Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/1011 http://dx.doi.org/10.1590/S0066-782X2000000800005 |
Resumo: | OBJECTIVE: To assess by Doppler echocardiography the structural and functional alterations of rat heart with surgical induced extensive myocardial infarction. METHODS: Five weeks after surgical ligature of the left coronary artery, 38 Wistar-EPM rats of both sexes, 10 of them with extensive infarction, undergone anatomical and functional evaluation by Doppler echocardiography and then euthanized for anatomopathological analysis. RESULTS: Echocardiography was 100% sensible and specific to anatomopathological confirmed extensive miocardial infarction. Extensive infarction lead to dilatation of left ventricle (diastolic diameter: 0.89cm vs.0.64cm; systolic: 0.72cm vs. 0.33cm) and left atrium (0.55cm vs. 0.33cm); thinning of left ventricular anterior wall (systolic: 0.14cm vs. 0.23cm, diastolic: 0.11cm vs. 0.14cm); increased mitral E/ A wave relation (6.45 vs. 1.95). Signals of increased end diastolic ventricle pressure, B point in mitral valve tracing in 62.5% and signs of pulmonary hypertension straightening of pulmonary valve (90%) and notching of pulmonary systolic flow (60%) were observed in animals with extensive infarction. CONCLUSION: Doppler echocardiography has a high sensitivity and specificity for detection of chronic extensive infarction. Extensive infarction caused dilatation of left cardiac chambers and showed in Doppler signals of increased end diastolic left ventricular pressure and pulmonary artery pressure. |
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Moisés, Valdir Ambrósio [UNIFESP]Ferreira, Ricardo L. [UNIFESP]Nozawa, Emília [UNIFESP]Kanashiro-Takeuchi, Rosimeire Miyuki [UNIFESP]Campos Filho, Orlando [UNIFESP]Andrade, José Lazaro de [UNIFESP]Carvalho, Antonio Carlos [UNIFESP]Tucci, Paulo José Ferreira [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2015-06-14T13:25:06Z2015-06-14T13:25:06Z2000-08-01Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 75, n. 2, p. 131-136, 2000.0066-782Xhttp://repositorio.unifesp.br/handle/11600/1011http://dx.doi.org/10.1590/S0066-782X2000000800005S0066-782X2000000800005.pdfS0066-782X200000080000510.1590/S0066-782X2000000800005OBJECTIVE: To assess by Doppler echocardiography the structural and functional alterations of rat heart with surgical induced extensive myocardial infarction. METHODS: Five weeks after surgical ligature of the left coronary artery, 38 Wistar-EPM rats of both sexes, 10 of them with extensive infarction, undergone anatomical and functional evaluation by Doppler echocardiography and then euthanized for anatomopathological analysis. RESULTS: Echocardiography was 100% sensible and specific to anatomopathological confirmed extensive miocardial infarction. Extensive infarction lead to dilatation of left ventricle (diastolic diameter: 0.89cm vs.0.64cm; systolic: 0.72cm vs. 0.33cm) and left atrium (0.55cm vs. 0.33cm); thinning of left ventricular anterior wall (systolic: 0.14cm vs. 0.23cm, diastolic: 0.11cm vs. 0.14cm); increased mitral E/ A wave relation (6.45 vs. 1.95). Signals of increased end diastolic ventricle pressure, B point in mitral valve tracing in 62.5% and signs of pulmonary hypertension straightening of pulmonary valve (90%) and notching of pulmonary systolic flow (60%) were observed in animals with extensive infarction. CONCLUSION: Doppler echocardiography has a high sensitivity and specificity for detection of chronic extensive infarction. Extensive infarction caused dilatation of left cardiac chambers and showed in Doppler signals of increased end diastolic left ventricular pressure and pulmonary artery pressure.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de MedicinaUNIFESP, EPMSciELO131-136engSociedade Brasileira de Cardiologia - SBCArquivos Brasileiros de Cardiologiamyocardial infarctrat heartsDoppler echocardiogramStructural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiographyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0066-782X2000000800005.pdfapplication/pdf312052${dspace.ui.url}/bitstream/11600/1011/1/S0066-782X2000000800005.pdf071fa1255dddb641dce291b9221e4b5fMD51open accessTEXTS0066-782X2000000800005.pdf.txtS0066-782X2000000800005.pdf.txtExtracted texttext/plain27459${dspace.ui.url}/bitstream/11600/1011/2/S0066-782X2000000800005.pdf.txt2ca11d7a6bcbaa1328e9effbb76feddcMD52open access11600/10112022-06-02 10:24:15.148open accessoai:repositorio.unifesp.br:11600/1011Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:16:36.729528Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography |
title |
Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography |
spellingShingle |
Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography Moisés, Valdir Ambrósio [UNIFESP] myocardial infarct rat hearts Doppler echocardiogram |
title_short |
Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography |
title_full |
Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography |
title_fullStr |
Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography |
title_full_unstemmed |
Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography |
title_sort |
Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography |
author |
Moisés, Valdir Ambrósio [UNIFESP] |
author_facet |
Moisés, Valdir Ambrósio [UNIFESP] Ferreira, Ricardo L. [UNIFESP] Nozawa, Emília [UNIFESP] Kanashiro-Takeuchi, Rosimeire Miyuki [UNIFESP] Campos Filho, Orlando [UNIFESP] Andrade, José Lazaro de [UNIFESP] Carvalho, Antonio Carlos [UNIFESP] Tucci, Paulo José Ferreira [UNIFESP] |
author_role |
author |
author2 |
Ferreira, Ricardo L. [UNIFESP] Nozawa, Emília [UNIFESP] Kanashiro-Takeuchi, Rosimeire Miyuki [UNIFESP] Campos Filho, Orlando [UNIFESP] Andrade, José Lazaro de [UNIFESP] Carvalho, Antonio Carlos [UNIFESP] Tucci, Paulo José Ferreira [UNIFESP] |
author2_role |
author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Moisés, Valdir Ambrósio [UNIFESP] Ferreira, Ricardo L. [UNIFESP] Nozawa, Emília [UNIFESP] Kanashiro-Takeuchi, Rosimeire Miyuki [UNIFESP] Campos Filho, Orlando [UNIFESP] Andrade, José Lazaro de [UNIFESP] Carvalho, Antonio Carlos [UNIFESP] Tucci, Paulo José Ferreira [UNIFESP] |
dc.subject.eng.fl_str_mv |
myocardial infarct rat hearts Doppler echocardiogram |
topic |
myocardial infarct rat hearts Doppler echocardiogram |
description |
OBJECTIVE: To assess by Doppler echocardiography the structural and functional alterations of rat heart with surgical induced extensive myocardial infarction. METHODS: Five weeks after surgical ligature of the left coronary artery, 38 Wistar-EPM rats of both sexes, 10 of them with extensive infarction, undergone anatomical and functional evaluation by Doppler echocardiography and then euthanized for anatomopathological analysis. RESULTS: Echocardiography was 100% sensible and specific to anatomopathological confirmed extensive miocardial infarction. Extensive infarction lead to dilatation of left ventricle (diastolic diameter: 0.89cm vs.0.64cm; systolic: 0.72cm vs. 0.33cm) and left atrium (0.55cm vs. 0.33cm); thinning of left ventricular anterior wall (systolic: 0.14cm vs. 0.23cm, diastolic: 0.11cm vs. 0.14cm); increased mitral E/ A wave relation (6.45 vs. 1.95). Signals of increased end diastolic ventricle pressure, B point in mitral valve tracing in 62.5% and signs of pulmonary hypertension straightening of pulmonary valve (90%) and notching of pulmonary systolic flow (60%) were observed in animals with extensive infarction. CONCLUSION: Doppler echocardiography has a high sensitivity and specificity for detection of chronic extensive infarction. Extensive infarction caused dilatation of left cardiac chambers and showed in Doppler signals of increased end diastolic left ventricular pressure and pulmonary artery pressure. |
publishDate |
2000 |
dc.date.issued.fl_str_mv |
2000-08-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:25:06Z |
dc.date.available.fl_str_mv |
2015-06-14T13:25:06Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 75, n. 2, p. 131-136, 2000. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/1011 http://dx.doi.org/10.1590/S0066-782X2000000800005 |
dc.identifier.issn.none.fl_str_mv |
0066-782X |
dc.identifier.file.none.fl_str_mv |
S0066-782X2000000800005.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0066-782X2000000800005 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0066-782X2000000800005 |
identifier_str_mv |
Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 75, n. 2, p. 131-136, 2000. 0066-782X S0066-782X2000000800005.pdf S0066-782X2000000800005 10.1590/S0066-782X2000000800005 |
url |
http://repositorio.unifesp.br/handle/11600/1011 http://dx.doi.org/10.1590/S0066-782X2000000800005 |
dc.language.iso.fl_str_mv |
eng |
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Arquivos Brasileiros de Cardiologia |
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info:eu-repo/semantics/openAccess |
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openAccess |
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131-136 |
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Sociedade Brasileira de Cardiologia - SBC |
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Sociedade Brasileira de Cardiologia - SBC |
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