Histological analysis of autologous fascia graft implantation into the rabbit voice muscle

Detalhes bibliográficos
Autor(a) principal: Pinna, Bruno de Rezende [UNIFESP]
Data de Publicação: 2011
Outros Autores: Stávale, João Norberto [UNIFESP], Pontes, Paulo Augusto de Lima [UNIFESP], Brasil, Osiris de Oliveira Campones do [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S1808-86942011000200008
http://repositorio.unifesp.br/handle/11600/6421
Resumo: The ideal approach for the treatment of glottal insufficiency remains a challenge for laryngologists. AIM: This experimental study assessed the histological changes and fibrosis caused by autologous fascia lata grafts into the rabbit voice muscle. STUDY DESIGN: A clinical and experimental study. METHODS: A 0.2 × 0.2 cm fragment of autologous fascia lata was grafted into the right voice muscle of 14 adult rabbits. Animals were euthanized 30 or 60 days post-procedure and histology of the excised vocal folds was carried out. RESULTS: No extensive edema, necrosis or foreign body-type reaction was observed at any time. No significant inflammatory reaction or fibrosis was seen at 30 or 60 days. CONCLUSION: The presence of fascia lata in the rabbit voice muscle had no significant influence on inflammation, and does not increase fibrosis. Rabbit voice muscle shows good tolerance to fascia lata grafting.
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spelling Histological analysis of autologous fascia graft implantation into the rabbit voice muscleAnálise histológica em músculo vocal de coelhos submetidos a implante de fáscia lata autólogalaryngeal diseasesglottisfasciarabbitsvocal cordscoelhosdoenças da laringefasciaglotepregas vocaisThe ideal approach for the treatment of glottal insufficiency remains a challenge for laryngologists. AIM: This experimental study assessed the histological changes and fibrosis caused by autologous fascia lata grafts into the rabbit voice muscle. STUDY DESIGN: A clinical and experimental study. METHODS: A 0.2 × 0.2 cm fragment of autologous fascia lata was grafted into the right voice muscle of 14 adult rabbits. Animals were euthanized 30 or 60 days post-procedure and histology of the excised vocal folds was carried out. RESULTS: No extensive edema, necrosis or foreign body-type reaction was observed at any time. No significant inflammatory reaction or fibrosis was seen at 30 or 60 days. CONCLUSION: The presence of fascia lata in the rabbit voice muscle had no significant influence on inflammation, and does not increase fibrosis. Rabbit voice muscle shows good tolerance to fascia lata grafting.A apropriada abordagem no tratamento da insuficiência glótica causada por paralisa, cicatriz e atrofia de prega vocal é um desafio ao laringologista. OBJETIVO: O presente estudo avaliou as alterações histológicas e fibrose desencadeadas pelo enxerto autólogo de fáscia lata no músculo vocalde coelhos. FORMA DE ESTUDO: Clínico e Experimental. MATERIAL E MÉTODO: Foi realizado um estudo experimental com 14 coelhos adultos que foram submetidos a implante de fáscia lata autóloga medindo 0,2 x 0,2cm, no músculo vocal direito. Os animais foram sacrificados após 30 e 60 dias do procedimento, suas laringes removidas e submetidas a estudo histológico. RESULTADOS: Não foi observado edema extenso, área de necrose ou reação inflamatória do tipo corpo estranho. A reação inflamatória observada após 30 e 60 dias foi leve, bem como a fibrose desencadeada. CONCLUSÃO: A presença de fáscia lata autóloga no músculo vocal de coelho não desencadeou fibrose e resposta inflamatória significativa.UNIFESP- EPM Otorhinolaryngology and Head & Neck Surgery DepartmentUNIFESP Pathology DepartmentUNIFESP, EPM, Otorhinolaryngology and Head & Neck Surgery DepartmentUNIFESP, Pathology DepartmentSciELOAssociação Brasileira de Otorrinolaringologia e Cirurgia CervicofacialUniversidade Federal de São Paulo (UNIFESP)Pinna, Bruno de Rezende [UNIFESP]Stávale, João Norberto [UNIFESP]Pontes, Paulo Augusto de Lima [UNIFESP]Brasil, Osiris de Oliveira Campones do [UNIFESP]2015-06-14T13:43:02Z2015-06-14T13:43:02Z2011-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion185-190application/pdfapplication/pdfhttp://dx.doi.org/10.1590/S1808-86942011000200008Brazilian Journal of Otorhinolaryngology. Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial, v. 77, n. 2, p. 185-190, 2011.10.1590/S1808-86942011000200008S1808-86942011000200008-en.pdfS1808-86942011000200008-pt.pdf1808-8694S1808-86942011000200008http://repositorio.unifesp.br/handle/11600/6421WOS:000293578500008engBrazilian Journal of Otorhinolaryngologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-30T04:03:37Zoai:repositorio.unifesp.br/:11600/6421Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-30T04:03:37Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Histological analysis of autologous fascia graft implantation into the rabbit voice muscle
Análise histológica em músculo vocal de coelhos submetidos a implante de fáscia lata autóloga
title Histological analysis of autologous fascia graft implantation into the rabbit voice muscle
spellingShingle Histological analysis of autologous fascia graft implantation into the rabbit voice muscle
Pinna, Bruno de Rezende [UNIFESP]
laryngeal diseases
glottis
fascia
rabbits
vocal cords
coelhos
doenças da laringe
fascia
glote
pregas vocais
title_short Histological analysis of autologous fascia graft implantation into the rabbit voice muscle
title_full Histological analysis of autologous fascia graft implantation into the rabbit voice muscle
title_fullStr Histological analysis of autologous fascia graft implantation into the rabbit voice muscle
title_full_unstemmed Histological analysis of autologous fascia graft implantation into the rabbit voice muscle
title_sort Histological analysis of autologous fascia graft implantation into the rabbit voice muscle
author Pinna, Bruno de Rezende [UNIFESP]
author_facet Pinna, Bruno de Rezende [UNIFESP]
Stávale, João Norberto [UNIFESP]
Pontes, Paulo Augusto de Lima [UNIFESP]
Brasil, Osiris de Oliveira Campones do [UNIFESP]
author_role author
author2 Stávale, João Norberto [UNIFESP]
Pontes, Paulo Augusto de Lima [UNIFESP]
Brasil, Osiris de Oliveira Campones do [UNIFESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Pinna, Bruno de Rezende [UNIFESP]
Stávale, João Norberto [UNIFESP]
Pontes, Paulo Augusto de Lima [UNIFESP]
Brasil, Osiris de Oliveira Campones do [UNIFESP]
dc.subject.por.fl_str_mv laryngeal diseases
glottis
fascia
rabbits
vocal cords
coelhos
doenças da laringe
fascia
glote
pregas vocais
topic laryngeal diseases
glottis
fascia
rabbits
vocal cords
coelhos
doenças da laringe
fascia
glote
pregas vocais
description The ideal approach for the treatment of glottal insufficiency remains a challenge for laryngologists. AIM: This experimental study assessed the histological changes and fibrosis caused by autologous fascia lata grafts into the rabbit voice muscle. STUDY DESIGN: A clinical and experimental study. METHODS: A 0.2 × 0.2 cm fragment of autologous fascia lata was grafted into the right voice muscle of 14 adult rabbits. Animals were euthanized 30 or 60 days post-procedure and histology of the excised vocal folds was carried out. RESULTS: No extensive edema, necrosis or foreign body-type reaction was observed at any time. No significant inflammatory reaction or fibrosis was seen at 30 or 60 days. CONCLUSION: The presence of fascia lata in the rabbit voice muscle had no significant influence on inflammation, and does not increase fibrosis. Rabbit voice muscle shows good tolerance to fascia lata grafting.
publishDate 2011
dc.date.none.fl_str_mv 2011-04-01
2015-06-14T13:43:02Z
2015-06-14T13:43:02Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1808-86942011000200008
Brazilian Journal of Otorhinolaryngology. Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial, v. 77, n. 2, p. 185-190, 2011.
10.1590/S1808-86942011000200008
S1808-86942011000200008-en.pdf
S1808-86942011000200008-pt.pdf
1808-8694
S1808-86942011000200008
http://repositorio.unifesp.br/handle/11600/6421
WOS:000293578500008
url http://dx.doi.org/10.1590/S1808-86942011000200008
http://repositorio.unifesp.br/handle/11600/6421
identifier_str_mv Brazilian Journal of Otorhinolaryngology. Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial, v. 77, n. 2, p. 185-190, 2011.
10.1590/S1808-86942011000200008
S1808-86942011000200008-en.pdf
S1808-86942011000200008-pt.pdf
1808-8694
S1808-86942011000200008
WOS:000293578500008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal of Otorhinolaryngology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 185-190
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial
publisher.none.fl_str_mv Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268275579682816

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