Different patterns of epileptiform-like activity are generated in the sclerotic hippocampus from patients with drug-resistant temporal lobe epilepsy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| Texto Completo: | http://dx.doi.org/10.1038/s41598-018-25378-9 http://repositorio.unifesp.br/handle/11600/46043 |
Resumo: | Human hippocampal slice preparations from patients with temporal lobe epilepsy (TLE) associated with hippocampal sclerosis (HS) are excellent material for the characterization of epileptiform-like activity. However, it is still unknown if hippocampal regions as cornu Ammonis (CA) 1, CA3 and CA4, generate population epileptiform-like activity. Here, we investigated epileptiform activities of the subiculum, CA1, CA2, CA3, CA4 (induced by elevation of extracellular potassium concentration) and the dentate gyrus (induced with hilar stimulation and elevation of potassium concentration) from sclerotic hippocampi of patients with drug-resistant TLE. Five types of epileptiform-like activity were observed: interictal-like events |
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Different patterns of epileptiform-like activity are generated in the sclerotic hippocampus from patients with drug-resistant temporal lobe epilepsyHuman hippocampal slice preparations from patients with temporal lobe epilepsy (TLE) associated with hippocampal sclerosis (HS) are excellent material for the characterization of epileptiform-like activity. However, it is still unknown if hippocampal regions as cornu Ammonis (CA) 1, CA3 and CA4, generate population epileptiform-like activity. Here, we investigated epileptiform activities of the subiculum, CA1, CA2, CA3, CA4 (induced by elevation of extracellular potassium concentration) and the dentate gyrus (induced with hilar stimulation and elevation of potassium concentration) from sclerotic hippocampi of patients with drug-resistant TLE. Five types of epileptiform-like activity were observed: interictal-like eventsperiodic ictal spikingseizure-like eventsspreading depression-like eventstonic seizure-like events and no activity. Different susceptibilities to generate epileptiform activity among hippocampal regions were observedthe dentate gyrus was the most susceptible region followed by the subiculum, CA4, CA1, CA2 and CA3. The incidence of epileptiform activity pattern was associated with specific regions of the hippocampal formation. Moreover, it was observed that each region of the hippocampal formation exhibits frequency-specific ranges in each subfield of the sclerotic human tissue. In conclusion, this study demonstrates that epileptiform-like activity may be induced in different regions of the hippocampal formation, including regions that are severely affected by neuronal loss.Univ Fed Sao Paulo, Dept Neurol & Neurocirurgia, Escola Paulista Med, Sao Paulo, BrazilUniv Nacl Autonoma Honduras, Fac Ciencias Med, Dept Ciencias Morfol, Tegucigalpa, HondurasUniv Fed Sao Paulo, Dept Neurol & Neurocirurgia, Escola Paulista Med, Sao Paulo, BrazilWeb of ScienceFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)FAPESP/CNPq/MCT-Instituto Nacional de Neurociencia TranslacionalUniversidad Nacional Autonoma de HondurasFAPESP: 15/24691-8FAPESP/CNPq/MCT: 573604/2008-8UNAH: CU-O-041-05-2014Nature Publishing Group2018-07-26T12:18:48Z2018-07-26T12:18:48Z2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion-application/pdfhttp://dx.doi.org/10.1038/s41598-018-25378-9Scientific Reports. London, v. 8, p. -, 2018.10.1038/s41598-018-25378-9WOS000431622100020.pdf2045-2322http://repositorio.unifesp.br/handle/11600/46043WOS:000431622100020enginfo:eu-repo/semantics/openAccessReyes-Garcia, Selvin Z. [UNIFESP]Scorza, Carla Alessandra [UNIFESP]Araujo, Noemi S. [UNIFESP]Ortiz-Villatoro, Nancy N. [UNIFESP]Jardim, Anaclara Prada [UNIFESP]Centeno, Ricardo Silva [UNIFESP]Yacubian, Elza Márcia Targas [UNIFESP]Faber, Jean [UNIFESP]Cavalheiro, Esper Abrão [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-03T05:07:42Zoai:repositorio.unifesp.br/:11600/46043Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-03T05:07:42Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Different patterns of epileptiform-like activity are generated in the sclerotic hippocampus from patients with drug-resistant temporal lobe epilepsy |
| title |
Different patterns of epileptiform-like activity are generated in the sclerotic hippocampus from patients with drug-resistant temporal lobe epilepsy |
| spellingShingle |
Different patterns of epileptiform-like activity are generated in the sclerotic hippocampus from patients with drug-resistant temporal lobe epilepsy Reyes-Garcia, Selvin Z. [UNIFESP] |
| title_short |
Different patterns of epileptiform-like activity are generated in the sclerotic hippocampus from patients with drug-resistant temporal lobe epilepsy |
| title_full |
Different patterns of epileptiform-like activity are generated in the sclerotic hippocampus from patients with drug-resistant temporal lobe epilepsy |
| title_fullStr |
Different patterns of epileptiform-like activity are generated in the sclerotic hippocampus from patients with drug-resistant temporal lobe epilepsy |
| title_full_unstemmed |
Different patterns of epileptiform-like activity are generated in the sclerotic hippocampus from patients with drug-resistant temporal lobe epilepsy |
| title_sort |
Different patterns of epileptiform-like activity are generated in the sclerotic hippocampus from patients with drug-resistant temporal lobe epilepsy |
| author |
Reyes-Garcia, Selvin Z. [UNIFESP] |
| author_facet |
Reyes-Garcia, Selvin Z. [UNIFESP] Scorza, Carla Alessandra [UNIFESP] Araujo, Noemi S. [UNIFESP] Ortiz-Villatoro, Nancy N. [UNIFESP] Jardim, Anaclara Prada [UNIFESP] Centeno, Ricardo Silva [UNIFESP] Yacubian, Elza Márcia Targas [UNIFESP] Faber, Jean [UNIFESP] Cavalheiro, Esper Abrão [UNIFESP] |
| author_role |
author |
| author2 |
Scorza, Carla Alessandra [UNIFESP] Araujo, Noemi S. [UNIFESP] Ortiz-Villatoro, Nancy N. [UNIFESP] Jardim, Anaclara Prada [UNIFESP] Centeno, Ricardo Silva [UNIFESP] Yacubian, Elza Márcia Targas [UNIFESP] Faber, Jean [UNIFESP] Cavalheiro, Esper Abrão [UNIFESP] |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Reyes-Garcia, Selvin Z. [UNIFESP] Scorza, Carla Alessandra [UNIFESP] Araujo, Noemi S. [UNIFESP] Ortiz-Villatoro, Nancy N. [UNIFESP] Jardim, Anaclara Prada [UNIFESP] Centeno, Ricardo Silva [UNIFESP] Yacubian, Elza Márcia Targas [UNIFESP] Faber, Jean [UNIFESP] Cavalheiro, Esper Abrão [UNIFESP] |
| description |
Human hippocampal slice preparations from patients with temporal lobe epilepsy (TLE) associated with hippocampal sclerosis (HS) are excellent material for the characterization of epileptiform-like activity. However, it is still unknown if hippocampal regions as cornu Ammonis (CA) 1, CA3 and CA4, generate population epileptiform-like activity. Here, we investigated epileptiform activities of the subiculum, CA1, CA2, CA3, CA4 (induced by elevation of extracellular potassium concentration) and the dentate gyrus (induced with hilar stimulation and elevation of potassium concentration) from sclerotic hippocampi of patients with drug-resistant TLE. Five types of epileptiform-like activity were observed: interictal-like events |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018-07-26T12:18:48Z 2018-07-26T12:18:48Z 2018 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1038/s41598-018-25378-9 Scientific Reports. London, v. 8, p. -, 2018. 10.1038/s41598-018-25378-9 WOS000431622100020.pdf 2045-2322 http://repositorio.unifesp.br/handle/11600/46043 WOS:000431622100020 |
| url |
http://dx.doi.org/10.1038/s41598-018-25378-9 http://repositorio.unifesp.br/handle/11600/46043 |
| identifier_str_mv |
Scientific Reports. London, v. 8, p. -, 2018. 10.1038/s41598-018-25378-9 WOS000431622100020.pdf 2045-2322 WOS:000431622100020 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
- application/pdf |
| dc.publisher.none.fl_str_mv |
Nature Publishing Group |
| publisher.none.fl_str_mv |
Nature Publishing Group |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| instname_str |
Universidade Federal de São Paulo (UNIFESP) |
| instacron_str |
UNIFESP |
| institution |
UNIFESP |
| reponame_str |
Repositório Institucional da UNIFESP |
| collection |
Repositório Institucional da UNIFESP |
| repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
| repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1814268335376826368 |