Effectiveness and Safety of Hypertonic Saline Inhalation Combined With Exercise Training in Patients With Chronic Obstructive Pulmonary Disease: A Randomized Trial
Autor(a) principal: | |
---|---|
Data de Publicação: | 2009 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://rc.rcjournal.com/content/54/3/327 http://repositorio.unifesp.br/handle/11600/45210 |
Resumo: | BACKGROUND: Inhaled hypertonic saline is used for bronchial challenge and sputum induction in patients with chronic obstructive pulmonary disease (COPD). We studied the effects of saline aerosol inhalation before each exercise session in an 8-week pulmonary rehabilitation program. METHODS: This was a double-blind randomized parallel controlled trial, conducted at an outpatient clinic. Sixty-eight subjects with COPD (mean age 67 +/- 6.5 y, percent of predicted FEV(1) 47 +/- 21) were randomized to inhale either 3% hypertonic saline (34 subjects) or normal saline (34 subjects) before each exercise session in an 8-week exercise program that had 3 sessions per week. We measured 6-min walk distance, dyspnea, and quality of life (with the Medical Outcomes Study 36-item short-form health survey). RESULTS: After the 8-week exercise program, both groups' mean 6-min walk distance had significantly increased: from 195 +/- 92 m to 251 +/- 97 m (P <.001) in the hypertonic-saline group, and from 237 +/- 93 m to 441 +/- 121 m in the normal-saline group (P <.001). The normal-saline group had greater improvement than the hypertonic-saline group (P <.001). Dyspnea score improved from 3.1 +/- 0.9 to 2.3 +/- 0.8 (P <.01) in the hypertonic-saline group, and from 3.5 +/- 0.2 to 2.3 +/- 1.0 (P <.01) in the normal-saline group. Quality of life also significantly improved, except for the physical-functioning and social aspect domains in the hypertonic-saline group. Adverse effects (cough or bronchospasm) occurred in 4 patients (12%) in the hypertonic-saline group. CONCLUSIONS: The improvement in 6-min walk distance was greater with normal saline than with hypertonic saline. Hypertonic saline was associated with adverse effects. It is unclear whether the only predictor of improved functional exercise capacity was exercise training. |
id |
UFSP_e096cb5333338aa1b96a8e37999c8805 |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br/:11600/45210 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Effectiveness and Safety of Hypertonic Saline Inhalation Combined With Exercise Training in Patients With Chronic Obstructive Pulmonary Disease: A Randomized Trialchronic obstructive pulmonary diseaseCOPDhypertonicsalineexercisesdyspneaBACKGROUND: Inhaled hypertonic saline is used for bronchial challenge and sputum induction in patients with chronic obstructive pulmonary disease (COPD). We studied the effects of saline aerosol inhalation before each exercise session in an 8-week pulmonary rehabilitation program. METHODS: This was a double-blind randomized parallel controlled trial, conducted at an outpatient clinic. Sixty-eight subjects with COPD (mean age 67 +/- 6.5 y, percent of predicted FEV(1) 47 +/- 21) were randomized to inhale either 3% hypertonic saline (34 subjects) or normal saline (34 subjects) before each exercise session in an 8-week exercise program that had 3 sessions per week. We measured 6-min walk distance, dyspnea, and quality of life (with the Medical Outcomes Study 36-item short-form health survey). RESULTS: After the 8-week exercise program, both groups' mean 6-min walk distance had significantly increased: from 195 +/- 92 m to 251 +/- 97 m (P <.001) in the hypertonic-saline group, and from 237 +/- 93 m to 441 +/- 121 m in the normal-saline group (P <.001). The normal-saline group had greater improvement than the hypertonic-saline group (P <.001). Dyspnea score improved from 3.1 +/- 0.9 to 2.3 +/- 0.8 (P <.01) in the hypertonic-saline group, and from 3.5 +/- 0.2 to 2.3 +/- 1.0 (P <.01) in the normal-saline group. Quality of life also significantly improved, except for the physical-functioning and social aspect domains in the hypertonic-saline group. Adverse effects (cough or bronchospasm) occurred in 4 patients (12%) in the hypertonic-saline group. CONCLUSIONS: The improvement in 6-min walk distance was greater with normal saline than with hypertonic saline. Hypertonic saline was associated with adverse effects. It is unclear whether the only predictor of improved functional exercise capacity was exercise training.Evangel Univ Parana, Dept Physiotherapy, Div Resp Rehabil, Curitiba, Parana, BrazilUniv Fed Sao Paulo, Escola Paulista Med, Dept Emergency Med, Sao Paulo, BrazilBrasilian Cochrane Ctr, Sao Paulo, BrazilUniv Fed Sao Paulo, Escola Paulista Med, Dept Emergency Med, Sao Paulo, BrazilWeb of ScienceDaedalus Enterprises IncEvangel Univ ParanaUniversidade Federal de São Paulo (UNIFESP)Brasilian Cochrane CtrValderramas, Silvia Regina [UNIFESP]Atallah, Álvaro Nagib [UNIFESP]2018-06-18T11:35:35Z2018-06-18T11:35:35Z2009-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion327-333http://rc.rcjournal.com/content/54/3/327Respiratory Care. Irving: Daedalus Enterprises Inc, v. 54, n. 3, p. 327-333, 2009.0020-1324http://repositorio.unifesp.br/handle/11600/45210WOS:000264112600005engRespiratory Careinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-05-02T15:52:34Zoai:repositorio.unifesp.br/:11600/45210Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-05-02T15:52:34Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Effectiveness and Safety of Hypertonic Saline Inhalation Combined With Exercise Training in Patients With Chronic Obstructive Pulmonary Disease: A Randomized Trial |
title |
Effectiveness and Safety of Hypertonic Saline Inhalation Combined With Exercise Training in Patients With Chronic Obstructive Pulmonary Disease: A Randomized Trial |
spellingShingle |
Effectiveness and Safety of Hypertonic Saline Inhalation Combined With Exercise Training in Patients With Chronic Obstructive Pulmonary Disease: A Randomized Trial Valderramas, Silvia Regina [UNIFESP] chronic obstructive pulmonary disease COPD hypertonic saline exercises dyspnea |
title_short |
Effectiveness and Safety of Hypertonic Saline Inhalation Combined With Exercise Training in Patients With Chronic Obstructive Pulmonary Disease: A Randomized Trial |
title_full |
Effectiveness and Safety of Hypertonic Saline Inhalation Combined With Exercise Training in Patients With Chronic Obstructive Pulmonary Disease: A Randomized Trial |
title_fullStr |
Effectiveness and Safety of Hypertonic Saline Inhalation Combined With Exercise Training in Patients With Chronic Obstructive Pulmonary Disease: A Randomized Trial |
title_full_unstemmed |
Effectiveness and Safety of Hypertonic Saline Inhalation Combined With Exercise Training in Patients With Chronic Obstructive Pulmonary Disease: A Randomized Trial |
title_sort |
Effectiveness and Safety of Hypertonic Saline Inhalation Combined With Exercise Training in Patients With Chronic Obstructive Pulmonary Disease: A Randomized Trial |
author |
Valderramas, Silvia Regina [UNIFESP] |
author_facet |
Valderramas, Silvia Regina [UNIFESP] Atallah, Álvaro Nagib [UNIFESP] |
author_role |
author |
author2 |
Atallah, Álvaro Nagib [UNIFESP] |
author2_role |
author |
dc.contributor.none.fl_str_mv |
Evangel Univ Parana Universidade Federal de São Paulo (UNIFESP) Brasilian Cochrane Ctr |
dc.contributor.author.fl_str_mv |
Valderramas, Silvia Regina [UNIFESP] Atallah, Álvaro Nagib [UNIFESP] |
dc.subject.por.fl_str_mv |
chronic obstructive pulmonary disease COPD hypertonic saline exercises dyspnea |
topic |
chronic obstructive pulmonary disease COPD hypertonic saline exercises dyspnea |
description |
BACKGROUND: Inhaled hypertonic saline is used for bronchial challenge and sputum induction in patients with chronic obstructive pulmonary disease (COPD). We studied the effects of saline aerosol inhalation before each exercise session in an 8-week pulmonary rehabilitation program. METHODS: This was a double-blind randomized parallel controlled trial, conducted at an outpatient clinic. Sixty-eight subjects with COPD (mean age 67 +/- 6.5 y, percent of predicted FEV(1) 47 +/- 21) were randomized to inhale either 3% hypertonic saline (34 subjects) or normal saline (34 subjects) before each exercise session in an 8-week exercise program that had 3 sessions per week. We measured 6-min walk distance, dyspnea, and quality of life (with the Medical Outcomes Study 36-item short-form health survey). RESULTS: After the 8-week exercise program, both groups' mean 6-min walk distance had significantly increased: from 195 +/- 92 m to 251 +/- 97 m (P <.001) in the hypertonic-saline group, and from 237 +/- 93 m to 441 +/- 121 m in the normal-saline group (P <.001). The normal-saline group had greater improvement than the hypertonic-saline group (P <.001). Dyspnea score improved from 3.1 +/- 0.9 to 2.3 +/- 0.8 (P <.01) in the hypertonic-saline group, and from 3.5 +/- 0.2 to 2.3 +/- 1.0 (P <.01) in the normal-saline group. Quality of life also significantly improved, except for the physical-functioning and social aspect domains in the hypertonic-saline group. Adverse effects (cough or bronchospasm) occurred in 4 patients (12%) in the hypertonic-saline group. CONCLUSIONS: The improvement in 6-min walk distance was greater with normal saline than with hypertonic saline. Hypertonic saline was associated with adverse effects. It is unclear whether the only predictor of improved functional exercise capacity was exercise training. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-03-01 2018-06-18T11:35:35Z 2018-06-18T11:35:35Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://rc.rcjournal.com/content/54/3/327 Respiratory Care. Irving: Daedalus Enterprises Inc, v. 54, n. 3, p. 327-333, 2009. 0020-1324 http://repositorio.unifesp.br/handle/11600/45210 WOS:000264112600005 |
url |
http://rc.rcjournal.com/content/54/3/327 http://repositorio.unifesp.br/handle/11600/45210 |
identifier_str_mv |
Respiratory Care. Irving: Daedalus Enterprises Inc, v. 54, n. 3, p. 327-333, 2009. 0020-1324 WOS:000264112600005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Respiratory Care |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
327-333 |
dc.publisher.none.fl_str_mv |
Daedalus Enterprises Inc |
publisher.none.fl_str_mv |
Daedalus Enterprises Inc |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268413051142144 |