Assessment of antioxidants status and superoxide dismutase activity in HIV-infected children

• Autor(a) principal: Pugliese, Camila [UNIFESP]
• Data de Publicação: 2014
• Outros Autores: Patin, Rose Vega [UNIFESP], Palchetti, Cecilia Zanin [UNIFESP], Claudio, Cristiane Chiantelli [UNIFESP], Gouvêa, Aida de Fátima Thomé Barbosa [UNIFESP], Succi, Regina Célia de Menezes [UNIFESP], Amancio, Olga Maria Silverio [UNIFESP], Cozzolino, Silvia Maria Franciscato, Oliveira, Fernanda Luisa Ceragioli [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1016/j.bjid.2014.02.003; http://repositorio.unifesp.br/handle/11600/38115
• topic: Antioxidants; HIV and nutrition; Oxidative stress; Trace elements

Objective: This study aims to assess the nutritional status of selenium, copper and zinc; and also the erythrocyte superoxide dismutase activity of HIV-infected children compared to a control group.Methods: A cross-sectional study was carried out with prepubertal HIV-infected children (n = 51) and their healthy siblings (n = 32). All biochemical measurements including plasma selenium, serum copper levels, serum and erythrocyte zinc levels and erythrocyte superoxide dismutase activity were evaluated according to dietary, clinical and biochemical parameters.Results: Compared to the control group, the HIV-infected children had lower z-score values for height-for-age (p = 0.0006), higher prevalence of stunting (11.8%) (p = 0.047), lower selenium levels (p = 0.0006) and higher copper levels (p = 0.019). No difference was found concerning superoxide dismutase activity (p > 0.05). the HIV-infected group presented a higher proportion (45.1%) of children with zinc intakes below the estimated average requirement (p = 0.014); however, no association with zinc biochemical parameters was found.Conclusion: HIV-infected children have an inadequate selenium and copper nutritional status, which could influence the progression to AIDS. An adequate micronutrient status could improve the clinical conditions in these patients and minimize free radical production and cellular oxidative stress. (C) 2014 Elsevier Editora Ltda. All rights reserved.