Endovascular model of abdominal aortic aneurysm induction in swine
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/37803 http://dx.doi.org/10.1177/1358863X14534006 |
Resumo: | Abdominal aortic aneurysms are among the main causes of death. the high morbidity and mortality associated with aneurysm rupture and repair represents a challenge for surgeons and high risk for patients. Although experimental models are useful to understand, train, and develop new treatment and diagnostic methods for this pathology, animal models developed to date are far from ideal. Animals are either too small and do not represent the pathology of humans, or the procedures employ laparotomy, or the aortic behavior does not resemble that of a true aneurysm. We developed a novel, less invasive and effective method to induce true aortic aneurysms in Large White pigs. Animals were submitted to an endovascular chemical induction using either calcium chloride (25%) or swine pancreatic elastase. Controls were exposed to saline solution. All animals were operated on using the same surgical technique under general anesthesia. They were followed weekly with ultrasound examinations and at 4 weeks the aorta was harvested. Although elastase induced only arterial dilation, imaging, histological, and biomechanical studies of the aorta revealed the formation of true aneurysms in animals exposed to calcium chloride. Aneurysms in the latter group had biomechanical failure properties similar to those of human aneurysms. These findings indicate that the endovascular approach is viable and does not cause retroperitoneal fibrosis. |
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Lederman, AlexSaliture Neto, Fernando TavaresFerreira, Rimarcs [UNIFESP]Figueiredo, Luis Francisco Poli deOtoch, Jose PinhataAun, RicardoSilva, Erasmo Simao daUniversidade de São Paulo (USP)Hosp Israelita Albert EinsteinUniversidade Federal de São Paulo (UNIFESP)2016-01-24T14:37:20Z2016-01-24T14:37:20Z2014-06-01Vascular Medicine. London: Sage Publications Ltd, v. 19, n. 3, p. 167-174, 2014.1358-863Xhttp://repositorio.unifesp.br/handle/11600/37803http://dx.doi.org/10.1177/1358863X1453400610.1177/1358863X14534006WOS:000337579800002Abdominal aortic aneurysms are among the main causes of death. the high morbidity and mortality associated with aneurysm rupture and repair represents a challenge for surgeons and high risk for patients. Although experimental models are useful to understand, train, and develop new treatment and diagnostic methods for this pathology, animal models developed to date are far from ideal. Animals are either too small and do not represent the pathology of humans, or the procedures employ laparotomy, or the aortic behavior does not resemble that of a true aneurysm. We developed a novel, less invasive and effective method to induce true aortic aneurysms in Large White pigs. Animals were submitted to an endovascular chemical induction using either calcium chloride (25%) or swine pancreatic elastase. Controls were exposed to saline solution. All animals were operated on using the same surgical technique under general anesthesia. They were followed weekly with ultrasound examinations and at 4 weeks the aorta was harvested. Although elastase induced only arterial dilation, imaging, histological, and biomechanical studies of the aorta revealed the formation of true aneurysms in animals exposed to calcium chloride. Aneurysms in the latter group had biomechanical failure properties similar to those of human aneurysms. These findings indicate that the endovascular approach is viable and does not cause retroperitoneal fibrosis.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ São Paulo, Univ Hosp, São Paulo, BrazilHosp Israelita Albert Einstein, São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, São Paulo, BrazilUniv São Paulo, Fac Med, São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, São Paulo, BrazilFAPESP: 2010/07307-6Web of Science167-174engSage Publications LtdVascular Medicinehttp://www.uk.sagepub.com/aboutus/openaccess.htminfo:eu-repo/semantics/openAccessaortic aneurysmbiomechanicscalcium chlorideelastasepig modelEndovascular model of abdominal aortic aneurysm induction in swineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/378032022-06-02 09:02:17.392metadata only accessoai:repositorio.unifesp.br:11600/37803Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-06-02T12:02:17Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Endovascular model of abdominal aortic aneurysm induction in swine |
title |
Endovascular model of abdominal aortic aneurysm induction in swine |
spellingShingle |
Endovascular model of abdominal aortic aneurysm induction in swine Lederman, Alex aortic aneurysm biomechanics calcium chloride elastase pig model |
title_short |
Endovascular model of abdominal aortic aneurysm induction in swine |
title_full |
Endovascular model of abdominal aortic aneurysm induction in swine |
title_fullStr |
Endovascular model of abdominal aortic aneurysm induction in swine |
title_full_unstemmed |
Endovascular model of abdominal aortic aneurysm induction in swine |
title_sort |
Endovascular model of abdominal aortic aneurysm induction in swine |
author |
Lederman, Alex |
author_facet |
Lederman, Alex Saliture Neto, Fernando Tavares Ferreira, Rimarcs [UNIFESP] Figueiredo, Luis Francisco Poli de Otoch, Jose Pinhata Aun, Ricardo Silva, Erasmo Simao da |
author_role |
author |
author2 |
Saliture Neto, Fernando Tavares Ferreira, Rimarcs [UNIFESP] Figueiredo, Luis Francisco Poli de Otoch, Jose Pinhata Aun, Ricardo Silva, Erasmo Simao da |
author2_role |
author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade de São Paulo (USP) Hosp Israelita Albert Einstein Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Lederman, Alex Saliture Neto, Fernando Tavares Ferreira, Rimarcs [UNIFESP] Figueiredo, Luis Francisco Poli de Otoch, Jose Pinhata Aun, Ricardo Silva, Erasmo Simao da |
dc.subject.eng.fl_str_mv |
aortic aneurysm biomechanics calcium chloride elastase pig model |
topic |
aortic aneurysm biomechanics calcium chloride elastase pig model |
description |
Abdominal aortic aneurysms are among the main causes of death. the high morbidity and mortality associated with aneurysm rupture and repair represents a challenge for surgeons and high risk for patients. Although experimental models are useful to understand, train, and develop new treatment and diagnostic methods for this pathology, animal models developed to date are far from ideal. Animals are either too small and do not represent the pathology of humans, or the procedures employ laparotomy, or the aortic behavior does not resemble that of a true aneurysm. We developed a novel, less invasive and effective method to induce true aortic aneurysms in Large White pigs. Animals were submitted to an endovascular chemical induction using either calcium chloride (25%) or swine pancreatic elastase. Controls were exposed to saline solution. All animals were operated on using the same surgical technique under general anesthesia. They were followed weekly with ultrasound examinations and at 4 weeks the aorta was harvested. Although elastase induced only arterial dilation, imaging, histological, and biomechanical studies of the aorta revealed the formation of true aneurysms in animals exposed to calcium chloride. Aneurysms in the latter group had biomechanical failure properties similar to those of human aneurysms. These findings indicate that the endovascular approach is viable and does not cause retroperitoneal fibrosis. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-06-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:37:20Z |
dc.date.available.fl_str_mv |
2016-01-24T14:37:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Vascular Medicine. London: Sage Publications Ltd, v. 19, n. 3, p. 167-174, 2014. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/37803 http://dx.doi.org/10.1177/1358863X14534006 |
dc.identifier.issn.none.fl_str_mv |
1358-863X |
dc.identifier.doi.none.fl_str_mv |
10.1177/1358863X14534006 |
dc.identifier.wos.none.fl_str_mv |
WOS:000337579800002 |
identifier_str_mv |
Vascular Medicine. London: Sage Publications Ltd, v. 19, n. 3, p. 167-174, 2014. 1358-863X 10.1177/1358863X14534006 WOS:000337579800002 |
url |
http://repositorio.unifesp.br/handle/11600/37803 http://dx.doi.org/10.1177/1358863X14534006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Vascular Medicine |
dc.rights.driver.fl_str_mv |
http://www.uk.sagepub.com/aboutus/openaccess.htm info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://www.uk.sagepub.com/aboutus/openaccess.htm |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
167-174 |
dc.publisher.none.fl_str_mv |
Sage Publications Ltd |
publisher.none.fl_str_mv |
Sage Publications Ltd |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764128367935488 |