Retinal arterial diameter changes in progressive and nonprogressive glaucoma

• Autor(a) principal: Soares, Adael S. [UNIFESP]
• Data de Publicação: 2003
• Outros Autores: Artes, P. H., McCormick, T. A., LeBlanc, R. P., Nicolela, M. T., Chauhan, B. C.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://repositorio.unifesp.br/handle/11600/27260; http://dx.doi.org/10.1097/00061198-200306000-00011
• topic: glaucoma; progression; retinal arterial diameter

Purpose: To determine if the degree of retinal arterial diameter change is different between patients with progressive and nonprogressive open-angle glaucoma.Material and Methods: in this prospective cohort study, 44 eyes of 44 open-angle glaucoma patients (mean age, 67.5 years; age range, 52-84 years; mean follow-up period, 4.9 years; follow-up range, 1.3-7.5 years) were included. the change in arterial diameter between the baseline and the most recent follow-up optic disc photograph was determined. the diameter of the 4 major arteries was measured at the optic disc margin and at the thinnest and broadest locations within 1 optic disc diameter from the disc margin. Patients were stratified into progressing and nonprogressing groups according to visual field and optic disc criteria.Results: Visual field progression was observed in 13 (30%) patients and optic disc progression in 24 (55%) patients. On average, the arterial diameters at the edge of the optic disc decreased significantly by 2.37% (95% CI, -3.31% to - 1.41%) per year of follow-up (P<0.001). No significant difference in generalized or focal arterial narrowing was observed between progressive and nonprogressive groups regardless of the criterion used (P>0.462). With this sample, the power to detect a 10% difference in arterial narrowing between the 2 groups was 66%. There was no relationship between the rates of visual field progression and arterial diameter change in the whole group (P = 0.171) or in groups segregated into progressing and nonprogressing patients (P>0.104).Conclusion: Arterial diameters decreased in both progressive and nonprogressive glaucoma. in this study, there was little evidence that arterial narrowing was more pronounced in progressive disease.