Juvenile myoclonic epilepsy: Challenges on its 60th anniversary

Detalhes bibliográficos
Autor(a) principal: Yacubian, Elza Márcia Targas [UNIFESP]
Data de Publicação: 2017
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1016/j.seizure.2016.09.005
https://repositorio.unifesp.br/handle/11600/56407
Resumo: Purpose: Since its initial 1957 description, juvenile myoclonic epilepsy (JME) has been recognized as a common epileptic syndrome worldwide. Methods: We reviewed a series of articles on JME to clarify challenges in clinical and pathophysiological findings, treatment and outcome. Results: Typical JME characteristics include: 1) the age at seizure onset between 10 and 25 years
id UFSP_db56ce54e53dbbfcbaa6bff56034cc52
oai_identifier_str oai:repositorio.unifesp.br/:11600/56407
network_acronym_str UFSP
network_name_str Repositório Institucional da UNIFESP
repository_id_str 3465
spelling Juvenile myoclonic epilepsy: Challenges on its 60th anniversaryJuvenile myoclonic epilepsyClinical expressionReflex traitsPathophysiologyTreatmentPrognosisPurpose: Since its initial 1957 description, juvenile myoclonic epilepsy (JME) has been recognized as a common epileptic syndrome worldwide. Methods: We reviewed a series of articles on JME to clarify challenges in clinical and pathophysiological findings, treatment and outcome. Results: Typical JME characteristics include: 1) the age at seizure onset between 10 and 25 years2) the triad of myoclonia, generalized tonic-clonic seizures, and absences, of which only myoclonia is a mandatory criterion3) cognitive dysfunction that may have impact on interpersonal relationships and social outcome4) possibility of seizure control in up to 80% of individuals, in particular with the use of sodium valproate5) a tendency for lifelong seizures with an early morning preponderance6) after decades from the clinical onset, a possibility to be off medications for a third of the patients, and 7) several prognostic factors. Conclusion: After 60 years, several challenges remain in this complex epileptic syndrome. (C) 2016 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.Univ Fed Sao Paulo, Dept Neurol & Neurosurg, Sao Paulo, BrazilDepartment of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, BrazilWeb of ScienceW B Saunders Co Ltd2020-07-31T12:46:51Z2020-07-31T12:46:51Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion48-52http://dx.doi.org/10.1016/j.seizure.2016.09.005Seizure-European Journal Of Epilepsy. London, v. 44, p. 48-52, 2017.10.1016/j.seizure.2016.09.0051059-1311https://repositorio.unifesp.br/handle/11600/56407WOS:000394472800010engSeizure-European Journal Of EpilepsyLondoninfo:eu-repo/semantics/openAccessYacubian, Elza Márcia Targas [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2022-02-08T12:11:58Zoai:repositorio.unifesp.br/:11600/56407Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652022-02-08T12:11:58Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Juvenile myoclonic epilepsy: Challenges on its 60th anniversary
title Juvenile myoclonic epilepsy: Challenges on its 60th anniversary
spellingShingle Juvenile myoclonic epilepsy: Challenges on its 60th anniversary
Yacubian, Elza Márcia Targas [UNIFESP]
Juvenile myoclonic epilepsy
Clinical expression
Reflex traits
Pathophysiology
Treatment
Prognosis
title_short Juvenile myoclonic epilepsy: Challenges on its 60th anniversary
title_full Juvenile myoclonic epilepsy: Challenges on its 60th anniversary
title_fullStr Juvenile myoclonic epilepsy: Challenges on its 60th anniversary
title_full_unstemmed Juvenile myoclonic epilepsy: Challenges on its 60th anniversary
title_sort Juvenile myoclonic epilepsy: Challenges on its 60th anniversary
author Yacubian, Elza Márcia Targas [UNIFESP]
author_facet Yacubian, Elza Márcia Targas [UNIFESP]
author_role author
dc.contributor.author.fl_str_mv Yacubian, Elza Márcia Targas [UNIFESP]
dc.subject.por.fl_str_mv Juvenile myoclonic epilepsy
Clinical expression
Reflex traits
Pathophysiology
Treatment
Prognosis
topic Juvenile myoclonic epilepsy
Clinical expression
Reflex traits
Pathophysiology
Treatment
Prognosis
description Purpose: Since its initial 1957 description, juvenile myoclonic epilepsy (JME) has been recognized as a common epileptic syndrome worldwide. Methods: We reviewed a series of articles on JME to clarify challenges in clinical and pathophysiological findings, treatment and outcome. Results: Typical JME characteristics include: 1) the age at seizure onset between 10 and 25 years
publishDate 2017
dc.date.none.fl_str_mv 2017
2020-07-31T12:46:51Z
2020-07-31T12:46:51Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.seizure.2016.09.005
Seizure-European Journal Of Epilepsy. London, v. 44, p. 48-52, 2017.
10.1016/j.seizure.2016.09.005
1059-1311
https://repositorio.unifesp.br/handle/11600/56407
WOS:000394472800010
url http://dx.doi.org/10.1016/j.seizure.2016.09.005
https://repositorio.unifesp.br/handle/11600/56407
identifier_str_mv Seizure-European Journal Of Epilepsy. London, v. 44, p. 48-52, 2017.
10.1016/j.seizure.2016.09.005
1059-1311
WOS:000394472800010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Seizure-European Journal Of Epilepsy
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 48-52
dc.coverage.none.fl_str_mv London
dc.publisher.none.fl_str_mv W B Saunders Co Ltd
publisher.none.fl_str_mv W B Saunders Co Ltd
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268397614006272

Registros relacionados