, present reduced contextual fear conditioning (CFC). the aim of the present study was to characterize the deficit in CFC presented by SHR. Adult male normotensive Wistar rats and SHR were submitted to the CFC task. Sensitivity of the animals to the shock and the CFC performance after repeated exposure to the task were investigated. Pharmacological characterization consisted in the evaluation of the effects of the following drugs administered previously to the acquisition of the CFC: pentylenetetrazole (anxiogenic) and chlordiazepoxide (anxiolytic); methylphenidate and amphetamine (used for ADHD); lamotrigine, carbamazepine, and valproic acid (mood stabilizers); haloperidol, ziprasidone, risperidone, amisulpride, and clozapine (neuroleptic drugs); metoclopramide and SCH 23390 (dopamine antagonists without antipsychotic properties); and ketamine (a psychotomimmetic). the effects of paradoxical sleep deprivation (that worsens psychotic symptoms) and the performance in a latent inhibition protocol (an animal model of schizophrenia) were also verified. No differences in the sensitivity to the shock were observed. the repeated exposure to the CFC task did not modify the deficit in CFC presented by SHR. Considering pharmacological treatments, only the neuroleptic drugs reversed this deficit. This deficit was potentiated by proschizophrenia manipulations. Finally, a deficit in latent inhibition was also presented by SHR. These findings suggest that the deficit in CFC presented by SHR could be a useful animal model to study abnormalities in emotional context processing related to schizophrenia. |
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Calzavara, Mariana Bendlin [UNIFESP]Medrano, Wladimir Agostini [UNIFESP]Levin, Raquel [UNIFESP]Kameda, Sonia Regina [UNIFESP]Andersen, Monica Levy [UNIFESP]Tufik, Sergio [UNIFESP]Silva, Regina HelenaFrussa-Filho, Roberto [UNIFESP]Abilio, Vanessa Costhek [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Univ Fed Rio Grande do Norte2016-01-24T13:52:39Z2016-01-24T13:52:39Z2009-07-01Schizophrenia Bulletin. Oxford: Oxford Univ Press, v. 35, n. 4, p. 748-759, 2009.0586-7614http://repositorio.unifesp.br/handle/11600/31613http://dx.doi.org/10.1093/schbul/sbn00610.1093/schbul/sbn006WOS:000268241700014Schizophrenia, bipolar disorder, and attention deficit/hyperactivity disorder (ADHD) present abnormalities in emotion processing. A previous study showed that the spontaneously hypertensive rats (SHR), a putative animal model of ADHD, present reduced contextual fear conditioning (CFC). the aim of the present study was to characterize the deficit in CFC presented by SHR. Adult male normotensive Wistar rats and SHR were submitted to the CFC task. Sensitivity of the animals to the shock and the CFC performance after repeated exposure to the task were investigated. Pharmacological characterization consisted in the evaluation of the effects of the following drugs administered previously to the acquisition of the CFC: pentylenetetrazole (anxiogenic) and chlordiazepoxide (anxiolytic); methylphenidate and amphetamine (used for ADHD); lamotrigine, carbamazepine, and valproic acid (mood stabilizers); haloperidol, ziprasidone, risperidone, amisulpride, and clozapine (neuroleptic drugs); metoclopramide and SCH 23390 (dopamine antagonists without antipsychotic properties); and ketamine (a psychotomimmetic). the effects of paradoxical sleep deprivation (that worsens psychotic symptoms) and the performance in a latent inhibition protocol (an animal model of schizophrenia) were also verified. No differences in the sensitivity to the shock were observed. the repeated exposure to the CFC task did not modify the deficit in CFC presented by SHR. Considering pharmacological treatments, only the neuroleptic drugs reversed this deficit. This deficit was potentiated by proschizophrenia manipulations. Finally, a deficit in latent inhibition was also presented by SHR. These findings suggest that the deficit in CFC presented by SHR could be a useful animal model to study abnormalities in emotional context processing related to schizophrenia.Universidade Federal de São Paulo, Dept Farmacol, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychobiol, BR-04023062 São Paulo, BrazilUniv Fed Rio Grande do Norte, Dept Physiol, BR-59072970 Natal, RN, BrazilUniversidade Federal de São Paulo, Dept Farmacol, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychobiol, BR-04023062 São Paulo, BrazilWeb of Science748-759engOxford Univ PressSchizophrenia Bulletinhttp://www.oxfordjournals.org/access_purchase/self-archiving_policyb.htmlinfo:eu-repo/semantics/openAccessratspsychiatric disorderemotional memoryantipsychoticsamphetaminemood stabilizersNeuroleptic Drugs Revert the Contextual Fear Conditioning Deficit Presented by Spontaneously Hypertensive Rats: A Potential Animal Model of Emotional Context Processing in Schizophrenia?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/316132023-01-12 21:39:40.549metadata only accessoai:repositorio.unifesp.br:11600/31613Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-01-13T00:39:40Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Neuroleptic Drugs Revert the Contextual Fear Conditioning Deficit Presented by Spontaneously Hypertensive Rats: A Potential Animal Model of Emotional Context Processing in Schizophrenia? |
title |
Neuroleptic Drugs Revert the Contextual Fear Conditioning Deficit Presented by Spontaneously Hypertensive Rats: A Potential Animal Model of Emotional Context Processing in Schizophrenia? |
spellingShingle |
Neuroleptic Drugs Revert the Contextual Fear Conditioning Deficit Presented by Spontaneously Hypertensive Rats: A Potential Animal Model of Emotional Context Processing in Schizophrenia? Calzavara, Mariana Bendlin [UNIFESP] rats psychiatric disorder emotional memory antipsychotics amphetamine mood stabilizers |
title_short |
Neuroleptic Drugs Revert the Contextual Fear Conditioning Deficit Presented by Spontaneously Hypertensive Rats: A Potential Animal Model of Emotional Context Processing in Schizophrenia? |
title_full |
Neuroleptic Drugs Revert the Contextual Fear Conditioning Deficit Presented by Spontaneously Hypertensive Rats: A Potential Animal Model of Emotional Context Processing in Schizophrenia? |
title_fullStr |
Neuroleptic Drugs Revert the Contextual Fear Conditioning Deficit Presented by Spontaneously Hypertensive Rats: A Potential Animal Model of Emotional Context Processing in Schizophrenia? |
title_full_unstemmed |
Neuroleptic Drugs Revert the Contextual Fear Conditioning Deficit Presented by Spontaneously Hypertensive Rats: A Potential Animal Model of Emotional Context Processing in Schizophrenia? |
title_sort |
Neuroleptic Drugs Revert the Contextual Fear Conditioning Deficit Presented by Spontaneously Hypertensive Rats: A Potential Animal Model of Emotional Context Processing in Schizophrenia? |
author |
Calzavara, Mariana Bendlin [UNIFESP] |
author_facet |
Calzavara, Mariana Bendlin [UNIFESP] Medrano, Wladimir Agostini [UNIFESP] Levin, Raquel [UNIFESP] Kameda, Sonia Regina [UNIFESP] Andersen, Monica Levy [UNIFESP] Tufik, Sergio [UNIFESP] Silva, Regina Helena Frussa-Filho, Roberto [UNIFESP] Abilio, Vanessa Costhek [UNIFESP] |
author_role |
author |
author2 |
Medrano, Wladimir Agostini [UNIFESP] Levin, Raquel [UNIFESP] Kameda, Sonia Regina [UNIFESP] Andersen, Monica Levy [UNIFESP] Tufik, Sergio [UNIFESP] Silva, Regina Helena Frussa-Filho, Roberto [UNIFESP] Abilio, Vanessa Costhek [UNIFESP] |
author2_role |
author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Univ Fed Rio Grande do Norte |
dc.contributor.author.fl_str_mv |
Calzavara, Mariana Bendlin [UNIFESP] Medrano, Wladimir Agostini [UNIFESP] Levin, Raquel [UNIFESP] Kameda, Sonia Regina [UNIFESP] Andersen, Monica Levy [UNIFESP] Tufik, Sergio [UNIFESP] Silva, Regina Helena Frussa-Filho, Roberto [UNIFESP] Abilio, Vanessa Costhek [UNIFESP] |
dc.subject.eng.fl_str_mv |
rats psychiatric disorder emotional memory antipsychotics amphetamine mood stabilizers |
topic |
rats psychiatric disorder emotional memory antipsychotics amphetamine mood stabilizers |
description |
Schizophrenia, bipolar disorder, and attention deficit/hyperactivity disorder (ADHD) present abnormalities in emotion processing. A previous study showed that the spontaneously hypertensive rats (SHR), a putative animal model of ADHD, present reduced contextual fear conditioning (CFC). the aim of the present study was to characterize the deficit in CFC presented by SHR. Adult male normotensive Wistar rats and SHR were submitted to the CFC task. Sensitivity of the animals to the shock and the CFC performance after repeated exposure to the task were investigated. Pharmacological characterization consisted in the evaluation of the effects of the following drugs administered previously to the acquisition of the CFC: pentylenetetrazole (anxiogenic) and chlordiazepoxide (anxiolytic); methylphenidate and amphetamine (used for ADHD); lamotrigine, carbamazepine, and valproic acid (mood stabilizers); haloperidol, ziprasidone, risperidone, amisulpride, and clozapine (neuroleptic drugs); metoclopramide and SCH 23390 (dopamine antagonists without antipsychotic properties); and ketamine (a psychotomimmetic). the effects of paradoxical sleep deprivation (that worsens psychotic symptoms) and the performance in a latent inhibition protocol (an animal model of schizophrenia) were also verified. No differences in the sensitivity to the shock were observed. the repeated exposure to the CFC task did not modify the deficit in CFC presented by SHR. Considering pharmacological treatments, only the neuroleptic drugs reversed this deficit. This deficit was potentiated by proschizophrenia manipulations. Finally, a deficit in latent inhibition was also presented by SHR. These findings suggest that the deficit in CFC presented by SHR could be a useful animal model to study abnormalities in emotional context processing related to schizophrenia. |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009-07-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T13:52:39Z |
dc.date.available.fl_str_mv |
2016-01-24T13:52:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Schizophrenia Bulletin. Oxford: Oxford Univ Press, v. 35, n. 4, p. 748-759, 2009. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/31613 http://dx.doi.org/10.1093/schbul/sbn006 |
dc.identifier.issn.none.fl_str_mv |
0586-7614 |
dc.identifier.doi.none.fl_str_mv |
10.1093/schbul/sbn006 |
dc.identifier.wos.none.fl_str_mv |
WOS:000268241700014 |
identifier_str_mv |
Schizophrenia Bulletin. Oxford: Oxford Univ Press, v. 35, n. 4, p. 748-759, 2009. 0586-7614 10.1093/schbul/sbn006 WOS:000268241700014 |
url |
http://repositorio.unifesp.br/handle/11600/31613 http://dx.doi.org/10.1093/schbul/sbn006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Schizophrenia Bulletin |
dc.rights.driver.fl_str_mv |
http://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
748-759 |
dc.publisher.none.fl_str_mv |
Oxford Univ Press |
publisher.none.fl_str_mv |
Oxford Univ Press |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764113457184768 |