Effects of the M1 Muscarinic Antagonist Dicyclomine on Emotional Memory Retrieval
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/58600 https://doi.org/10.1037/bne0000113 |
Resumo: | Extensive research has shown the involvement of the central cholinergic system in the acquisition and consolidation of tasks involving conditioned fear responses, such as those observed in contextual fear conditioning (CFC), tone fear conditioning (TFC) and inhibitory avoidance (IA). However, there are few data concerning the role of this system in the memory retrieval process. Therefore, the present study aimed to compare the effects of the administration of an M1 antagonist on retrieval during these tasks. For each behavioral procedure, groups of male Wistar rats were trained. Twenty-four hr later, they were treated with different doses of dicyclomine (16, 32, or 64 mg/kg, i.p.) or with saline 30 min before the test session. The results showed that dicyclomine at doses of 16 and 32 mg/kg impaired CFC without interfering with IA performance. Moreover, only 64 mg/kg impaired TFC. These data suggest that M1 muscarinic receptors contribute to memory retrieval in CFC and TFC but are not essential for retrieval in IA. |
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Soares, Juliana Carlota Kramer [UNIFESP]Perfetto, Juliano Genaro [UNIFESP]Antonio, Bruno Brito [UNIFESP]Oliveira, Maria Gabriela Menezes [UNIFESP]2020-11-03T14:40:31Z2020-11-03T14:40:31Z2016Behavioral Neuroscience. Washington, v. 130, n. 1, p. 29-35, 2016.0735-7044https://repositorio.unifesp.br/handle/11600/58600https://doi.org/10.1037/bne000011310.1037/bne0000113WOS:000370745000004Extensive research has shown the involvement of the central cholinergic system in the acquisition and consolidation of tasks involving conditioned fear responses, such as those observed in contextual fear conditioning (CFC), tone fear conditioning (TFC) and inhibitory avoidance (IA). However, there are few data concerning the role of this system in the memory retrieval process. Therefore, the present study aimed to compare the effects of the administration of an M1 antagonist on retrieval during these tasks. For each behavioral procedure, groups of male Wistar rats were trained. Twenty-four hr later, they were treated with different doses of dicyclomine (16, 32, or 64 mg/kg, i.p.) or with saline 30 min before the test session. The results showed that dicyclomine at doses of 16 and 32 mg/kg impaired CFC without interfering with IA performance. Moreover, only 64 mg/kg impaired TFC. These data suggest that M1 muscarinic receptors contribute to memory retrieval in CFC and TFC but are not essential for retrieval in IA.Coordination for the Improvement of Higher Education Personnel (CAPES)National Council of Scientific and Technological Development (CNPq)Research Incentive Fund Association (AFIP)Sao Paulo Research Foundation (FAPESP)Univ Fed Sao Paulo, Dept Psychobiol, UNIFESP, Rua Botucatu 862,Edificio Ciencias Biomed 1 Andar, BR-04023062 Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Psychobiol, UNIFESP, Rua Botucatu 862,Edificio Ciencias Biomed 1 Andar, BR-04023062 Sao Paulo, BrazilWeb of Science29-35engAmer Psychological AssocBehavioral Neurosciencefear conditioninginhibitory avoidancememory retrievalcholinergicdicyclomineEffects of the M1 Muscarinic Antagonist Dicyclomine on Emotional Memory Retrievalinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleWashington1301info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/586002021-10-05 21:33:38.346metadata only accessoai:repositorio.unifesp.br:11600/58600Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652021-10-06T00:33:38Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Effects of the M1 Muscarinic Antagonist Dicyclomine on Emotional Memory Retrieval |
title |
Effects of the M1 Muscarinic Antagonist Dicyclomine on Emotional Memory Retrieval |
spellingShingle |
Effects of the M1 Muscarinic Antagonist Dicyclomine on Emotional Memory Retrieval Soares, Juliana Carlota Kramer [UNIFESP] fear conditioning inhibitory avoidance memory retrieval cholinergic dicyclomine |
title_short |
Effects of the M1 Muscarinic Antagonist Dicyclomine on Emotional Memory Retrieval |
title_full |
Effects of the M1 Muscarinic Antagonist Dicyclomine on Emotional Memory Retrieval |
title_fullStr |
Effects of the M1 Muscarinic Antagonist Dicyclomine on Emotional Memory Retrieval |
title_full_unstemmed |
Effects of the M1 Muscarinic Antagonist Dicyclomine on Emotional Memory Retrieval |
title_sort |
Effects of the M1 Muscarinic Antagonist Dicyclomine on Emotional Memory Retrieval |
author |
Soares, Juliana Carlota Kramer [UNIFESP] |
author_facet |
Soares, Juliana Carlota Kramer [UNIFESP] Perfetto, Juliano Genaro [UNIFESP] Antonio, Bruno Brito [UNIFESP] Oliveira, Maria Gabriela Menezes [UNIFESP] |
author_role |
author |
author2 |
Perfetto, Juliano Genaro [UNIFESP] Antonio, Bruno Brito [UNIFESP] Oliveira, Maria Gabriela Menezes [UNIFESP] |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Soares, Juliana Carlota Kramer [UNIFESP] Perfetto, Juliano Genaro [UNIFESP] Antonio, Bruno Brito [UNIFESP] Oliveira, Maria Gabriela Menezes [UNIFESP] |
dc.subject.eng.fl_str_mv |
fear conditioning inhibitory avoidance memory retrieval cholinergic dicyclomine |
topic |
fear conditioning inhibitory avoidance memory retrieval cholinergic dicyclomine |
description |
Extensive research has shown the involvement of the central cholinergic system in the acquisition and consolidation of tasks involving conditioned fear responses, such as those observed in contextual fear conditioning (CFC), tone fear conditioning (TFC) and inhibitory avoidance (IA). However, there are few data concerning the role of this system in the memory retrieval process. Therefore, the present study aimed to compare the effects of the administration of an M1 antagonist on retrieval during these tasks. For each behavioral procedure, groups of male Wistar rats were trained. Twenty-four hr later, they were treated with different doses of dicyclomine (16, 32, or 64 mg/kg, i.p.) or with saline 30 min before the test session. The results showed that dicyclomine at doses of 16 and 32 mg/kg impaired CFC without interfering with IA performance. Moreover, only 64 mg/kg impaired TFC. These data suggest that M1 muscarinic receptors contribute to memory retrieval in CFC and TFC but are not essential for retrieval in IA. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2020-11-03T14:40:31Z |
dc.date.available.fl_str_mv |
2020-11-03T14:40:31Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Behavioral Neuroscience. Washington, v. 130, n. 1, p. 29-35, 2016. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/58600 https://doi.org/10.1037/bne0000113 |
dc.identifier.issn.none.fl_str_mv |
0735-7044 |
dc.identifier.doi.none.fl_str_mv |
10.1037/bne0000113 |
dc.identifier.wos.none.fl_str_mv |
WOS:000370745000004 |
identifier_str_mv |
Behavioral Neuroscience. Washington, v. 130, n. 1, p. 29-35, 2016. 0735-7044 10.1037/bne0000113 WOS:000370745000004 |
url |
https://repositorio.unifesp.br/handle/11600/58600 https://doi.org/10.1037/bne0000113 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Behavioral Neuroscience |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
29-35 |
dc.coverage.none.fl_str_mv |
Washington |
dc.publisher.none.fl_str_mv |
Amer Psychological Assoc |
publisher.none.fl_str_mv |
Amer Psychological Assoc |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764115651854336 |