Antihypertensive efficacy of amlodipine and losartan after two 'missed' doses in patients with mild to moderate essential hypertension

• Autor(a) principal: Ribeiro, Artur Beltrame [UNIFESP]
• Data de Publicação: 2007
• Outros Autores: Mion Junior, Decio, Marin, M. J., Majul, Claudio, Botero, R., Lopez, N. R., Gonzalez, S., Izurieta, H., Francischetti, Emilio Antonio, Latin Amer Hypertension Study Grp
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: https://repositorio.unifesp.br/11600/44438; https://dx.doi.org/10.1177/147323000703500604
• topic: Amlodipine; Losartan; Antihypertensive drugs; Hypertension; Ambulatory blood pressure monitoring; Drug holiday; Therapeutic coverage

We compared the effects of amlodipine (5 - 10 mg, n = 94) and losartan (50 100 mg, n = 94) on the lowering of blood pressure (BP) at steady state and after two missed doses, as well as on tolerability. This was a randomized, double-blind study of 12 weeks of active treatment followed by 2 days of placebo treatment. Twenty-four-hour ambulatory blood pressure monitoring and office BP measurements were performed at baseline, week 12 and after the 2-day drug holiday. After 12 weeks, amlodipine was significantly more effective than losartan in reducing both 24-h systolic blood pressure (SBP) (-18.0 versus -10.8 mmHg) and diastolic blood pressure (DBP) (-10.6 versus -8.0 mmHg). While mean SBP and DBP for both treatments increased comparably during the drug holiday, BP values remained significantly lower than baseline for both treatments. The superior BP-lowering effect of amlodipine compared with losartan was maintained during the drug holiday.