ROLE OF THE ROSTRAL VENTROLATERAL MEDULLA IN MAINTENANCE OF BLOOD-PRESSURE IN RATS WITH GOLDBLATT HYPERTENSION
Autor(a) principal: | |
---|---|
Data de Publicação: | 1995 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/11600/43824 https://doi.org/10.1161/01.HYP.26.6.1117 |
Resumo: | The aim of the present study was to examine the participation of the rostral ventrolateral medulla (RVLM) in the maintenance of hypertension in rats submitted to the renovascular Goldblatt (two-kidney, one clip) procedure. We inhibited or stimulated this area with the use of drugs such as glycine, L-glutamate, or kynurenic acid. (1) Bilateral microinjection of glycine (100 nmol, 200 nL, n=13) into the RVLM of hypertensive rats produced a decrease in mean arterial blood pressure (MAP) from 177.2+/-29.3 to 102.3+/-20.9 mm Hg (P<.05), which was similar to the decrease produced by intravenous administration of hexamethonium. The inhibition of RVLM with glycine in normotensive rats produced a decrease in MAP from 106+/-17.1 to 59.7+/-7.3 mm Hg (P<.05, n=9). (2) An impressive increase in MAP from 153.3+/-16.3 to 228+/-34.9 mm Hg (P<.05) occurred in hypertensive rats after microinjection of L-glutamate (50 nmol, 200 nL, n=6) into the RVLM. The same procedure caused a significant but less intense increase in MAP from 105+/-13.8 to 148.3+/-24.9 mm Hg in normotensive rats (P<.05, n=6). (3) A decrease in MAP from 151.6+/-25.3 to 96.8+/-22.5 mm Hg occurred in hypertensive rats after microinjection of the broad-spectrum glutamate antagonist kynurenic acid (4 nmol, 200 nL, n=6) into the RVLM, whereas the same procedure did not change MAP in normotensive animals (n=6). Heart rate was not significantly affected in any group. Together these results show that the activity of RVLM neurons is important in the maintenance of arterial blood pressure in Goldblatt hypertensive rats and probably indicate a change in the sensitivity and/or number of glutamatergic receptors in this area after the development of hypertension. |
id |
UFSP_dd9125580ece408f2e2b0921f8ce2ed3 |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br:11600/43824 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Bergamaschi, Cassia Toledo [UNIFESP]Campos, Ruy Ribeiro [UNIFESP]Schor, Nestor [UNIFESP]Lopes, Oswaldo Ubriaco [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2018-06-15T17:35:12Z2018-06-15T17:35:12Z1995-12-01Hypertension. Dallas: Amer Heart Assoc, v. 26, n. 6, p. 1117-1120, 1995.0194-911Xhttp://repositorio.unifesp.br/11600/43824https://doi.org/10.1161/01.HYP.26.6.111710.1161/01.HYP.26.6.1117WOS:A1995TK02300021The aim of the present study was to examine the participation of the rostral ventrolateral medulla (RVLM) in the maintenance of hypertension in rats submitted to the renovascular Goldblatt (two-kidney, one clip) procedure. We inhibited or stimulated this area with the use of drugs such as glycine, L-glutamate, or kynurenic acid. (1) Bilateral microinjection of glycine (100 nmol, 200 nL, n=13) into the RVLM of hypertensive rats produced a decrease in mean arterial blood pressure (MAP) from 177.2+/-29.3 to 102.3+/-20.9 mm Hg (P<.05), which was similar to the decrease produced by intravenous administration of hexamethonium. The inhibition of RVLM with glycine in normotensive rats produced a decrease in MAP from 106+/-17.1 to 59.7+/-7.3 mm Hg (P<.05, n=9). (2) An impressive increase in MAP from 153.3+/-16.3 to 228+/-34.9 mm Hg (P<.05) occurred in hypertensive rats after microinjection of L-glutamate (50 nmol, 200 nL, n=6) into the RVLM. The same procedure caused a significant but less intense increase in MAP from 105+/-13.8 to 148.3+/-24.9 mm Hg in normotensive rats (P<.05, n=6). (3) A decrease in MAP from 151.6+/-25.3 to 96.8+/-22.5 mm Hg occurred in hypertensive rats after microinjection of the broad-spectrum glutamate antagonist kynurenic acid (4 nmol, 200 nL, n=6) into the RVLM, whereas the same procedure did not change MAP in normotensive animals (n=6). Heart rate was not significantly affected in any group. Together these results show that the activity of RVLM neurons is important in the maintenance of arterial blood pressure in Goldblatt hypertensive rats and probably indicate a change in the sensitivity and/or number of glutamatergic receptors in this area after the development of hypertension.UNIV FED SAO PAULO,ESCOLA PAULISTA MED,DEPT FISIOL,BR-04023060 SAO PAULO,BRAZILUNIV FED SAO PAULO,ESCOLA PAULISTA MED,DIV NEPHROL,BR-04023060 SAO PAULO,BRAZILUNIV FED SAO PAULO,ESCOLA PAULISTA MED,DEPT FISIOL,BR-04023060 SAO PAULO,BRAZILUNIV FED SAO PAULO,ESCOLA PAULISTA MED,DIV NEPHROL,BR-04023060 SAO PAULO,BRAZILWeb of Science1117-1120engAmer Heart AssocHypertensionRATSBLOOD PRESSURE, ARTERIALBRAINGOLDBLATT MODELHEART RATEROLE OF THE ROSTRAL VENTROLATERAL MEDULLA IN MAINTENANCE OF BLOOD-PRESSURE IN RATS WITH GOLDBLATT HYPERTENSIONinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/438242021-09-30 17:28:01.913metadata only accessoai:repositorio.unifesp.br:11600/43824Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:19:09.702469Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
ROLE OF THE ROSTRAL VENTROLATERAL MEDULLA IN MAINTENANCE OF BLOOD-PRESSURE IN RATS WITH GOLDBLATT HYPERTENSION |
title |
ROLE OF THE ROSTRAL VENTROLATERAL MEDULLA IN MAINTENANCE OF BLOOD-PRESSURE IN RATS WITH GOLDBLATT HYPERTENSION |
spellingShingle |
ROLE OF THE ROSTRAL VENTROLATERAL MEDULLA IN MAINTENANCE OF BLOOD-PRESSURE IN RATS WITH GOLDBLATT HYPERTENSION Bergamaschi, Cassia Toledo [UNIFESP] RATS BLOOD PRESSURE, ARTERIAL BRAIN GOLDBLATT MODEL HEART RATE |
title_short |
ROLE OF THE ROSTRAL VENTROLATERAL MEDULLA IN MAINTENANCE OF BLOOD-PRESSURE IN RATS WITH GOLDBLATT HYPERTENSION |
title_full |
ROLE OF THE ROSTRAL VENTROLATERAL MEDULLA IN MAINTENANCE OF BLOOD-PRESSURE IN RATS WITH GOLDBLATT HYPERTENSION |
title_fullStr |
ROLE OF THE ROSTRAL VENTROLATERAL MEDULLA IN MAINTENANCE OF BLOOD-PRESSURE IN RATS WITH GOLDBLATT HYPERTENSION |
title_full_unstemmed |
ROLE OF THE ROSTRAL VENTROLATERAL MEDULLA IN MAINTENANCE OF BLOOD-PRESSURE IN RATS WITH GOLDBLATT HYPERTENSION |
title_sort |
ROLE OF THE ROSTRAL VENTROLATERAL MEDULLA IN MAINTENANCE OF BLOOD-PRESSURE IN RATS WITH GOLDBLATT HYPERTENSION |
author |
Bergamaschi, Cassia Toledo [UNIFESP] |
author_facet |
Bergamaschi, Cassia Toledo [UNIFESP] Campos, Ruy Ribeiro [UNIFESP] Schor, Nestor [UNIFESP] Lopes, Oswaldo Ubriaco [UNIFESP] |
author_role |
author |
author2 |
Campos, Ruy Ribeiro [UNIFESP] Schor, Nestor [UNIFESP] Lopes, Oswaldo Ubriaco [UNIFESP] |
author2_role |
author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Bergamaschi, Cassia Toledo [UNIFESP] Campos, Ruy Ribeiro [UNIFESP] Schor, Nestor [UNIFESP] Lopes, Oswaldo Ubriaco [UNIFESP] |
dc.subject.eng.fl_str_mv |
RATS BLOOD PRESSURE, ARTERIAL BRAIN GOLDBLATT MODEL HEART RATE |
topic |
RATS BLOOD PRESSURE, ARTERIAL BRAIN GOLDBLATT MODEL HEART RATE |
description |
The aim of the present study was to examine the participation of the rostral ventrolateral medulla (RVLM) in the maintenance of hypertension in rats submitted to the renovascular Goldblatt (two-kidney, one clip) procedure. We inhibited or stimulated this area with the use of drugs such as glycine, L-glutamate, or kynurenic acid. (1) Bilateral microinjection of glycine (100 nmol, 200 nL, n=13) into the RVLM of hypertensive rats produced a decrease in mean arterial blood pressure (MAP) from 177.2+/-29.3 to 102.3+/-20.9 mm Hg (P<.05), which was similar to the decrease produced by intravenous administration of hexamethonium. The inhibition of RVLM with glycine in normotensive rats produced a decrease in MAP from 106+/-17.1 to 59.7+/-7.3 mm Hg (P<.05, n=9). (2) An impressive increase in MAP from 153.3+/-16.3 to 228+/-34.9 mm Hg (P<.05) occurred in hypertensive rats after microinjection of L-glutamate (50 nmol, 200 nL, n=6) into the RVLM. The same procedure caused a significant but less intense increase in MAP from 105+/-13.8 to 148.3+/-24.9 mm Hg in normotensive rats (P<.05, n=6). (3) A decrease in MAP from 151.6+/-25.3 to 96.8+/-22.5 mm Hg occurred in hypertensive rats after microinjection of the broad-spectrum glutamate antagonist kynurenic acid (4 nmol, 200 nL, n=6) into the RVLM, whereas the same procedure did not change MAP in normotensive animals (n=6). Heart rate was not significantly affected in any group. Together these results show that the activity of RVLM neurons is important in the maintenance of arterial blood pressure in Goldblatt hypertensive rats and probably indicate a change in the sensitivity and/or number of glutamatergic receptors in this area after the development of hypertension. |
publishDate |
1995 |
dc.date.issued.fl_str_mv |
1995-12-01 |
dc.date.accessioned.fl_str_mv |
2018-06-15T17:35:12Z |
dc.date.available.fl_str_mv |
2018-06-15T17:35:12Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Hypertension. Dallas: Amer Heart Assoc, v. 26, n. 6, p. 1117-1120, 1995. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/11600/43824 https://doi.org/10.1161/01.HYP.26.6.1117 |
dc.identifier.issn.none.fl_str_mv |
0194-911X |
dc.identifier.doi.none.fl_str_mv |
10.1161/01.HYP.26.6.1117 |
dc.identifier.wos.none.fl_str_mv |
WOS:A1995TK02300021 |
identifier_str_mv |
Hypertension. Dallas: Amer Heart Assoc, v. 26, n. 6, p. 1117-1120, 1995. 0194-911X 10.1161/01.HYP.26.6.1117 WOS:A1995TK02300021 |
url |
http://repositorio.unifesp.br/11600/43824 https://doi.org/10.1161/01.HYP.26.6.1117 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Hypertension |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1117-1120 |
dc.publisher.none.fl_str_mv |
Amer Heart Assoc |
publisher.none.fl_str_mv |
Amer Heart Assoc |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1783460275990560768 |