Structural and functional analyses of the optic nerve and lateral geniculate nucleus in glaucoma
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| dARK ID: | ark:/48912/0013000005df9 |
| DOI: | 10.1371/journal.pone.0194038 |
| Texto Completo: | http://dx.doi.org/10.1371/journal.pone.0194038 https://repositorio.unifesp.br/handle/11600/55803 |
Resumo: | Purpose To analyze the correlation between structural characteristics of intraorbital optic nerve (ION) and lateral geniculate nucleus (LGN) measured by 3-Tesla magnetic resonance imaging (3T MRI), and the severity of glaucomatous damage. Methods In this cross-sectional study, 41 glaucoma patients and 12 age-and sex-matched controls underwent standard automated perimetry (SAP) and frequency doubling technology (FDT) as functional evaluation |
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Repositório Institucional da UNIFESP |
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3465 |
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Structural and functional analyses of the optic nerve and lateral geniculate nucleus in glaucomaPurpose To analyze the correlation between structural characteristics of intraorbital optic nerve (ION) and lateral geniculate nucleus (LGN) measured by 3-Tesla magnetic resonance imaging (3T MRI), and the severity of glaucomatous damage. Methods In this cross-sectional study, 41 glaucoma patients and 12 age-and sex-matched controls underwent standard automated perimetry (SAP) and frequency doubling technology (FDT) as functional evaluationoptic disc stereophotograph, spectral-domain optical coherence tomography (OCT) and confocal scanning laser tomography as ocular structural evaluationand 3T MRI. Structure-structure and structure-function correlation were performed using bootstrap resampling method for clustered data. Results The ION mean diameter and cross-sectional area were different between glaucoma and control groups at 5mm and 10mm (all, p <= 0.011) from the globe, but not at 15mm (both, p >= 0.067). LGN height was significantly lower in glaucoma group (p = 0.005). OCT rim area and functional parameters (SAP and FDT) correlated significantly with all ION segments, showing stronger correlations at 10 and 15 mm. ION parameters at 10 and 15 mm presented mild-to-moderate correlation with OCT peripapillary nerve fiber layer thickness, and ION at 15mm had mild association with the neuroretinal rim area on stereophotographs. Although LGN height was significantly smaller in glaucoma group (p = 0.005), LGN parameters were not associated with any ocular structural or functional parameter. Conclusion Assessment of central and peripheral nervous systems using 3T MRI confirmed that glaucoma patients had smaller ION dimensions and LGN height compared to the control group. In general, ION dimensions presented mild to moderate correlations with functional and ocular structural parameters. Although ION had significant correlations at any distance from the eye, the ION distal locations correlated better with OCT results and functional parameters. However, LGN parameters were not associated with functional or ocular structural parameters.Univ Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, SP, BrazilHosp Israelita Albert Einstein, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, SP, BrazilWeb of ScienceCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) Foundation, Ministry of Education of BrazilCAPES: 9033/11-4Public Library Science2020-07-20T16:31:14Z2020-07-20T16:31:14Z2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion-application/pdfhttp://dx.doi.org/10.1371/journal.pone.0194038Plos One. San Francisco, v. 13, n. 3, 2018.10.1371/journal.pone.0194038WOS000428168400010.pdf1932-6203https://repositorio.unifesp.br/handle/11600/55803WOS:000428168400010ark:/48912/0013000005df9engPlos OneSan Franciscoinfo:eu-repo/semantics/openAccessFurlanetto, Rafael Lacerda [UNIFESP]Teixeira, Sergio Henrique [UNIFESP]Gracitelli, Carolina Pelegrini Barbosa [UNIFESP]Lottenberg, Claudio Luiz [UNIFESP]Emori, FabianoMichelan, MichelAmaro, Edson, Jr.Paranhos Junior, Augusto [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-09T23:30:11Zoai:repositorio.unifesp.br/:11600/55803Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T19:58:51.979648Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Structural and functional analyses of the optic nerve and lateral geniculate nucleus in glaucoma |
| title |
Structural and functional analyses of the optic nerve and lateral geniculate nucleus in glaucoma |
| spellingShingle |
Structural and functional analyses of the optic nerve and lateral geniculate nucleus in glaucoma Structural and functional analyses of the optic nerve and lateral geniculate nucleus in glaucoma Furlanetto, Rafael Lacerda [UNIFESP] Furlanetto, Rafael Lacerda [UNIFESP] |
| title_short |
Structural and functional analyses of the optic nerve and lateral geniculate nucleus in glaucoma |
| title_full |
Structural and functional analyses of the optic nerve and lateral geniculate nucleus in glaucoma |
| title_fullStr |
Structural and functional analyses of the optic nerve and lateral geniculate nucleus in glaucoma Structural and functional analyses of the optic nerve and lateral geniculate nucleus in glaucoma |
| title_full_unstemmed |
Structural and functional analyses of the optic nerve and lateral geniculate nucleus in glaucoma Structural and functional analyses of the optic nerve and lateral geniculate nucleus in glaucoma |
| title_sort |
Structural and functional analyses of the optic nerve and lateral geniculate nucleus in glaucoma |
| author |
Furlanetto, Rafael Lacerda [UNIFESP] |
| author_facet |
Furlanetto, Rafael Lacerda [UNIFESP] Furlanetto, Rafael Lacerda [UNIFESP] Teixeira, Sergio Henrique [UNIFESP] Gracitelli, Carolina Pelegrini Barbosa [UNIFESP] Lottenberg, Claudio Luiz [UNIFESP] Emori, Fabiano Michelan, Michel Amaro, Edson, Jr. Paranhos Junior, Augusto [UNIFESP] Teixeira, Sergio Henrique [UNIFESP] Gracitelli, Carolina Pelegrini Barbosa [UNIFESP] Lottenberg, Claudio Luiz [UNIFESP] Emori, Fabiano Michelan, Michel Amaro, Edson, Jr. Paranhos Junior, Augusto [UNIFESP] |
| author_role |
author |
| author2 |
Teixeira, Sergio Henrique [UNIFESP] Gracitelli, Carolina Pelegrini Barbosa [UNIFESP] Lottenberg, Claudio Luiz [UNIFESP] Emori, Fabiano Michelan, Michel Amaro, Edson, Jr. Paranhos Junior, Augusto [UNIFESP] |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Furlanetto, Rafael Lacerda [UNIFESP] Teixeira, Sergio Henrique [UNIFESP] Gracitelli, Carolina Pelegrini Barbosa [UNIFESP] Lottenberg, Claudio Luiz [UNIFESP] Emori, Fabiano Michelan, Michel Amaro, Edson, Jr. Paranhos Junior, Augusto [UNIFESP] |
| description |
Purpose To analyze the correlation between structural characteristics of intraorbital optic nerve (ION) and lateral geniculate nucleus (LGN) measured by 3-Tesla magnetic resonance imaging (3T MRI), and the severity of glaucomatous damage. Methods In this cross-sectional study, 41 glaucoma patients and 12 age-and sex-matched controls underwent standard automated perimetry (SAP) and frequency doubling technology (FDT) as functional evaluation |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018 2020-07-20T16:31:14Z 2020-07-20T16:31:14Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1371/journal.pone.0194038 Plos One. San Francisco, v. 13, n. 3, 2018. 10.1371/journal.pone.0194038 WOS000428168400010.pdf 1932-6203 https://repositorio.unifesp.br/handle/11600/55803 WOS:000428168400010 |
| dc.identifier.dark.fl_str_mv |
ark:/48912/0013000005df9 |
| url |
http://dx.doi.org/10.1371/journal.pone.0194038 https://repositorio.unifesp.br/handle/11600/55803 |
| identifier_str_mv |
Plos One. San Francisco, v. 13, n. 3, 2018. 10.1371/journal.pone.0194038 WOS000428168400010.pdf 1932-6203 WOS:000428168400010 ark:/48912/0013000005df9 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Plos One |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
- application/pdf |
| dc.coverage.none.fl_str_mv |
San Francisco |
| dc.publisher.none.fl_str_mv |
Public Library Science |
| publisher.none.fl_str_mv |
Public Library Science |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| instname_str |
Universidade Federal de São Paulo (UNIFESP) |
| instacron_str |
UNIFESP |
| institution |
UNIFESP |
| reponame_str |
Repositório Institucional da UNIFESP |
| collection |
Repositório Institucional da UNIFESP |
| repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
| repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
| _version_ |
1822250200050171904 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0194038 |