Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates

Detalhes bibliográficos
Autor(a) principal: Travassos, Luiz R. [UNIFESP]
Data de Publicação: 2017
Outros Autores: Taborda, Carlos P. [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
dARK ID: ark:/48912/00130000017vm
DOI: 10.3389/fimmu.2017.00224
Texto Completo: http://dx.doi.org/10.3389/fimmu.2017.00224
https://repositorio.unifesp.br/handle/11600/54931
Resumo: Dimorphic fungi are agents of systemic mycoses associated with significant morbidity and frequent lethality in the Americas. Among the pathogenic species are Paracoccidioides brasiliensis and Paracoccidioides lutzii, which predominate in South America
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spelling Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine CandidatespeptidevaccineantibodyfungiParacoccidioidesDimorphic fungi are agents of systemic mycoses associated with significant morbidity and frequent lethality in the Americas. Among the pathogenic species are Paracoccidioides brasiliensis and Paracoccidioides lutzii, which predominate in South AmericaHistoplasma capsulatum, Coccidioides posadasii, and Coccidioides immitis, and the Sporothrix spp. complex are other important pathogens. Associated with dimorphic fungi other important infections are caused by yeast such as Candida spp. and Cryptococcus spp. or mold such as Aspergillus spp., which are also fungal agents of deadly infections. Nowadays, the actual tendency of therapy is the development of a pan-fungal vaccine. This is, however, not easy because of the complexity of eukaryotic cells and the particularities of different species and isolates. Albeit there are several experimental vaccines being studied, we will focus mainly on peptide vaccines or epitopes of T-cell receptors inducing protective fungal responses. These peptides can be carried by antibody inducing beta-( 1,3)-glucan oligo or polysaccharides, or be mixed with them for administration. The present review discusses the efficacy of linear peptide epitopes in the context of antifungal immunization and vaccine proposition.Univ Fed Sao Paulo, Dept Microbiol Immunol & Parasitol, Sao Paulo, BrazilUniv Fed Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo, BrazilUniv Fed Sao Paulo, Lab Med Mycol IMTSP HCFMUSP LIM53, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Microbiol Immunol & Parasitol, Sao Paulo, BrazilUniv Fed Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo, BrazilUniv Fed Sao Paulo, Lab Med Mycol IMTSP HCFMUSP LIM53, Sao Paulo, BrazilWeb of ScienceFAPESPCAPESFAPESP: 2016/08730-6FAPESP: 2010/51423-0Frontiers Media Sa2020-07-17T14:02:39Z2020-07-17T14:02:39Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion-application/pdfhttp://dx.doi.org/10.3389/fimmu.2017.00224Frontiers In Immunology. Lausanne, v. 8, p. -, 2017.10.3389/fimmu.2017.00224WOS000395863200001.pdf1664-3224https://repositorio.unifesp.br/handle/11600/54931WOS:000395863200001ark:/48912/00130000017vmengFrontiers In ImmunologyLausanneinfo:eu-repo/semantics/openAccessTravassos, Luiz R. [UNIFESP]Taborda, Carlos P. [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-10T03:35:40Zoai:repositorio.unifesp.br/:11600/54931Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T19:50:19.187993Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates
title Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates
spellingShingle Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates
Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates
Travassos, Luiz R. [UNIFESP]
peptide
vaccine
antibody
fungi
Paracoccidioides
Travassos, Luiz R. [UNIFESP]
peptide
vaccine
antibody
fungi
Paracoccidioides
title_short Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates
title_full Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates
title_fullStr Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates
Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates
title_full_unstemmed Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates
Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates
title_sort Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates
author Travassos, Luiz R. [UNIFESP]
author_facet Travassos, Luiz R. [UNIFESP]
Travassos, Luiz R. [UNIFESP]
Taborda, Carlos P. [UNIFESP]
Taborda, Carlos P. [UNIFESP]
author_role author
author2 Taborda, Carlos P. [UNIFESP]
author2_role author
dc.contributor.author.fl_str_mv Travassos, Luiz R. [UNIFESP]
Taborda, Carlos P. [UNIFESP]
dc.subject.por.fl_str_mv peptide
vaccine
antibody
fungi
Paracoccidioides
topic peptide
vaccine
antibody
fungi
Paracoccidioides
description Dimorphic fungi are agents of systemic mycoses associated with significant morbidity and frequent lethality in the Americas. Among the pathogenic species are Paracoccidioides brasiliensis and Paracoccidioides lutzii, which predominate in South America
publishDate 2017
dc.date.none.fl_str_mv 2017
2020-07-17T14:02:39Z
2020-07-17T14:02:39Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3389/fimmu.2017.00224
Frontiers In Immunology. Lausanne, v. 8, p. -, 2017.
10.3389/fimmu.2017.00224
WOS000395863200001.pdf
1664-3224
https://repositorio.unifesp.br/handle/11600/54931
WOS:000395863200001
dc.identifier.dark.fl_str_mv ark:/48912/00130000017vm
url http://dx.doi.org/10.3389/fimmu.2017.00224
https://repositorio.unifesp.br/handle/11600/54931
identifier_str_mv Frontiers In Immunology. Lausanne, v. 8, p. -, 2017.
10.3389/fimmu.2017.00224
WOS000395863200001.pdf
1664-3224
WOS:000395863200001
ark:/48912/00130000017vm
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Frontiers In Immunology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv -
application/pdf
dc.coverage.none.fl_str_mv Lausanne
dc.publisher.none.fl_str_mv Frontiers Media Sa
publisher.none.fl_str_mv Frontiers Media Sa
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1822252437094793216
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2017.00224

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