Enteroaggregative Escherichia coli with uropathogenic characteristics are present in feces of diarrheic and healthy children

• Autor(a) principal: Nunes, Kamila O.
• Data de Publicação: 2017
• Outros Autores: Santos, Adriana C. P., Bando, Silvia Y., Silva, Rosa M. [UNIFESP], Gomes, Tania A. T. [UNIFESP], Elias, Waldir P.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1093/femspd/ftx106; https://repositorio.unifesp.br/handle/11600/58245
• topic: enteroaggregative E. coli; uropathogenic E. coli; virulence factors; phylogeny; bacterial infections

Enteroaggregative Escherichia coli (EAEC) has been recently associated with urinary tract infections (UTI). Since EAEC are found in feces of both diarrheic and asymptomatic individuals, their presence in the intestine may be a source of UTI. In this study, we detected in feces of diarrheic and healthy children a subset of EAEC strains with genetic markers of extraintestinal pathogenic E. coli (ExPEC). MLST grouped these EAEC with ExPEC markers in three main clusters along with prototypes strains of EAEC, uropathogenic E. coli and UTI-causing EAEC. Interestingly, the latter cluster was composed by EAEC with ExPEC markers belonging to phylogroup A and closely related to the uropathogenic EAEC O78:H10 strain. Such attributes suggest that these strains have uropathogenic abilities. Therefore, intestinal carriers of these strains are potentially in risk to develop UTIs.