Is Lack of Sleep Capable of Inducing DNA Damage in Aged Skin?

Detalhes bibliográficos
Autor(a) principal: Kahan, Vanessa [UNIFESP]
Data de Publicação: 2014
Outros Autores: Ribeiro, Daniel Araki [UNIFESP], Egydio, Flavia [UNIFESP], Barros, L. A. [UNIFESP], Tomimori, Jane [UNIFESP], Tufik, Sergio [UNIFESP], Andersen, Monica Levy [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1159/000354915
http://repositorio.unifesp.br/handle/11600/37206
Resumo: Skin naturally changes with age, becoming more fragile. Various stimuli can alter skin integrity. the aim of this study was to evaluate whether sleep deprivation affects the integrity of DNA in skin and exacerbates the effects of aging. Fifteen-month old female Hairless mice underwent 72 h of paradoxical sleep deprivation or 15 days of chronic sleep restriction. Punch biopsies of the skin were taken to evaluate DNA damage by single cell gel (comet) assay. Neither paradoxical sleep deprivation nor sleep restriction increased genetic damage, measured by tail movement and tail intensity values. Taken together, the findings are consistent with the notion that aging overrides the effect of sleep loss on the genetic damage in elderly mice. (C) 2014 S. Karger AG, Basel
id UFSP_ec47c6585182589e67dc78bdc9dfbaf6
oai_identifier_str oai:repositorio.unifesp.br/:11600/37206
network_acronym_str UFSP
network_name_str Repositório Institucional da UNIFESP
repository_id_str 3465
spelling Is Lack of Sleep Capable of Inducing DNA Damage in Aged Skin?SkinElderlySleep deprivationMiceSingle cell gel (comet) assayDNA damageSkin naturally changes with age, becoming more fragile. Various stimuli can alter skin integrity. the aim of this study was to evaluate whether sleep deprivation affects the integrity of DNA in skin and exacerbates the effects of aging. Fifteen-month old female Hairless mice underwent 72 h of paradoxical sleep deprivation or 15 days of chronic sleep restriction. Punch biopsies of the skin were taken to evaluate DNA damage by single cell gel (comet) assay. Neither paradoxical sleep deprivation nor sleep restriction increased genetic damage, measured by tail movement and tail intensity values. Taken together, the findings are consistent with the notion that aging overrides the effect of sleep loss on the genetic damage in elderly mice. (C) 2014 S. Karger AG, BaselUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biociencias, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Dermatol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biociencias, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Dermatol, São Paulo, BrazilWeb of ScienceAssociacao Fundo de Incentivo a PesquisaConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)FAPESP: 09/04240-0FAPESP: 07/01228-4FAPESP: 11/14462-0KargerUniversidade Federal de São Paulo (UNIFESP)Kahan, Vanessa [UNIFESP]Ribeiro, Daniel Araki [UNIFESP]Egydio, Flavia [UNIFESP]Barros, L. A. [UNIFESP]Tomimori, Jane [UNIFESP]Tufik, Sergio [UNIFESP]Andersen, Monica Levy [UNIFESP]2016-01-24T14:35:01Z2016-01-24T14:35:01Z2014-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion127-131http://dx.doi.org/10.1159/000354915Skin Pharmacology and Physiology. Basel: Karger, v. 27, n. 3, p. 127-131, 2014.10.1159/0003549151660-5527http://repositorio.unifesp.br/handle/11600/37206WOS:000330633900003engSkin Pharmacology and Physiologyinfo:eu-repo/semantics/openAccesshttp://www.karger.com/Services/RightsPermissionsreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2016-01-24T12:35:01Zoai:repositorio.unifesp.br/:11600/37206Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652016-01-24T12:35:01Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Is Lack of Sleep Capable of Inducing DNA Damage in Aged Skin?
title Is Lack of Sleep Capable of Inducing DNA Damage in Aged Skin?
spellingShingle Is Lack of Sleep Capable of Inducing DNA Damage in Aged Skin?
Kahan, Vanessa [UNIFESP]
Skin
Elderly
Sleep deprivation
Mice
Single cell gel (comet) assay
DNA damage
title_short Is Lack of Sleep Capable of Inducing DNA Damage in Aged Skin?
title_full Is Lack of Sleep Capable of Inducing DNA Damage in Aged Skin?
title_fullStr Is Lack of Sleep Capable of Inducing DNA Damage in Aged Skin?
title_full_unstemmed Is Lack of Sleep Capable of Inducing DNA Damage in Aged Skin?
title_sort Is Lack of Sleep Capable of Inducing DNA Damage in Aged Skin?
author Kahan, Vanessa [UNIFESP]
author_facet Kahan, Vanessa [UNIFESP]
Ribeiro, Daniel Araki [UNIFESP]
Egydio, Flavia [UNIFESP]
Barros, L. A. [UNIFESP]
Tomimori, Jane [UNIFESP]
Tufik, Sergio [UNIFESP]
Andersen, Monica Levy [UNIFESP]
author_role author
author2 Ribeiro, Daniel Araki [UNIFESP]
Egydio, Flavia [UNIFESP]
Barros, L. A. [UNIFESP]
Tomimori, Jane [UNIFESP]
Tufik, Sergio [UNIFESP]
Andersen, Monica Levy [UNIFESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Kahan, Vanessa [UNIFESP]
Ribeiro, Daniel Araki [UNIFESP]
Egydio, Flavia [UNIFESP]
Barros, L. A. [UNIFESP]
Tomimori, Jane [UNIFESP]
Tufik, Sergio [UNIFESP]
Andersen, Monica Levy [UNIFESP]
dc.subject.por.fl_str_mv Skin
Elderly
Sleep deprivation
Mice
Single cell gel (comet) assay
DNA damage
topic Skin
Elderly
Sleep deprivation
Mice
Single cell gel (comet) assay
DNA damage
description Skin naturally changes with age, becoming more fragile. Various stimuli can alter skin integrity. the aim of this study was to evaluate whether sleep deprivation affects the integrity of DNA in skin and exacerbates the effects of aging. Fifteen-month old female Hairless mice underwent 72 h of paradoxical sleep deprivation or 15 days of chronic sleep restriction. Punch biopsies of the skin were taken to evaluate DNA damage by single cell gel (comet) assay. Neither paradoxical sleep deprivation nor sleep restriction increased genetic damage, measured by tail movement and tail intensity values. Taken together, the findings are consistent with the notion that aging overrides the effect of sleep loss on the genetic damage in elderly mice. (C) 2014 S. Karger AG, Basel
publishDate 2014
dc.date.none.fl_str_mv 2014-01-01
2016-01-24T14:35:01Z
2016-01-24T14:35:01Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1159/000354915
Skin Pharmacology and Physiology. Basel: Karger, v. 27, n. 3, p. 127-131, 2014.
10.1159/000354915
1660-5527
http://repositorio.unifesp.br/handle/11600/37206
WOS:000330633900003
url http://dx.doi.org/10.1159/000354915
http://repositorio.unifesp.br/handle/11600/37206
identifier_str_mv Skin Pharmacology and Physiology. Basel: Karger, v. 27, n. 3, p. 127-131, 2014.
10.1159/000354915
1660-5527
WOS:000330633900003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Skin Pharmacology and Physiology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
http://www.karger.com/Services/RightsPermissions
eu_rights_str_mv openAccess
rights_invalid_str_mv http://www.karger.com/Services/RightsPermissions
dc.format.none.fl_str_mv 127-131
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268382242930688

Registros relacionados