ESSENTIAL-HYPERTENSION AND HISTOCOMPATIBILITY ANTIGENS - AN ASSOCIATION STUDY

Detalhes bibliográficos
Autor(a) principal: Gerbase-Lima, Maria [UNIFESP]
Data de Publicação: 1992
Outros Autores: Ladalardo, Maria Antonia [UNIFESP], Delima, JJG, Silva, H. B., Bellotti, G., Pileggi, F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: https://doi.org/10.1161/01.HYP.19.4.400
http://repositorio.unifesp.br/handle/11600/43817
Resumo: Data from a previous study concerning the distribution of human leukocyte antigen (HLA) haplotypes in siblings with essential hypertension suggested that at least one of the genes responsible for the genetic susceptibility to this disease is located in or near the HLA complex. The objective of the present study was to investigate if a given HLA-A, B, or DR gene could represent a marker for susceptibility to essential hypertension at the population level. Thus, the frequencies of HLA antigens were determined in Caucasian patients with essential hypertension (HLA-A and B antigens were determined in 89 cases, 85 of which were also typed for HLA-DR antigens). The results showed an increased frequency (p = 0.00064) of HLA-DR4, which was present in 34% of the patients and in 16% of local ethnically matched control subjects. We conclude that HLA-DR4 may represent a marker for susceptibility to essential hypertension in the Brazilian Caucasian population.
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spelling ESSENTIAL-HYPERTENSION AND HISTOCOMPATIBILITY ANTIGENS - AN ASSOCIATION STUDYESSENTIAL HYPERTENSIONHLA ANTIGENSIMMUNOGENETICSHISTOCOMPATIBILITY ANTIGENSData from a previous study concerning the distribution of human leukocyte antigen (HLA) haplotypes in siblings with essential hypertension suggested that at least one of the genes responsible for the genetic susceptibility to this disease is located in or near the HLA complex. The objective of the present study was to investigate if a given HLA-A, B, or DR gene could represent a marker for susceptibility to essential hypertension at the population level. Thus, the frequencies of HLA antigens were determined in Caucasian patients with essential hypertension (HLA-A and B antigens were determined in 89 cases, 85 of which were also typed for HLA-DR antigens). The results showed an increased frequency (p = 0.00064) of HLA-DR4, which was present in 34% of the patients and in 16% of local ethnically matched control subjects. We conclude that HLA-DR4 may represent a marker for susceptibility to essential hypertension in the Brazilian Caucasian population.UNIV SAO PAULO,HOSP CLIN,FAC MED,ESCOLA PAULISTA MED,SAO PAULO,BRAZILUNIV SAO PAULO,HOSP CLIN,FAC MED,INST CORACAO,SAO PAULO,BRAZILUNIV SAO PAULO,HOSP CLIN,FAC MED,ESCOLA PAULISTA MED,SAO PAULO,BRAZILWeb of ScienceAmer Heart AssocUniversidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)Gerbase-Lima, Maria [UNIFESP]Ladalardo, Maria Antonia [UNIFESP]Delima, JJGSilva, H. B.Bellotti, G.Pileggi, F.2018-06-15T17:35:11Z2018-06-15T17:35:11Z1992-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion400-402https://doi.org/10.1161/01.HYP.19.4.400Hypertension. Dallas: Amer Heart Assoc, v. 19, n. 4, p. 400-402, 1992.10.1161/01.HYP.19.4.4000194-911Xhttp://repositorio.unifesp.br/handle/11600/43817WOS:A1992HM35400016engHypertensioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-05-02T13:59:17Zoai:repositorio.unifesp.br/:11600/43817Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-05-02T13:59:17Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv ESSENTIAL-HYPERTENSION AND HISTOCOMPATIBILITY ANTIGENS - AN ASSOCIATION STUDY
title ESSENTIAL-HYPERTENSION AND HISTOCOMPATIBILITY ANTIGENS - AN ASSOCIATION STUDY
spellingShingle ESSENTIAL-HYPERTENSION AND HISTOCOMPATIBILITY ANTIGENS - AN ASSOCIATION STUDY
Gerbase-Lima, Maria [UNIFESP]
ESSENTIAL HYPERTENSION
HLA ANTIGENS
IMMUNOGENETICS
HISTOCOMPATIBILITY ANTIGENS
title_short ESSENTIAL-HYPERTENSION AND HISTOCOMPATIBILITY ANTIGENS - AN ASSOCIATION STUDY
title_full ESSENTIAL-HYPERTENSION AND HISTOCOMPATIBILITY ANTIGENS - AN ASSOCIATION STUDY
title_fullStr ESSENTIAL-HYPERTENSION AND HISTOCOMPATIBILITY ANTIGENS - AN ASSOCIATION STUDY
title_full_unstemmed ESSENTIAL-HYPERTENSION AND HISTOCOMPATIBILITY ANTIGENS - AN ASSOCIATION STUDY
title_sort ESSENTIAL-HYPERTENSION AND HISTOCOMPATIBILITY ANTIGENS - AN ASSOCIATION STUDY
author Gerbase-Lima, Maria [UNIFESP]
author_facet Gerbase-Lima, Maria [UNIFESP]
Ladalardo, Maria Antonia [UNIFESP]
Delima, JJG
Silva, H. B.
Bellotti, G.
Pileggi, F.
author_role author
author2 Ladalardo, Maria Antonia [UNIFESP]
Delima, JJG
Silva, H. B.
Bellotti, G.
Pileggi, F.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Gerbase-Lima, Maria [UNIFESP]
Ladalardo, Maria Antonia [UNIFESP]
Delima, JJG
Silva, H. B.
Bellotti, G.
Pileggi, F.
dc.subject.por.fl_str_mv ESSENTIAL HYPERTENSION
HLA ANTIGENS
IMMUNOGENETICS
HISTOCOMPATIBILITY ANTIGENS
topic ESSENTIAL HYPERTENSION
HLA ANTIGENS
IMMUNOGENETICS
HISTOCOMPATIBILITY ANTIGENS
description Data from a previous study concerning the distribution of human leukocyte antigen (HLA) haplotypes in siblings with essential hypertension suggested that at least one of the genes responsible for the genetic susceptibility to this disease is located in or near the HLA complex. The objective of the present study was to investigate if a given HLA-A, B, or DR gene could represent a marker for susceptibility to essential hypertension at the population level. Thus, the frequencies of HLA antigens were determined in Caucasian patients with essential hypertension (HLA-A and B antigens were determined in 89 cases, 85 of which were also typed for HLA-DR antigens). The results showed an increased frequency (p = 0.00064) of HLA-DR4, which was present in 34% of the patients and in 16% of local ethnically matched control subjects. We conclude that HLA-DR4 may represent a marker for susceptibility to essential hypertension in the Brazilian Caucasian population.
publishDate 1992
dc.date.none.fl_str_mv 1992-04-01
2018-06-15T17:35:11Z
2018-06-15T17:35:11Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.1161/01.HYP.19.4.400
Hypertension. Dallas: Amer Heart Assoc, v. 19, n. 4, p. 400-402, 1992.
10.1161/01.HYP.19.4.400
0194-911X
http://repositorio.unifesp.br/handle/11600/43817
WOS:A1992HM35400016
url https://doi.org/10.1161/01.HYP.19.4.400
http://repositorio.unifesp.br/handle/11600/43817
identifier_str_mv Hypertension. Dallas: Amer Heart Assoc, v. 19, n. 4, p. 400-402, 1992.
10.1161/01.HYP.19.4.400
0194-911X
WOS:A1992HM35400016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Hypertension
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 400-402
dc.publisher.none.fl_str_mv Amer Heart Assoc
publisher.none.fl_str_mv Amer Heart Assoc
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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