Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling

Detalhes bibliográficos
Autor(a) principal: Pezato, Rogerio [UNIFESP]
Data de Publicação: 2013
Outros Autores: Balsalobre, Leonardo [UNIFESP], Lima, Milena, Bezerra, Thiago F. P., Voegels, Richard L., Gregório, Luis Carlos [UNIFESP], Stamm, Aldo Cassol [UNIFESP], van Zele, Thibaut
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
dARK ID: ark:/48912/001300000tg8v
Texto Completo: http://dx.doi.org/10.1186/1916-0216-42-27
http://repositorio.unifesp.br/handle/11600/36104
Resumo: This review is addressed two pathophysiologic mechanisms implicated in the pathogenesis of nasal polyposis: the unique remodeling process found in nasal polyp tissue and the immune response of patients with nasal polyposis to Staphylococcus aureus.These two theories converge to the same direction in different aspects, including decreased extracellular matrix production, impaired T regulation and favoring of a Th2 immune response.In patients with nasal polyposis, an exaggerated immune response to Staphylococcus aureus may aggravate the airway remodeling process.
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spelling Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodelingAirway remodelingSuperantigensNasal polypsThis review is addressed two pathophysiologic mechanisms implicated in the pathogenesis of nasal polyposis: the unique remodeling process found in nasal polyp tissue and the immune response of patients with nasal polyposis to Staphylococcus aureus.These two theories converge to the same direction in different aspects, including decreased extracellular matrix production, impaired T regulation and favoring of a Th2 immune response.In patients with nasal polyposis, an exaggerated immune response to Staphylococcus aureus may aggravate the airway remodeling process.Universidade Federal de São Paulo, Dept Otolaryngol Head & Neck Surg, BR-02526060 São Paulo, BrazilUniv Ghent, Dept Otorhinolaryngol, Ghent Univ Hosp, B-9000 Ghent, BelgiumMil Police Hosp, São Paulo, BrazilUniv São Paulo, Dept Otorhinolaryngol & Ophthalmol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Otolaryngol Head & Neck Surg, BR-02526060 São Paulo, BrazilWeb of ScienceBiomed Central LtdUniversidade Federal de São Paulo (UNIFESP)Univ GhentMil Police HospUniversidade de São Paulo (USP)Pezato, Rogerio [UNIFESP]Balsalobre, Leonardo [UNIFESP]Lima, MilenaBezerra, Thiago F. P.Voegels, Richard L.Gregório, Luis Carlos [UNIFESP]Stamm, Aldo Cassol [UNIFESP]van Zele, Thibaut2016-01-24T14:31:27Z2016-01-24T14:31:27Z2013-03-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion5application/pdfhttp://dx.doi.org/10.1186/1916-0216-42-27Journal of Otolaryngology-head & Neck Surgery. London: Biomed Central Ltd, v. 42, 5 p., 2013.10.1186/1916-0216-42-27WOS000318410000002.pdf1916-0216http://repositorio.unifesp.br/handle/11600/36104WOS:000318410000002ark:/48912/001300000tg8vengJournal of Otolaryngology-head & Neck Surgeryinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-28T19:20:23Zoai:repositorio.unifesp.br/:11600/36104Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:37:23.671158Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling
title Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling
spellingShingle Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling
Pezato, Rogerio [UNIFESP]
Airway remodeling
Superantigens
Nasal polyps
title_short Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling
title_full Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling
title_fullStr Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling
title_full_unstemmed Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling
title_sort Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling
author Pezato, Rogerio [UNIFESP]
author_facet Pezato, Rogerio [UNIFESP]
Balsalobre, Leonardo [UNIFESP]
Lima, Milena
Bezerra, Thiago F. P.
Voegels, Richard L.
Gregório, Luis Carlos [UNIFESP]
Stamm, Aldo Cassol [UNIFESP]
van Zele, Thibaut
author_role author
author2 Balsalobre, Leonardo [UNIFESP]
Lima, Milena
Bezerra, Thiago F. P.
Voegels, Richard L.
Gregório, Luis Carlos [UNIFESP]
Stamm, Aldo Cassol [UNIFESP]
van Zele, Thibaut
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Univ Ghent
Mil Police Hosp
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Pezato, Rogerio [UNIFESP]
Balsalobre, Leonardo [UNIFESP]
Lima, Milena
Bezerra, Thiago F. P.
Voegels, Richard L.
Gregório, Luis Carlos [UNIFESP]
Stamm, Aldo Cassol [UNIFESP]
van Zele, Thibaut
dc.subject.por.fl_str_mv Airway remodeling
Superantigens
Nasal polyps
topic Airway remodeling
Superantigens
Nasal polyps
description This review is addressed two pathophysiologic mechanisms implicated in the pathogenesis of nasal polyposis: the unique remodeling process found in nasal polyp tissue and the immune response of patients with nasal polyposis to Staphylococcus aureus.These two theories converge to the same direction in different aspects, including decreased extracellular matrix production, impaired T regulation and favoring of a Th2 immune response.In patients with nasal polyposis, an exaggerated immune response to Staphylococcus aureus may aggravate the airway remodeling process.
publishDate 2013
dc.date.none.fl_str_mv 2013-03-28
2016-01-24T14:31:27Z
2016-01-24T14:31:27Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1186/1916-0216-42-27
Journal of Otolaryngology-head & Neck Surgery. London: Biomed Central Ltd, v. 42, 5 p., 2013.
10.1186/1916-0216-42-27
WOS000318410000002.pdf
1916-0216
http://repositorio.unifesp.br/handle/11600/36104
WOS:000318410000002
dc.identifier.dark.fl_str_mv ark:/48912/001300000tg8v
url http://dx.doi.org/10.1186/1916-0216-42-27
http://repositorio.unifesp.br/handle/11600/36104
identifier_str_mv Journal of Otolaryngology-head & Neck Surgery. London: Biomed Central Ltd, v. 42, 5 p., 2013.
10.1186/1916-0216-42-27
WOS000318410000002.pdf
1916-0216
WOS:000318410000002
ark:/48912/001300000tg8v
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Otolaryngology-head & Neck Surgery
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 5
application/pdf
dc.publisher.none.fl_str_mv Biomed Central Ltd
publisher.none.fl_str_mv Biomed Central Ltd
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1818602517193293824

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