Incidência de malignidade na doença nodular da tiróide com baixa suspeita clínica: estudo observacional prospectivo por dois anos numa coorte de 50 pacientes

• Autor(a) principal: Yamazaki, Claudia A. [UNIFESP]
• Data de Publicação: 2004
• Outros Autores: Mamone, Maria da Conceição de Oliveira Carneiro [UNIFESP], Ikejiri, Elza Setsuku [UNIFESP], Hidal, Jairo Tabacow [UNIFESP], Matsumura, Luiza Kimiko [UNIFESP], Hojaij, Flávio Carneiro [UNIFESP], Cervantes, Onivaldo [UNIFESP], Abrahão, Márcio [UNIFESP], Furlanetto, Reinaldo Perrone [UNIFESP], Maciel, Rui Monteiro de Barros [UNIFESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S0004-27302004000200012; http://repositorio.unifesp.br/handle/11600/2070
• topic: Thyroid nodule; Thyroid ultrasound; Thyroid cancer; Fine-needle thyroid biopsy; Nódulo de tiróide; Ultra-sonografia de tiróide; Câncer de tiróide; Citologia aspirativa por agulha fina

INTRODUCTION: To study the frequency of malignant lesions in patients with clinically benign thyroid nodules and the value of the repetition of fine needle aspiration biopsy (FNAB). METHODS: Observational and prospective 2-year study in a cohort of 50 patients with clinically benign thyroid nodules. Patients were initially submitted to clinical examination, ultrasound (US) and FNAB1 patients, followed by a second FNAB and US. RESULTS: Palpation is not a good test for diagnosis and follow-up of thyroid nodules. On the other hand, the initial consideration that these patients should harbor benign lesions is a very useful parameter, since 47/50 patients (94%) did not present malignant lesions during the follow-up. FNAB1 and FNAB2 were concordant in 33/39 patients when FNAB1 was negative (85%); 11 patients were operated, 8 by suspicious FNAB and 3 due to nodule growth. We observed 2 patients with non-invasive papillary microcarcinoma and 1 patient with papillary carcinoma outside of the main nodules. CONCLUSION: there was concordance between initial clinical benign diagnosis, FNAB and the follow-up. In one case there was a papillary carcinoma. In addition, ultrasonography should be considered for all patients with suspected thyroid nodules. Finally, we demonstrated that a second cytology usually confirms the result of the first cytology in benign thyroid nodules.