Effectiveness and Safety of Hypertonic Saline Inhalation Combined With Exercise Training in Patients With Chronic Obstructive Pulmonary Disease: A Randomized Trial

Detalhes bibliográficos
Autor(a) principal: Valderramas, Silvia Regina [UNIFESP]
Data de Publicação: 2009
Outros Autores: Atallah, Álvaro Nagib [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://rc.rcjournal.com/content/54/3/327
http://repositorio.unifesp.br/handle/11600/45210
Resumo: BACKGROUND: Inhaled hypertonic saline is used for bronchial challenge and sputum induction in patients with chronic obstructive pulmonary disease (COPD). We studied the effects of saline aerosol inhalation before each exercise session in an 8-week pulmonary rehabilitation program. METHODS: This was a double-blind randomized parallel controlled trial, conducted at an outpatient clinic. Sixty-eight subjects with COPD (mean age 67 +/- 6.5 y, percent of predicted FEV(1) 47 +/- 21) were randomized to inhale either 3% hypertonic saline (34 subjects) or normal saline (34 subjects) before each exercise session in an 8-week exercise program that had 3 sessions per week. We measured 6-min walk distance, dyspnea, and quality of life (with the Medical Outcomes Study 36-item short-form health survey). RESULTS: After the 8-week exercise program, both groups' mean 6-min walk distance had significantly increased: from 195 +/- 92 m to 251 +/- 97 m (P <.001) in the hypertonic-saline group, and from 237 +/- 93 m to 441 +/- 121 m in the normal-saline group (P <.001). The normal-saline group had greater improvement than the hypertonic-saline group (P <.001). Dyspnea score improved from 3.1 +/- 0.9 to 2.3 +/- 0.8 (P <.01) in the hypertonic-saline group, and from 3.5 +/- 0.2 to 2.3 +/- 1.0 (P <.01) in the normal-saline group. Quality of life also significantly improved, except for the physical-functioning and social aspect domains in the hypertonic-saline group. Adverse effects (cough or bronchospasm) occurred in 4 patients (12%) in the hypertonic-saline group. CONCLUSIONS: The improvement in 6-min walk distance was greater with normal saline than with hypertonic saline. Hypertonic saline was associated with adverse effects. It is unclear whether the only predictor of improved functional exercise capacity was exercise training.
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spelling Effectiveness and Safety of Hypertonic Saline Inhalation Combined With Exercise Training in Patients With Chronic Obstructive Pulmonary Disease: A Randomized Trialchronic obstructive pulmonary diseaseCOPDhypertonicsalineexercisesdyspneaBACKGROUND: Inhaled hypertonic saline is used for bronchial challenge and sputum induction in patients with chronic obstructive pulmonary disease (COPD). We studied the effects of saline aerosol inhalation before each exercise session in an 8-week pulmonary rehabilitation program. METHODS: This was a double-blind randomized parallel controlled trial, conducted at an outpatient clinic. Sixty-eight subjects with COPD (mean age 67 +/- 6.5 y, percent of predicted FEV(1) 47 +/- 21) were randomized to inhale either 3% hypertonic saline (34 subjects) or normal saline (34 subjects) before each exercise session in an 8-week exercise program that had 3 sessions per week. We measured 6-min walk distance, dyspnea, and quality of life (with the Medical Outcomes Study 36-item short-form health survey). RESULTS: After the 8-week exercise program, both groups' mean 6-min walk distance had significantly increased: from 195 +/- 92 m to 251 +/- 97 m (P <.001) in the hypertonic-saline group, and from 237 +/- 93 m to 441 +/- 121 m in the normal-saline group (P <.001). The normal-saline group had greater improvement than the hypertonic-saline group (P <.001). Dyspnea score improved from 3.1 +/- 0.9 to 2.3 +/- 0.8 (P <.01) in the hypertonic-saline group, and from 3.5 +/- 0.2 to 2.3 +/- 1.0 (P <.01) in the normal-saline group. Quality of life also significantly improved, except for the physical-functioning and social aspect domains in the hypertonic-saline group. Adverse effects (cough or bronchospasm) occurred in 4 patients (12%) in the hypertonic-saline group. CONCLUSIONS: The improvement in 6-min walk distance was greater with normal saline than with hypertonic saline. Hypertonic saline was associated with adverse effects. It is unclear whether the only predictor of improved functional exercise capacity was exercise training.Evangel Univ Parana, Dept Physiotherapy, Div Resp Rehabil, Curitiba, Parana, BrazilUniv Fed Sao Paulo, Escola Paulista Med, Dept Emergency Med, Sao Paulo, BrazilBrasilian Cochrane Ctr, Sao Paulo, BrazilUniv Fed Sao Paulo, Escola Paulista Med, Dept Emergency Med, Sao Paulo, BrazilWeb of ScienceDaedalus Enterprises IncEvangel Univ ParanaUniversidade Federal de São Paulo (UNIFESP)Brasilian Cochrane CtrValderramas, Silvia Regina [UNIFESP]Atallah, Álvaro Nagib [UNIFESP]2018-06-18T11:35:35Z2018-06-18T11:35:35Z2009-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion327-333http://rc.rcjournal.com/content/54/3/327Respiratory Care. Irving: Daedalus Enterprises Inc, v. 54, n. 3, p. 327-333, 2009.0020-1324http://repositorio.unifesp.br/handle/11600/45210WOS:000264112600005engRespiratory Careinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-05-02T15:52:34Zoai:repositorio.unifesp.br/:11600/45210Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-05-02T15:52:34Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Effectiveness and Safety of Hypertonic Saline Inhalation Combined With Exercise Training in Patients With Chronic Obstructive Pulmonary Disease: A Randomized Trial
title Effectiveness and Safety of Hypertonic Saline Inhalation Combined With Exercise Training in Patients With Chronic Obstructive Pulmonary Disease: A Randomized Trial
spellingShingle Effectiveness and Safety of Hypertonic Saline Inhalation Combined With Exercise Training in Patients With Chronic Obstructive Pulmonary Disease: A Randomized Trial
Valderramas, Silvia Regina [UNIFESP]
chronic obstructive pulmonary disease
COPD
hypertonic
saline
exercises
dyspnea
title_short Effectiveness and Safety of Hypertonic Saline Inhalation Combined With Exercise Training in Patients With Chronic Obstructive Pulmonary Disease: A Randomized Trial
title_full Effectiveness and Safety of Hypertonic Saline Inhalation Combined With Exercise Training in Patients With Chronic Obstructive Pulmonary Disease: A Randomized Trial
title_fullStr Effectiveness and Safety of Hypertonic Saline Inhalation Combined With Exercise Training in Patients With Chronic Obstructive Pulmonary Disease: A Randomized Trial
title_full_unstemmed Effectiveness and Safety of Hypertonic Saline Inhalation Combined With Exercise Training in Patients With Chronic Obstructive Pulmonary Disease: A Randomized Trial
title_sort Effectiveness and Safety of Hypertonic Saline Inhalation Combined With Exercise Training in Patients With Chronic Obstructive Pulmonary Disease: A Randomized Trial
author Valderramas, Silvia Regina [UNIFESP]
author_facet Valderramas, Silvia Regina [UNIFESP]
Atallah, Álvaro Nagib [UNIFESP]
author_role author
author2 Atallah, Álvaro Nagib [UNIFESP]
author2_role author
dc.contributor.none.fl_str_mv Evangel Univ Parana
Universidade Federal de São Paulo (UNIFESP)
Brasilian Cochrane Ctr
dc.contributor.author.fl_str_mv Valderramas, Silvia Regina [UNIFESP]
Atallah, Álvaro Nagib [UNIFESP]
dc.subject.por.fl_str_mv chronic obstructive pulmonary disease
COPD
hypertonic
saline
exercises
dyspnea
topic chronic obstructive pulmonary disease
COPD
hypertonic
saline
exercises
dyspnea
description BACKGROUND: Inhaled hypertonic saline is used for bronchial challenge and sputum induction in patients with chronic obstructive pulmonary disease (COPD). We studied the effects of saline aerosol inhalation before each exercise session in an 8-week pulmonary rehabilitation program. METHODS: This was a double-blind randomized parallel controlled trial, conducted at an outpatient clinic. Sixty-eight subjects with COPD (mean age 67 +/- 6.5 y, percent of predicted FEV(1) 47 +/- 21) were randomized to inhale either 3% hypertonic saline (34 subjects) or normal saline (34 subjects) before each exercise session in an 8-week exercise program that had 3 sessions per week. We measured 6-min walk distance, dyspnea, and quality of life (with the Medical Outcomes Study 36-item short-form health survey). RESULTS: After the 8-week exercise program, both groups' mean 6-min walk distance had significantly increased: from 195 +/- 92 m to 251 +/- 97 m (P <.001) in the hypertonic-saline group, and from 237 +/- 93 m to 441 +/- 121 m in the normal-saline group (P <.001). The normal-saline group had greater improvement than the hypertonic-saline group (P <.001). Dyspnea score improved from 3.1 +/- 0.9 to 2.3 +/- 0.8 (P <.01) in the hypertonic-saline group, and from 3.5 +/- 0.2 to 2.3 +/- 1.0 (P <.01) in the normal-saline group. Quality of life also significantly improved, except for the physical-functioning and social aspect domains in the hypertonic-saline group. Adverse effects (cough or bronchospasm) occurred in 4 patients (12%) in the hypertonic-saline group. CONCLUSIONS: The improvement in 6-min walk distance was greater with normal saline than with hypertonic saline. Hypertonic saline was associated with adverse effects. It is unclear whether the only predictor of improved functional exercise capacity was exercise training.
publishDate 2009
dc.date.none.fl_str_mv 2009-03-01
2018-06-18T11:35:35Z
2018-06-18T11:35:35Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://rc.rcjournal.com/content/54/3/327
Respiratory Care. Irving: Daedalus Enterprises Inc, v. 54, n. 3, p. 327-333, 2009.
0020-1324
http://repositorio.unifesp.br/handle/11600/45210
WOS:000264112600005
url http://rc.rcjournal.com/content/54/3/327
http://repositorio.unifesp.br/handle/11600/45210
identifier_str_mv Respiratory Care. Irving: Daedalus Enterprises Inc, v. 54, n. 3, p. 327-333, 2009.
0020-1324
WOS:000264112600005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Respiratory Care
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 327-333
dc.publisher.none.fl_str_mv Daedalus Enterprises Inc
publisher.none.fl_str_mv Daedalus Enterprises Inc
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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