Efeitos da associação de benfotiamina e ácido alfa-lipóico no tratamento de doença hepática alcoólica em modelo experimental

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Autor(a) principal: SOUZA, Maiara Laís de
Data de Publicação: 2018
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFTM
Texto Completo: http://bdtd.uftm.edu.br/handle/tede/657
Resumo: Introdução: A doença hepática alcoólica (ALD) é resultante do consumo abusivo de álcool e sua evolução é resultado do estresse oxidativo desenvolvido por esta ingestão de etanol e seu metabolismo. A possibilidade do uso combinado de antioxidantes merece uma investigação mais profunda a fim de encontrar mais dados sobre sua utilização combinada. Objetivos: Avaliar a associação da benfotiamina (BT) com o ácido alfa lipóico (ALA) como tratamento aos danos hepáticos provocados pela ingestão crônica de etanol em modelo experimental. Material e Métodos: foram utilizados 32 ratos Wistar machos recém desmamados foram submetidos ao protocolo para o desenvolvimento de ALD e após 30 dias foram divididos em 4 grupos e receberam suplementação antioxidante por 14 dias: E (etanol), EA (etanol + ALA), EB (etanol + BT), EAB (etanol + ALA + BT). Ao fim do experimento, os animais foram eutanasiados e foi coletado o fígado para análise. Resultados: Não houve diferença entre consumo e evolução ponderal entre os grupos. Também não houve diferença em relação à concentração de tiós não-proteícos e atividade enzimática da superóxido dismutase e catalase. A concentração de vitamina E foi maior no grupo suplementado com ácido alfa lipóico, e o malondialdeído teve menor concentração no grupo EAB. Conclusão: Os resultados do presente estudo permitem concluir que a suplementação combinada de dois antioxidantes pode trazer benefícios através da influência, exercida sobre componentes do sistema de defesa antioxidante não-enzimático, assim como sua ação direta através da doação de hidrogênio a espécies radicalares. Para elucidar esta questão, mais estudos futuros são necessários.
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spelling Efeitos da associação de benfotiamina e ácido alfa-lipóico no tratamento de doença hepática alcoólica em modelo experimentalDoença Hepática Alcoólica.Estresse Oxidativo.Antioxidantes.Alcoholic Liver Disease.Oxidative stress.Antioxidants.Metabolismo e BioenergéticaIntrodução: A doença hepática alcoólica (ALD) é resultante do consumo abusivo de álcool e sua evolução é resultado do estresse oxidativo desenvolvido por esta ingestão de etanol e seu metabolismo. A possibilidade do uso combinado de antioxidantes merece uma investigação mais profunda a fim de encontrar mais dados sobre sua utilização combinada. Objetivos: Avaliar a associação da benfotiamina (BT) com o ácido alfa lipóico (ALA) como tratamento aos danos hepáticos provocados pela ingestão crônica de etanol em modelo experimental. Material e Métodos: foram utilizados 32 ratos Wistar machos recém desmamados foram submetidos ao protocolo para o desenvolvimento de ALD e após 30 dias foram divididos em 4 grupos e receberam suplementação antioxidante por 14 dias: E (etanol), EA (etanol + ALA), EB (etanol + BT), EAB (etanol + ALA + BT). Ao fim do experimento, os animais foram eutanasiados e foi coletado o fígado para análise. Resultados: Não houve diferença entre consumo e evolução ponderal entre os grupos. Também não houve diferença em relação à concentração de tiós não-proteícos e atividade enzimática da superóxido dismutase e catalase. A concentração de vitamina E foi maior no grupo suplementado com ácido alfa lipóico, e o malondialdeído teve menor concentração no grupo EAB. Conclusão: Os resultados do presente estudo permitem concluir que a suplementação combinada de dois antioxidantes pode trazer benefícios através da influência, exercida sobre componentes do sistema de defesa antioxidante não-enzimático, assim como sua ação direta através da doação de hidrogênio a espécies radicalares. Para elucidar esta questão, mais estudos futuros são necessários.Introduction: Alcoholic liver disease (ALD) is a result of alcohol abuse and its evolution is a result of the oxidative stress developed by this ethanol intake and its metabolism. The possibility of the combined use of antioxidants merits further investigation in order to find more conclusive data on their combined use. Objectives: To evaluate the association between benfotiamine (BT) and alpha lipoic acid (ALA) as a treatment for liver damage caused by chronic ethanol ingestion in an experimental model. Material and methods: Thirty-two male Wistar rats, 60-90g, after a period of adjustment and adaptation to the liquid diet, and were submitted to protocol for the development of ALD and after 30 days were divided into 4 groups: E (ethanol) , EA (ethanol + alpha-lipoic acid), EB (ethanol + benfotiamine), EAB (ethanol + alpha-lipoic acid + benfotiamine) and received antioxidant supplementation for 14 days as a treatment. At the end of the experiment, the animals were euthanized and the liver were collected for analysis. Results: There was no difference between consumption and weight evolution between the groups. There was also no statistically significant difference in relation to the concentration of non-protein thiols and the enzymatic activity of superoxide dismutase and catalase. The concentration of vitamin E was higher in the group supplemented with alpha lipoic acid, and malondialdehyde had a lower concentration in the EAB group. Conclusion: The results of the present study allow to conclude that the combined supplementation of two antioxidants can bring benefits through the influence exerted on components of the non-enzymatic antioxidant defense system as well as its direct action through the hydrogen donation to radical species. To elucidate this issue, more future studies are needed.Universidade Federal do Triângulo MineiroInstituto de Ciências da Saúde - ICS::Programa de Pós-Graduação em Ciências da SaúdeBrasilUFTMPrograma de Pós-Graduação em Ciências da SaúdePORTARIA, Guilherme Vannucchi26157082879http://lattes.cnpq.br/6076945534196087SOUZA, Maiara Laís de2019-05-21T12:58:02Z2018-06-25info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfapplication/pdfSOUZA, Maiara Laís de. Efeitos da associação de benfotiamina e ácido alfa-lipóico no tratamento de doença hepática alcoólica em modelo experimental. 2018. 64f. 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dc.title.none.fl_str_mv Efeitos da associação de benfotiamina e ácido alfa-lipóico no tratamento de doença hepática alcoólica em modelo experimental
title Efeitos da associação de benfotiamina e ácido alfa-lipóico no tratamento de doença hepática alcoólica em modelo experimental
spellingShingle Efeitos da associação de benfotiamina e ácido alfa-lipóico no tratamento de doença hepática alcoólica em modelo experimental
SOUZA, Maiara Laís de
Doença Hepática Alcoólica.
Estresse Oxidativo.
Antioxidantes.
Alcoholic Liver Disease.
Oxidative stress.
Antioxidants.
Metabolismo e Bioenergética
title_short Efeitos da associação de benfotiamina e ácido alfa-lipóico no tratamento de doença hepática alcoólica em modelo experimental
title_full Efeitos da associação de benfotiamina e ácido alfa-lipóico no tratamento de doença hepática alcoólica em modelo experimental
title_fullStr Efeitos da associação de benfotiamina e ácido alfa-lipóico no tratamento de doença hepática alcoólica em modelo experimental
title_full_unstemmed Efeitos da associação de benfotiamina e ácido alfa-lipóico no tratamento de doença hepática alcoólica em modelo experimental
title_sort Efeitos da associação de benfotiamina e ácido alfa-lipóico no tratamento de doença hepática alcoólica em modelo experimental
author SOUZA, Maiara Laís de
author_facet SOUZA, Maiara Laís de
author_role author
dc.contributor.none.fl_str_mv PORTARIA, Guilherme Vannucchi
26157082879
http://lattes.cnpq.br/6076945534196087
dc.contributor.author.fl_str_mv SOUZA, Maiara Laís de
dc.subject.por.fl_str_mv Doença Hepática Alcoólica.
Estresse Oxidativo.
Antioxidantes.
Alcoholic Liver Disease.
Oxidative stress.
Antioxidants.
Metabolismo e Bioenergética
topic Doença Hepática Alcoólica.
Estresse Oxidativo.
Antioxidantes.
Alcoholic Liver Disease.
Oxidative stress.
Antioxidants.
Metabolismo e Bioenergética
description Introdução: A doença hepática alcoólica (ALD) é resultante do consumo abusivo de álcool e sua evolução é resultado do estresse oxidativo desenvolvido por esta ingestão de etanol e seu metabolismo. A possibilidade do uso combinado de antioxidantes merece uma investigação mais profunda a fim de encontrar mais dados sobre sua utilização combinada. Objetivos: Avaliar a associação da benfotiamina (BT) com o ácido alfa lipóico (ALA) como tratamento aos danos hepáticos provocados pela ingestão crônica de etanol em modelo experimental. Material e Métodos: foram utilizados 32 ratos Wistar machos recém desmamados foram submetidos ao protocolo para o desenvolvimento de ALD e após 30 dias foram divididos em 4 grupos e receberam suplementação antioxidante por 14 dias: E (etanol), EA (etanol + ALA), EB (etanol + BT), EAB (etanol + ALA + BT). Ao fim do experimento, os animais foram eutanasiados e foi coletado o fígado para análise. Resultados: Não houve diferença entre consumo e evolução ponderal entre os grupos. Também não houve diferença em relação à concentração de tiós não-proteícos e atividade enzimática da superóxido dismutase e catalase. A concentração de vitamina E foi maior no grupo suplementado com ácido alfa lipóico, e o malondialdeído teve menor concentração no grupo EAB. Conclusão: Os resultados do presente estudo permitem concluir que a suplementação combinada de dois antioxidantes pode trazer benefícios através da influência, exercida sobre componentes do sistema de defesa antioxidante não-enzimático, assim como sua ação direta através da doação de hidrogênio a espécies radicalares. Para elucidar esta questão, mais estudos futuros são necessários.
publishDate 2018
dc.date.none.fl_str_mv 2018-06-25
2019-05-21T12:58:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv SOUZA, Maiara Laís de. Efeitos da associação de benfotiamina e ácido alfa-lipóico no tratamento de doença hepática alcoólica em modelo experimental. 2018. 64f. Dissertação (Mestrado em Ciências da Saúde) - Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Triângulo Mineiro, Uberaba, 2018.
http://bdtd.uftm.edu.br/handle/tede/657
identifier_str_mv SOUZA, Maiara Laís de. Efeitos da associação de benfotiamina e ácido alfa-lipóico no tratamento de doença hepática alcoólica em modelo experimental. 2018. 64f. Dissertação (Mestrado em Ciências da Saúde) - Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Triângulo Mineiro, Uberaba, 2018.
url http://bdtd.uftm.edu.br/handle/tede/657
dc.language.iso.fl_str_mv por
language por
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dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Universidade Federal do Triângulo Mineiro
Instituto de Ciências da Saúde - ICS::Programa de Pós-Graduação em Ciências da Saúde
Brasil
UFTM
Programa de Pós-Graduação em Ciências da Saúde
publisher.none.fl_str_mv Universidade Federal do Triângulo Mineiro
Instituto de Ciências da Saúde - ICS::Programa de Pós-Graduação em Ciências da Saúde
Brasil
UFTM
Programa de Pós-Graduação em Ciências da Saúde
dc.source.none.fl_str_mv reponame:Biblioteca Digital de Teses e Dissertações da UFTM
instname:Universidade Federal do Triangulo Mineiro (UFTM)
instacron:UFTM
instname_str Universidade Federal do Triangulo Mineiro (UFTM)
instacron_str UFTM
institution UFTM
reponame_str Biblioteca Digital de Teses e Dissertações da UFTM
collection Biblioteca Digital de Teses e Dissertações da UFTM
repository.name.fl_str_mv Biblioteca Digital de Teses e Dissertações da UFTM - Universidade Federal do Triangulo Mineiro (UFTM)
repository.mail.fl_str_mv bdtd@uftm.edu.br||bdtd@uftm.edu.br
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