Células-tronco derivadas de tecido adiposo humano: desafios atuais e perspectivas clínicas

Detalhes bibliográficos
Autor(a) principal: Yarak, Samira [UNIFESP]
Data de Publicação: 2010
Outros Autores: Okamoto, Oswaldo Keith [UNIFESP]
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNIFESP
dARK ID: ark:/48912/001300000qxkd
DOI: 10.1590/S0365-05962010000500008
Texto Completo: http://dx.doi.org/10.1590/S0365-05962010000500008
http://repositorio.unifesp.br/handle/11600/5999
Resumo: Adult or somatic stem cells hold great promise for tissue regeneration. Currently, one major scientific interest is focused on the basic biology and clinical application of mesenchymal stem cells. Adipose tissue-derived stem cells share similar characteristics with bone marrow mesenchymal stem cells, but have some advantages including harvesting through a less invasive surgical procedure. Moreover, adipose tissue-derived stem cells have the potential to differentiate into cells of mesodermal origin, such as adipocytes, cartilage, bone, and skeletal muscle, as well as cells of non-mesodermal lineage, such as hepatocytes, pancreatic endocrine cells, neurons, cardiomyocytes, and vascular endothelial cells. There are, however, inconsistencies in the scientific literature regarding methods for harvesting adipose tissue and for isolating, characterizing and handling adipose tissue-derived stem cells. Future clinical applications of adipose tissue-derived stem cells rely on more defined and widespread methods for obtaining cells of clinical grade quality. In this review, current methods in adipose tissue-derived stem cell research are discussed with emphasis on strategies designed for future applications in regenerative medicine and possible challenges along the way.
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spelling Células-tronco derivadas de tecido adiposo humano: desafios atuais e perspectivas clínicasHuman adipose-derived stem cells: current challenges and clinical perspectivesAdipocytesAdipose tissueAdult stem cellsTissue therapyAdipócitosCélulas-tronco adultasTecido adiposoTerapia tissularAdult or somatic stem cells hold great promise for tissue regeneration. Currently, one major scientific interest is focused on the basic biology and clinical application of mesenchymal stem cells. Adipose tissue-derived stem cells share similar characteristics with bone marrow mesenchymal stem cells, but have some advantages including harvesting through a less invasive surgical procedure. Moreover, adipose tissue-derived stem cells have the potential to differentiate into cells of mesodermal origin, such as adipocytes, cartilage, bone, and skeletal muscle, as well as cells of non-mesodermal lineage, such as hepatocytes, pancreatic endocrine cells, neurons, cardiomyocytes, and vascular endothelial cells. There are, however, inconsistencies in the scientific literature regarding methods for harvesting adipose tissue and for isolating, characterizing and handling adipose tissue-derived stem cells. Future clinical applications of adipose tissue-derived stem cells rely on more defined and widespread methods for obtaining cells of clinical grade quality. In this review, current methods in adipose tissue-derived stem cell research are discussed with emphasis on strategies designed for future applications in regenerative medicine and possible challenges along the way.As células-tronco adultas ou somáticas detêm grande promessa para a reparação e regeneração de tecidos. Atualmente, o interesse dos cientistas é contínuo na investigação da biologia de células-tronco mesenquimais, tanto em aspectos básicos, quanto no potencial de aplicações terapêuticas. As células-tronco adultas derivadas do estroma do tecido adiposo, em comparação com as células-tronco derivadas do estroma da medula óssea, apresentam como vantagem o método fácil de obtenção da fonte tecidual. As células-tronco adultas derivadas do estroma do tecido adiposo apresentam potencial para se diferenciarem em células de tecidos mesodérmicos, como os adipócitos, as cartilagens, os ossos e o músculo esquelético e não mesodérmicos, como os hepatócitos, as células pancreáticas endócrinas, os neurônios, os hepatócitos e as células endoteliais vasculares. Entretanto, os dados disponíveis na literatura científica sobre as características das células-tronco adultas derivadas do estroma do tecido adiposo e os procedimentos para sua obtenção e manipulação no laboratório são inconsistentes. É necessário o desenvolvimento de metodologias e procedimentos eficazes de isolamento dessas células para obtenção de células em quantidade e qualidade suficientes para aplicação terapêutica. Nesta revisão, são discutidos os métodos correntes de coleta de tecido adiposo, isolamento e caracterização de células-tronco adultas derivadas do estroma do tecido adiposo, com ênfase na futura aplicação em medicina regenerativa e nos possíveis desafios nesse recente campo da ciência.Universidade Federal do Vale do São FranciscoUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de PatologiaUniversidade Federal de São Paulo (UNIFESP) Departamento de Neurologia e NeurocirurgiaUNIFESP, EPM, Depto. de PatologiaUNIFESP, Depto. de Neurologia e NeurocirurgiaSciELOSociedade Brasileira de DermatologiaUniversidade Federal do Vale do São FranciscoUniversidade Federal de São Paulo (UNIFESP)Yarak, Samira [UNIFESP]Okamoto, Oswaldo Keith [UNIFESP]2015-06-14T13:41:57Z2015-06-14T13:41:57Z2010-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion647-656application/pdfhttp://dx.doi.org/10.1590/S0365-05962010000500008Anais Brasileiros de Dermatologia. Sociedade Brasileira de Dermatologia, v. 85, n. 5, p. 647-656, 2010.10.1590/S0365-05962010000500008S0365-05962010000500008.pdf0365-0596S0365-05962010000500008http://repositorio.unifesp.br/handle/11600/5999WOS:000285248300007ark:/48912/001300000qxkdporAnais Brasileiros de Dermatologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-28T21:04:50Zoai:repositorio.unifesp.br/:11600/5999Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:32:08.176709Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Células-tronco derivadas de tecido adiposo humano: desafios atuais e perspectivas clínicas
Human adipose-derived stem cells: current challenges and clinical perspectives
title Células-tronco derivadas de tecido adiposo humano: desafios atuais e perspectivas clínicas
spellingShingle Células-tronco derivadas de tecido adiposo humano: desafios atuais e perspectivas clínicas
Células-tronco derivadas de tecido adiposo humano: desafios atuais e perspectivas clínicas
Yarak, Samira [UNIFESP]
Adipocytes
Adipose tissue
Adult stem cells
Tissue therapy
Adipócitos
Células-tronco adultas
Tecido adiposo
Terapia tissular
Yarak, Samira [UNIFESP]
Adipocytes
Adipose tissue
Adult stem cells
Tissue therapy
Adipócitos
Células-tronco adultas
Tecido adiposo
Terapia tissular
title_short Células-tronco derivadas de tecido adiposo humano: desafios atuais e perspectivas clínicas
title_full Células-tronco derivadas de tecido adiposo humano: desafios atuais e perspectivas clínicas
title_fullStr Células-tronco derivadas de tecido adiposo humano: desafios atuais e perspectivas clínicas
Células-tronco derivadas de tecido adiposo humano: desafios atuais e perspectivas clínicas
title_full_unstemmed Células-tronco derivadas de tecido adiposo humano: desafios atuais e perspectivas clínicas
Células-tronco derivadas de tecido adiposo humano: desafios atuais e perspectivas clínicas
title_sort Células-tronco derivadas de tecido adiposo humano: desafios atuais e perspectivas clínicas
author Yarak, Samira [UNIFESP]
author_facet Yarak, Samira [UNIFESP]
Yarak, Samira [UNIFESP]
Okamoto, Oswaldo Keith [UNIFESP]
Okamoto, Oswaldo Keith [UNIFESP]
author_role author
author2 Okamoto, Oswaldo Keith [UNIFESP]
author2_role author
dc.contributor.none.fl_str_mv Universidade Federal do Vale do São Francisco
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Yarak, Samira [UNIFESP]
Okamoto, Oswaldo Keith [UNIFESP]
dc.subject.por.fl_str_mv Adipocytes
Adipose tissue
Adult stem cells
Tissue therapy
Adipócitos
Células-tronco adultas
Tecido adiposo
Terapia tissular
topic Adipocytes
Adipose tissue
Adult stem cells
Tissue therapy
Adipócitos
Células-tronco adultas
Tecido adiposo
Terapia tissular
description Adult or somatic stem cells hold great promise for tissue regeneration. Currently, one major scientific interest is focused on the basic biology and clinical application of mesenchymal stem cells. Adipose tissue-derived stem cells share similar characteristics with bone marrow mesenchymal stem cells, but have some advantages including harvesting through a less invasive surgical procedure. Moreover, adipose tissue-derived stem cells have the potential to differentiate into cells of mesodermal origin, such as adipocytes, cartilage, bone, and skeletal muscle, as well as cells of non-mesodermal lineage, such as hepatocytes, pancreatic endocrine cells, neurons, cardiomyocytes, and vascular endothelial cells. There are, however, inconsistencies in the scientific literature regarding methods for harvesting adipose tissue and for isolating, characterizing and handling adipose tissue-derived stem cells. Future clinical applications of adipose tissue-derived stem cells rely on more defined and widespread methods for obtaining cells of clinical grade quality. In this review, current methods in adipose tissue-derived stem cell research are discussed with emphasis on strategies designed for future applications in regenerative medicine and possible challenges along the way.
publishDate 2010
dc.date.none.fl_str_mv 2010-10-01
2015-06-14T13:41:57Z
2015-06-14T13:41:57Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0365-05962010000500008
Anais Brasileiros de Dermatologia. Sociedade Brasileira de Dermatologia, v. 85, n. 5, p. 647-656, 2010.
10.1590/S0365-05962010000500008
S0365-05962010000500008.pdf
0365-0596
S0365-05962010000500008
http://repositorio.unifesp.br/handle/11600/5999
WOS:000285248300007
dc.identifier.dark.fl_str_mv ark:/48912/001300000qxkd
url http://dx.doi.org/10.1590/S0365-05962010000500008
http://repositorio.unifesp.br/handle/11600/5999
identifier_str_mv Anais Brasileiros de Dermatologia. Sociedade Brasileira de Dermatologia, v. 85, n. 5, p. 647-656, 2010.
10.1590/S0365-05962010000500008
S0365-05962010000500008.pdf
0365-0596
S0365-05962010000500008
WOS:000285248300007
ark:/48912/001300000qxkd
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Anais Brasileiros de Dermatologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 647-656
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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dc.identifier.doi.none.fl_str_mv 10.1590/S0365-05962010000500008

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