Prevalence of oral injuries and salivary changes in patients with chronic renal failure on hemodialysis: systematic review and meta-analysis

Detalhes bibliográficos
Autor(a) principal: dos Santos, Vanessa Cardoso
Data de Publicação: 2023
Outros Autores: Gambin, Diego José, Casanova, Keli Adriana Silvestre, Vitali, Filipe Colombo, Dogenski, Letícia Copatti, Duque, Thais Mageste, Trentin, Micheline Sandini, João Paulo De Carli
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Bioscience journal (Online)
Texto Completo: https://seer.ufu.br/index.php/biosciencejournal/article/view/63061
Resumo: The objective of this study was to evaluate whether individuals with chronic renal failure (CRF) undergoing hemodialysis treatment have more salivary and oral mucosa alterations when compared to healthy individuals, through a systematic review followed by meta-analysis. A systematic literature review was performed, evaluating randomized clinical trials found in the Proquest, Embase, Scopus, Cochrane Library, Web of Science, Lilacs and Pubmed databases, using MeSH terms and other keywords. Initially, 40 articles were included in the study and, after reading the complete articles, only 15 clinical trials that analyzed oral lesions and salivary changes in patients with CRF undergoing hemodialysis treatment were eligible. Most of the clinical studies included were cross-sectional and composed of a study group and a control group. The mean age of participants in the study group was 50.19 years and in the control group, 48.95 years. The most common oral alterations found in the CRF group in relation to the control group were xerostomia, uremic breath, dysgeusia, coated tongue, gingival bleeding and pale mucosa. The salivary flow of patients with CRF was 46.6% lower than the control group. The salivary pH in the study group was also more alkaline when compared to the control group. Greater amounts of urea, phosphate, C-reactive protein and total proteins were found in the saliva of individuals with CRF. Individuals with CRF undergoing hemodialysis are more prone to changes in both the quantity and quality of saliva, as well as having a greater amount of oral changes.
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spelling Prevalence of oral injuries and salivary changes in patients with chronic renal failure on hemodialysis: systematic review and meta-analysisPrevalência de alterações orais e salivares em pacientes com falha renal crônica em hemodiálise: Revisão sistemática e metanáliseChronic Renal FailureSalivary pHHyposalivationSalivary ChangesXerostomia. Health SciencesThe objective of this study was to evaluate whether individuals with chronic renal failure (CRF) undergoing hemodialysis treatment have more salivary and oral mucosa alterations when compared to healthy individuals, through a systematic review followed by meta-analysis. A systematic literature review was performed, evaluating randomized clinical trials found in the Proquest, Embase, Scopus, Cochrane Library, Web of Science, Lilacs and Pubmed databases, using MeSH terms and other keywords. Initially, 40 articles were included in the study and, after reading the complete articles, only 15 clinical trials that analyzed oral lesions and salivary changes in patients with CRF undergoing hemodialysis treatment were eligible. Most of the clinical studies included were cross-sectional and composed of a study group and a control group. The mean age of participants in the study group was 50.19 years and in the control group, 48.95 years. The most common oral alterations found in the CRF group in relation to the control group were xerostomia, uremic breath, dysgeusia, coated tongue, gingival bleeding and pale mucosa. The salivary flow of patients with CRF was 46.6% lower than the control group. The salivary pH in the study group was also more alkaline when compared to the control group. Greater amounts of urea, phosphate, C-reactive protein and total proteins were found in the saliva of individuals with CRF. Individuals with CRF undergoing hemodialysis are more prone to changes in both the quantity and quality of saliva, as well as having a greater amount of oral changes.O objetivo deste trabalho foi avaliar, por meio de revisão sistemática seguida de metanálise, se indivíduos com insuficiência renal crônica (IRC) associada a hemodiálise apresentam alterações salivares e da mucosa oral quando comparados a indivíduos saudáveis. Foi realizada uma revisão sistemática da literatura, avaliando ensaios clínicos randomizados encontrados nas bases de dados Proquest, Embase, Scopus, Cochrane Library, Web of Science, Lilacs e Pubmed, utilizando termos MeSH e outras palavras-chave. Inicialmente, 40 artigos foram incluídos no estudo e, após a leitura dos artigos completos, foram elegíveis 15 ensaios clínicos que analisaram lesões orais e alterações salivares em pacientes com IRC incluindo tratamento hemodialítico. A maioria dos estudos clínicos incluídos foi transversal e composta por um grupo de estudo e um grupo controle. A média de idade dos participantes do grupo de estudo foi de 50,19 anos e do grupo controle de 48,95 anos. As alterações orais mais comuns encontradas no grupo IRC em relação ao grupo controle foram: xerostomia, hálito urêmico, disgeusia, língua saburrosa, sangramento gengival e mucosa pálida. O fluxo salivar dos pacientes com IRC foi 46,6% menor que o do grupo controle. O pH salivar do grupo de estudo também foi mais alcalino quando comparado ao grupo controle. Maiores quantidades de ureia, fosfato, proteína C reativa e proteínas totais foram encontradas na saliva de indivíduos com IRC. Indivíduos com IRC em hemodiálise estão mais sujeitos a alterações tanto na quantidade quanto na qualidade da saliva, além de apresentarem maior quantidade de alterações orais.Universidade Federal de Uberlândia2023-01-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://seer.ufu.br/index.php/biosciencejournal/article/view/6306110.14393/BJ-v39n0a2023-63061Bioscience Journal ; Vol. 39 (2023): Continuous Publication; e39013Bioscience Journal ; v. 39 (2023): Continuous Publication; e390131981-3163reponame:Bioscience journal (Online)instname:Universidade Federal de Uberlândia (UFU)instacron:UFUenghttps://seer.ufu.br/index.php/biosciencejournal/article/view/63061/35494Brazil; Contemporary Copyright (c) 2023 Vanessa Cardoso dos Santos, Diego José Gambin, Keli Adriana Silvestre Casanova, Filipe Colombo Vitali, Letícia Copatti Dogenski, Thais Mageste Duque, Micheline Sandini Trentin, João Paulo De Carlihttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessdos Santos, Vanessa CardosoGambin, Diego JoséCasanova, Keli Adriana SilvestreVitali, Filipe ColomboDogenski, Letícia CopattiDuque, Thais MagesteTrentin, Micheline SandiniJoão Paulo De Carli2024-01-31T19:16:18Zoai:ojs.www.seer.ufu.br:article/63061Revistahttps://seer.ufu.br/index.php/biosciencejournalPUBhttps://seer.ufu.br/index.php/biosciencejournal/oaibiosciencej@ufu.br||1981-31631516-3725opendoar:2024-01-31T19:16:18Bioscience journal (Online) - Universidade Federal de Uberlândia (UFU)false
dc.title.none.fl_str_mv Prevalence of oral injuries and salivary changes in patients with chronic renal failure on hemodialysis: systematic review and meta-analysis
Prevalência de alterações orais e salivares em pacientes com falha renal crônica em hemodiálise: Revisão sistemática e metanálise
title Prevalence of oral injuries and salivary changes in patients with chronic renal failure on hemodialysis: systematic review and meta-analysis
spellingShingle Prevalence of oral injuries and salivary changes in patients with chronic renal failure on hemodialysis: systematic review and meta-analysis
dos Santos, Vanessa Cardoso
Chronic Renal Failure
Salivary pH
Hyposalivation
Salivary Changes
Xerostomia.
Health Sciences
title_short Prevalence of oral injuries and salivary changes in patients with chronic renal failure on hemodialysis: systematic review and meta-analysis
title_full Prevalence of oral injuries and salivary changes in patients with chronic renal failure on hemodialysis: systematic review and meta-analysis
title_fullStr Prevalence of oral injuries and salivary changes in patients with chronic renal failure on hemodialysis: systematic review and meta-analysis
title_full_unstemmed Prevalence of oral injuries and salivary changes in patients with chronic renal failure on hemodialysis: systematic review and meta-analysis
title_sort Prevalence of oral injuries and salivary changes in patients with chronic renal failure on hemodialysis: systematic review and meta-analysis
author dos Santos, Vanessa Cardoso
author_facet dos Santos, Vanessa Cardoso
Gambin, Diego José
Casanova, Keli Adriana Silvestre
Vitali, Filipe Colombo
Dogenski, Letícia Copatti
Duque, Thais Mageste
Trentin, Micheline Sandini
João Paulo De Carli
author_role author
author2 Gambin, Diego José
Casanova, Keli Adriana Silvestre
Vitali, Filipe Colombo
Dogenski, Letícia Copatti
Duque, Thais Mageste
Trentin, Micheline Sandini
João Paulo De Carli
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv dos Santos, Vanessa Cardoso
Gambin, Diego José
Casanova, Keli Adriana Silvestre
Vitali, Filipe Colombo
Dogenski, Letícia Copatti
Duque, Thais Mageste
Trentin, Micheline Sandini
João Paulo De Carli
dc.subject.por.fl_str_mv Chronic Renal Failure
Salivary pH
Hyposalivation
Salivary Changes
Xerostomia.
Health Sciences
topic Chronic Renal Failure
Salivary pH
Hyposalivation
Salivary Changes
Xerostomia.
Health Sciences
description The objective of this study was to evaluate whether individuals with chronic renal failure (CRF) undergoing hemodialysis treatment have more salivary and oral mucosa alterations when compared to healthy individuals, through a systematic review followed by meta-analysis. A systematic literature review was performed, evaluating randomized clinical trials found in the Proquest, Embase, Scopus, Cochrane Library, Web of Science, Lilacs and Pubmed databases, using MeSH terms and other keywords. Initially, 40 articles were included in the study and, after reading the complete articles, only 15 clinical trials that analyzed oral lesions and salivary changes in patients with CRF undergoing hemodialysis treatment were eligible. Most of the clinical studies included were cross-sectional and composed of a study group and a control group. The mean age of participants in the study group was 50.19 years and in the control group, 48.95 years. The most common oral alterations found in the CRF group in relation to the control group were xerostomia, uremic breath, dysgeusia, coated tongue, gingival bleeding and pale mucosa. The salivary flow of patients with CRF was 46.6% lower than the control group. The salivary pH in the study group was also more alkaline when compared to the control group. Greater amounts of urea, phosphate, C-reactive protein and total proteins were found in the saliva of individuals with CRF. Individuals with CRF undergoing hemodialysis are more prone to changes in both the quantity and quality of saliva, as well as having a greater amount of oral changes.
publishDate 2023
dc.date.none.fl_str_mv 2023-01-20
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://seer.ufu.br/index.php/biosciencejournal/article/view/63061
10.14393/BJ-v39n0a2023-63061
url https://seer.ufu.br/index.php/biosciencejournal/article/view/63061
identifier_str_mv 10.14393/BJ-v39n0a2023-63061
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://seer.ufu.br/index.php/biosciencejournal/article/view/63061/35494
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.coverage.none.fl_str_mv Brazil; Contemporary
dc.publisher.none.fl_str_mv Universidade Federal de Uberlândia
publisher.none.fl_str_mv Universidade Federal de Uberlândia
dc.source.none.fl_str_mv Bioscience Journal ; Vol. 39 (2023): Continuous Publication; e39013
Bioscience Journal ; v. 39 (2023): Continuous Publication; e39013
1981-3163
reponame:Bioscience journal (Online)
instname:Universidade Federal de Uberlândia (UFU)
instacron:UFU
instname_str Universidade Federal de Uberlândia (UFU)
instacron_str UFU
institution UFU
reponame_str Bioscience journal (Online)
collection Bioscience journal (Online)
repository.name.fl_str_mv Bioscience journal (Online) - Universidade Federal de Uberlândia (UFU)
repository.mail.fl_str_mv biosciencej@ufu.br||
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