Antihypertensive efficacy of amlodipine and losartan after two 'missed' doses in patients with mild to moderate essential hypertension
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/11600/44438 https://dx.doi.org/10.1177/147323000703500604 |
Resumo: | We compared the effects of amlodipine (5 - 10 mg, n = 94) and losartan (50 100 mg, n = 94) on the lowering of blood pressure (BP) at steady state and after two missed doses, as well as on tolerability. This was a randomized, double-blind study of 12 weeks of active treatment followed by 2 days of placebo treatment. Twenty-four-hour ambulatory blood pressure monitoring and office BP measurements were performed at baseline, week 12 and after the 2-day drug holiday. After 12 weeks, amlodipine was significantly more effective than losartan in reducing both 24-h systolic blood pressure (SBP) (-18.0 versus -10.8 mmHg) and diastolic blood pressure (DBP) (-10.6 versus -8.0 mmHg). While mean SBP and DBP for both treatments increased comparably during the drug holiday, BP values remained significantly lower than baseline for both treatments. The superior BP-lowering effect of amlodipine compared with losartan was maintained during the drug holiday. |
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Ribeiro, Artur Beltrame [UNIFESP]Mion Junior, DecioMarin, M. J.Majul, ClaudioBotero, R.Lopez, N. R.Gonzalez, S.Izurieta, H.Francischetti, Emilio AntonioLatin Amer Hypertension Study GrpUniversidade Federal de São Paulo (UNIFESP)Policlin BancarioHosp SantojanniClin MedellinCtr Med Docente La TrinidadGen Hosp DurangoCtr Med AlemaniaRio de Janeiro Sch MedUniversidade de São Paulo (USP)2018-06-15T18:02:33Z2018-06-15T18:02:33Z2007-11-01Journal Of International Medical Research. Worthing: Field House Publishing Llp, v. 35, n. 6, p. 762-772, 2007.0300-0605https://repositorio.unifesp.br/11600/44438https://dx.doi.org/10.1177/14732300070350060410.1177/147323000703500604WOS:000251382700004We compared the effects of amlodipine (5 - 10 mg, n = 94) and losartan (50 100 mg, n = 94) on the lowering of blood pressure (BP) at steady state and after two missed doses, as well as on tolerability. This was a randomized, double-blind study of 12 weeks of active treatment followed by 2 days of placebo treatment. Twenty-four-hour ambulatory blood pressure monitoring and office BP measurements were performed at baseline, week 12 and after the 2-day drug holiday. After 12 weeks, amlodipine was significantly more effective than losartan in reducing both 24-h systolic blood pressure (SBP) (-18.0 versus -10.8 mmHg) and diastolic blood pressure (DBP) (-10.6 versus -8.0 mmHg). While mean SBP and DBP for both treatments increased comparably during the drug holiday, BP values remained significantly lower than baseline for both treatments. The superior BP-lowering effect of amlodipine compared with losartan was maintained during the drug holiday.Hosp Rim & Hipertensao, Escola Paulista Med, Sao Paulo, BrazilPoliclin Bancario, Div Cardiol, Ctr Hipertens Arterial, Ciudad de Buenos Aires, ArgentinaHosp Santojanni, Serv Cardiol, Ciudad de Buenos Aires, ArgentinaClin Medellin, Medellin, ColombiaCtr Med Docente La Trinidad, Caracas, VenezuelaGen Hosp Durango, Durango, MexicoCtr Med Alemania, Quito, EcuadorRio de Janeiro Sch Med, Rio De Janeiro, BrazilUniv Sao Paulo, Sch Med, Sao Paulo, BrazilHosp Rim & Hipertensao, Escola Paulista Med, Sao Paulo, BrazilWeb of Science762-772engField House Publishing LlpJournal Of International Medical ResearchAmlodipineLosartanAntihypertensive drugsHypertensionAmbulatory blood pressure monitoringDrug holidayTherapeutic coverageAntihypertensive efficacy of amlodipine and losartan after two 'missed' doses in patients with mild to moderate essential hypertensioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/444382023-11-29 18:59:09.885metadata only accessoai:repositorio.unifesp.br:11600/44438Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-11-29T21:59:09Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Antihypertensive efficacy of amlodipine and losartan after two 'missed' doses in patients with mild to moderate essential hypertension |
title |
Antihypertensive efficacy of amlodipine and losartan after two 'missed' doses in patients with mild to moderate essential hypertension |
spellingShingle |
Antihypertensive efficacy of amlodipine and losartan after two 'missed' doses in patients with mild to moderate essential hypertension Ribeiro, Artur Beltrame [UNIFESP] Amlodipine Losartan Antihypertensive drugs Hypertension Ambulatory blood pressure monitoring Drug holiday Therapeutic coverage |
title_short |
Antihypertensive efficacy of amlodipine and losartan after two 'missed' doses in patients with mild to moderate essential hypertension |
title_full |
Antihypertensive efficacy of amlodipine and losartan after two 'missed' doses in patients with mild to moderate essential hypertension |
title_fullStr |
Antihypertensive efficacy of amlodipine and losartan after two 'missed' doses in patients with mild to moderate essential hypertension |
title_full_unstemmed |
Antihypertensive efficacy of amlodipine and losartan after two 'missed' doses in patients with mild to moderate essential hypertension |
title_sort |
Antihypertensive efficacy of amlodipine and losartan after two 'missed' doses in patients with mild to moderate essential hypertension |
author |
Ribeiro, Artur Beltrame [UNIFESP] |
author_facet |
Ribeiro, Artur Beltrame [UNIFESP] Mion Junior, Decio Marin, M. J. Majul, Claudio Botero, R. Lopez, N. R. Gonzalez, S. Izurieta, H. Francischetti, Emilio Antonio Latin Amer Hypertension Study Grp |
author_role |
author |
author2 |
Mion Junior, Decio Marin, M. J. Majul, Claudio Botero, R. Lopez, N. R. Gonzalez, S. Izurieta, H. Francischetti, Emilio Antonio Latin Amer Hypertension Study Grp |
author2_role |
author author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Policlin Bancario Hosp Santojanni Clin Medellin Ctr Med Docente La Trinidad Gen Hosp Durango Ctr Med Alemania Rio de Janeiro Sch Med Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Ribeiro, Artur Beltrame [UNIFESP] Mion Junior, Decio Marin, M. J. Majul, Claudio Botero, R. Lopez, N. R. Gonzalez, S. Izurieta, H. Francischetti, Emilio Antonio Latin Amer Hypertension Study Grp |
dc.subject.eng.fl_str_mv |
Amlodipine Losartan Antihypertensive drugs Hypertension Ambulatory blood pressure monitoring Drug holiday Therapeutic coverage |
topic |
Amlodipine Losartan Antihypertensive drugs Hypertension Ambulatory blood pressure monitoring Drug holiday Therapeutic coverage |
description |
We compared the effects of amlodipine (5 - 10 mg, n = 94) and losartan (50 100 mg, n = 94) on the lowering of blood pressure (BP) at steady state and after two missed doses, as well as on tolerability. This was a randomized, double-blind study of 12 weeks of active treatment followed by 2 days of placebo treatment. Twenty-four-hour ambulatory blood pressure monitoring and office BP measurements were performed at baseline, week 12 and after the 2-day drug holiday. After 12 weeks, amlodipine was significantly more effective than losartan in reducing both 24-h systolic blood pressure (SBP) (-18.0 versus -10.8 mmHg) and diastolic blood pressure (DBP) (-10.6 versus -8.0 mmHg). While mean SBP and DBP for both treatments increased comparably during the drug holiday, BP values remained significantly lower than baseline for both treatments. The superior BP-lowering effect of amlodipine compared with losartan was maintained during the drug holiday. |
publishDate |
2007 |
dc.date.issued.fl_str_mv |
2007-11-01 |
dc.date.accessioned.fl_str_mv |
2018-06-15T18:02:33Z |
dc.date.available.fl_str_mv |
2018-06-15T18:02:33Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Journal Of International Medical Research. Worthing: Field House Publishing Llp, v. 35, n. 6, p. 762-772, 2007. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/11600/44438 https://dx.doi.org/10.1177/147323000703500604 |
dc.identifier.issn.none.fl_str_mv |
0300-0605 |
dc.identifier.doi.none.fl_str_mv |
10.1177/147323000703500604 |
dc.identifier.wos.none.fl_str_mv |
WOS:000251382700004 |
identifier_str_mv |
Journal Of International Medical Research. Worthing: Field House Publishing Llp, v. 35, n. 6, p. 762-772, 2007. 0300-0605 10.1177/147323000703500604 WOS:000251382700004 |
url |
https://repositorio.unifesp.br/11600/44438 https://dx.doi.org/10.1177/147323000703500604 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Journal Of International Medical Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
762-772 |
dc.publisher.none.fl_str_mv |
Field House Publishing Llp |
publisher.none.fl_str_mv |
Field House Publishing Llp |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764245310373888 |