ESSENTIAL-HYPERTENSION AND HISTOCOMPATIBILITY ANTIGENS - AN ASSOCIATION STUDY
Autor(a) principal: | |
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Data de Publicação: | 1992 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://doi.org/10.1161/01.HYP.19.4.400 http://repositorio.unifesp.br/handle/11600/43817 |
Resumo: | Data from a previous study concerning the distribution of human leukocyte antigen (HLA) haplotypes in siblings with essential hypertension suggested that at least one of the genes responsible for the genetic susceptibility to this disease is located in or near the HLA complex. The objective of the present study was to investigate if a given HLA-A, B, or DR gene could represent a marker for susceptibility to essential hypertension at the population level. Thus, the frequencies of HLA antigens were determined in Caucasian patients with essential hypertension (HLA-A and B antigens were determined in 89 cases, 85 of which were also typed for HLA-DR antigens). The results showed an increased frequency (p = 0.00064) of HLA-DR4, which was present in 34% of the patients and in 16% of local ethnically matched control subjects. We conclude that HLA-DR4 may represent a marker for susceptibility to essential hypertension in the Brazilian Caucasian population. |
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Repositório Institucional da UNIFESP |
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ESSENTIAL-HYPERTENSION AND HISTOCOMPATIBILITY ANTIGENS - AN ASSOCIATION STUDYESSENTIAL HYPERTENSIONHLA ANTIGENSIMMUNOGENETICSHISTOCOMPATIBILITY ANTIGENSData from a previous study concerning the distribution of human leukocyte antigen (HLA) haplotypes in siblings with essential hypertension suggested that at least one of the genes responsible for the genetic susceptibility to this disease is located in or near the HLA complex. The objective of the present study was to investigate if a given HLA-A, B, or DR gene could represent a marker for susceptibility to essential hypertension at the population level. Thus, the frequencies of HLA antigens were determined in Caucasian patients with essential hypertension (HLA-A and B antigens were determined in 89 cases, 85 of which were also typed for HLA-DR antigens). The results showed an increased frequency (p = 0.00064) of HLA-DR4, which was present in 34% of the patients and in 16% of local ethnically matched control subjects. We conclude that HLA-DR4 may represent a marker for susceptibility to essential hypertension in the Brazilian Caucasian population.UNIV SAO PAULO,HOSP CLIN,FAC MED,ESCOLA PAULISTA MED,SAO PAULO,BRAZILUNIV SAO PAULO,HOSP CLIN,FAC MED,INST CORACAO,SAO PAULO,BRAZILUNIV SAO PAULO,HOSP CLIN,FAC MED,ESCOLA PAULISTA MED,SAO PAULO,BRAZILWeb of ScienceAmer Heart AssocUniversidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)Gerbase-Lima, Maria [UNIFESP]Ladalardo, Maria Antonia [UNIFESP]Delima, JJGSilva, H. B.Bellotti, G.Pileggi, F.2018-06-15T17:35:11Z2018-06-15T17:35:11Z1992-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion400-402https://doi.org/10.1161/01.HYP.19.4.400Hypertension. Dallas: Amer Heart Assoc, v. 19, n. 4, p. 400-402, 1992.10.1161/01.HYP.19.4.4000194-911Xhttp://repositorio.unifesp.br/handle/11600/43817WOS:A1992HM35400016engHypertensioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-05-02T13:59:17Zoai:repositorio.unifesp.br/:11600/43817Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-05-02T13:59:17Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
ESSENTIAL-HYPERTENSION AND HISTOCOMPATIBILITY ANTIGENS - AN ASSOCIATION STUDY |
title |
ESSENTIAL-HYPERTENSION AND HISTOCOMPATIBILITY ANTIGENS - AN ASSOCIATION STUDY |
spellingShingle |
ESSENTIAL-HYPERTENSION AND HISTOCOMPATIBILITY ANTIGENS - AN ASSOCIATION STUDY Gerbase-Lima, Maria [UNIFESP] ESSENTIAL HYPERTENSION HLA ANTIGENS IMMUNOGENETICS HISTOCOMPATIBILITY ANTIGENS |
title_short |
ESSENTIAL-HYPERTENSION AND HISTOCOMPATIBILITY ANTIGENS - AN ASSOCIATION STUDY |
title_full |
ESSENTIAL-HYPERTENSION AND HISTOCOMPATIBILITY ANTIGENS - AN ASSOCIATION STUDY |
title_fullStr |
ESSENTIAL-HYPERTENSION AND HISTOCOMPATIBILITY ANTIGENS - AN ASSOCIATION STUDY |
title_full_unstemmed |
ESSENTIAL-HYPERTENSION AND HISTOCOMPATIBILITY ANTIGENS - AN ASSOCIATION STUDY |
title_sort |
ESSENTIAL-HYPERTENSION AND HISTOCOMPATIBILITY ANTIGENS - AN ASSOCIATION STUDY |
author |
Gerbase-Lima, Maria [UNIFESP] |
author_facet |
Gerbase-Lima, Maria [UNIFESP] Ladalardo, Maria Antonia [UNIFESP] Delima, JJG Silva, H. B. Bellotti, G. Pileggi, F. |
author_role |
author |
author2 |
Ladalardo, Maria Antonia [UNIFESP] Delima, JJG Silva, H. B. Bellotti, G. Pileggi, F. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Gerbase-Lima, Maria [UNIFESP] Ladalardo, Maria Antonia [UNIFESP] Delima, JJG Silva, H. B. Bellotti, G. Pileggi, F. |
dc.subject.por.fl_str_mv |
ESSENTIAL HYPERTENSION HLA ANTIGENS IMMUNOGENETICS HISTOCOMPATIBILITY ANTIGENS |
topic |
ESSENTIAL HYPERTENSION HLA ANTIGENS IMMUNOGENETICS HISTOCOMPATIBILITY ANTIGENS |
description |
Data from a previous study concerning the distribution of human leukocyte antigen (HLA) haplotypes in siblings with essential hypertension suggested that at least one of the genes responsible for the genetic susceptibility to this disease is located in or near the HLA complex. The objective of the present study was to investigate if a given HLA-A, B, or DR gene could represent a marker for susceptibility to essential hypertension at the population level. Thus, the frequencies of HLA antigens were determined in Caucasian patients with essential hypertension (HLA-A and B antigens were determined in 89 cases, 85 of which were also typed for HLA-DR antigens). The results showed an increased frequency (p = 0.00064) of HLA-DR4, which was present in 34% of the patients and in 16% of local ethnically matched control subjects. We conclude that HLA-DR4 may represent a marker for susceptibility to essential hypertension in the Brazilian Caucasian population. |
publishDate |
1992 |
dc.date.none.fl_str_mv |
1992-04-01 2018-06-15T17:35:11Z 2018-06-15T17:35:11Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.1161/01.HYP.19.4.400 Hypertension. Dallas: Amer Heart Assoc, v. 19, n. 4, p. 400-402, 1992. 10.1161/01.HYP.19.4.400 0194-911X http://repositorio.unifesp.br/handle/11600/43817 WOS:A1992HM35400016 |
url |
https://doi.org/10.1161/01.HYP.19.4.400 http://repositorio.unifesp.br/handle/11600/43817 |
identifier_str_mv |
Hypertension. Dallas: Amer Heart Assoc, v. 19, n. 4, p. 400-402, 1992. 10.1161/01.HYP.19.4.400 0194-911X WOS:A1992HM35400016 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Hypertension |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
400-402 |
dc.publisher.none.fl_str_mv |
Amer Heart Assoc |
publisher.none.fl_str_mv |
Amer Heart Assoc |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268443083407360 |