Nutritional profile and biochemical alterations in non-institutionalized senior citizens with Alzheimer disease: a case-control study

Detalhes bibliográficos
Autor(a) principal: Pelazza, Bruno Bordin
Data de Publicação: 2020
Outros Autores: Rosa, Patrícia Amâncio da, Borges, Loriane Francisca Tarnopolski, Parizotto, Caroline, Verbaneck, Jéssica Duarte, Silva, Dannyele Cristina da, Mendonca, Guilherme Silva, Silva, Weber Cláudio Francisco Nunes da, Bonini, Juliana Sartori
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Bioscience journal (Online)
Texto Completo: https://seer.ufu.br/index.php/biosciencejournal/article/view/49979
Resumo: Assess the nutritional and biochemical state of patients with Alzheimer Disease (AD) compared to a control group. This is an observational, case-control and descriptive type study, based on the recruiting of 22 elderly individuals with a clinical diagnosis of AD considered as the case group, and 22 other elderly individuals considered as the control group. Evaluations were made using the results from the following scales Mini Nutritional Assessment (MNA), Mini Mental State Examination (MMSE), anthropometric measurements for obtaining the body mass index (BMI) and biochemical analyses. The analyses were performed on the program SPSS version 20.0, using absolute and relative measures, T test for independent samples for measurement comparisons and the Spearman correlation test. In the cognitive evaluation MMSE, those participants with AD present higher risk of cognitive decline (81.8%), greater risk of malnutrition according to MNA (45.5%) and altered levels of leptin (90.9%). Upon performing the comparison analysis between the group with AD and the control group, there existed noteworthy differences between the means for the variables MNA (4.40; BMI95% 2.75 – 6.06), MMSE (10.54; BMI95% 7.09 – 13.99) and doses of HDL (High Density Lipoproteins) (14.53; BMI95% 6.18 – 22.88). As well as differences in the p-value < 0.09 in the leptin doses (11.54; BMI95% (-24.98 – 1.89) and transferrin dose (-72.31; BMI95% -159.48 – 14.84). The Spearman correlation demonstrated that the cognitive decline in the group of senior citizens with AD was strongly associated with nutritional conditions MNA (R 0.484) and the leptin dose (R 0.590). Senior citizens with AD present worse nutritional conditions, cognitive decline and biochemical alterations when compared to senior citizens in the control group. As such, the study demonstrated the need for an integrated healthcare assistance concerning senior citizens with AD. 
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spelling Nutritional profile and biochemical alterations in non-institutionalized senior citizens with Alzheimer disease: a case-control studyPerfil nutricional e alterações bioquimicas em idosos com doença de Alzheimer não institucionalizados: um estudo caso-controleNutritional Assessment.Biomarkers.Mental state assessment.Dementia. Leptin.Health SciencesAvaliação Nutricional.Biomarcadores.Teste de estado mental.Demência. Leptina.Assess the nutritional and biochemical state of patients with Alzheimer Disease (AD) compared to a control group. This is an observational, case-control and descriptive type study, based on the recruiting of 22 elderly individuals with a clinical diagnosis of AD considered as the case group, and 22 other elderly individuals considered as the control group. Evaluations were made using the results from the following scales Mini Nutritional Assessment (MNA), Mini Mental State Examination (MMSE), anthropometric measurements for obtaining the body mass index (BMI) and biochemical analyses. The analyses were performed on the program SPSS version 20.0, using absolute and relative measures, T test for independent samples for measurement comparisons and the Spearman correlation test. In the cognitive evaluation MMSE, those participants with AD present higher risk of cognitive decline (81.8%), greater risk of malnutrition according to MNA (45.5%) and altered levels of leptin (90.9%). Upon performing the comparison analysis between the group with AD and the control group, there existed noteworthy differences between the means for the variables MNA (4.40; BMI95% 2.75 – 6.06), MMSE (10.54; BMI95% 7.09 – 13.99) and doses of HDL (High Density Lipoproteins) (14.53; BMI95% 6.18 – 22.88). As well as differences in the p-value < 0.09 in the leptin doses (11.54; BMI95% (-24.98 – 1.89) and transferrin dose (-72.31; BMI95% -159.48 – 14.84). The Spearman correlation demonstrated that the cognitive decline in the group of senior citizens with AD was strongly associated with nutritional conditions MNA (R 0.484) and the leptin dose (R 0.590). Senior citizens with AD present worse nutritional conditions, cognitive decline and biochemical alterations when compared to senior citizens in the control group. As such, the study demonstrated the need for an integrated healthcare assistance concerning senior citizens with AD. Avaliar o estado nutricional e bioquímico de pacientes com Doença de Alzheimer (DA) comparando com um grupo controle. Materiais e métodos: trata-se de um tipo observacional, caso-controle e descritivo a partir do recrutamento de 22 idosos diagnosticados clinicamente com DA considerados grupo caso e outros 22 idosos considerados controle, foi utilizado a escala Mini Avaliação nutricional (MNA), Mini Exame do Estado Mental (MMSE), medidas antropométricas para obtenção do índice de massa corporal (IMC) e análises bioquímicas. As análises foram realizadas no programa SPSS versão 20.0, utilizou-se de medidas absolutas e relativas, teste T para amostras independentes para comparação de médias e o teste de correlação de Spearman. Na avaliação cognitiva MMSE os participantes com DA apresentaram maior prevalência de declínio cognitivo (81,8%), maior prevalência de risco para desnutrição segundo MNA (45,5%) e níveis alterados de leptina (90,9%). Ao se realizar a análise de comparação o grupo com DA e o controle observou-se diferenças significativas entre as médias das variáveis MNA (4,40; IC95% 2,75 – 6,06), MMSE (10,54; IC95% 7,09 – 13,99) e dosagens de HDL (14,53; IC95% 6,18 – 22,88). E diferenças com o p-valor < 0,09 nas dosagens de leptina (11,54; IC95% (-24,98 – 1,89) e dosagem de transferrina (-72,31; IC95% -159,48 – 14,84). A correlação de Spearman demonstrou que o declínio cognitivo no grupo de idosos com DA, esteve associado significativamente às condições nutricionais MNA (R 0,484) e dosagem de leptina (R 0,590). Idosos com DA apresentaram piores condições nutricionais, declínio cognitivo e alterações bioquímicas, ao compara-los com idosos controles. Desta forma, o estudo demonstra a necessidade de uma assistência integral a esses idososEDUFU2020-12-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://seer.ufu.br/index.php/biosciencejournal/article/view/4997910.14393/BJ-v36n6a2020-49979Bioscience Journal ; Vol. 36 No. 6 (2020): Nov./Dec.; 2315-2329Bioscience Journal ; v. 36 n. 6 (2020): Nov./Dec.; 2315-23291981-3163reponame:Bioscience journal (Online)instname:Universidade Federal de Uberlândia (UFU)instacron:UFUenghttps://seer.ufu.br/index.php/biosciencejournal/article/view/49979/30500Brazil; Contemporary Copyright (c) 2020 Bruno Bordin Pelazza, Patrícia Amâncio da Rosa, Loriane Francisca Tarnopolski Borges, Caroline Parizotto, Jéssica Duarte Verbaneck, Dannyele Cristina da Silva, Guilherme Silva Mendonca, Weber Cláudio Francisco Nunes da Silva, Juliana Sartori Boninihttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessPelazza, Bruno Bordin Rosa, Patrícia Amâncio da Borges, Loriane Francisca Tarnopolski Parizotto, Caroline Verbaneck, Jéssica Duarte Silva, Dannyele Cristina daMendonca, Guilherme SilvaSilva, Weber Cláudio Francisco Nunes da Bonini, Juliana Sartori 2022-06-10T13:00:49Zoai:ojs.www.seer.ufu.br:article/49979Revistahttps://seer.ufu.br/index.php/biosciencejournalPUBhttps://seer.ufu.br/index.php/biosciencejournal/oaibiosciencej@ufu.br||1981-31631516-3725opendoar:2022-06-10T13:00:49Bioscience journal (Online) - Universidade Federal de Uberlândia (UFU)false
dc.title.none.fl_str_mv Nutritional profile and biochemical alterations in non-institutionalized senior citizens with Alzheimer disease: a case-control study
Perfil nutricional e alterações bioquimicas em idosos com doença de Alzheimer não institucionalizados: um estudo caso-controle
title Nutritional profile and biochemical alterations in non-institutionalized senior citizens with Alzheimer disease: a case-control study
spellingShingle Nutritional profile and biochemical alterations in non-institutionalized senior citizens with Alzheimer disease: a case-control study
Pelazza, Bruno Bordin
Nutritional Assessment.
Biomarkers.
Mental state assessment.
Dementia. Leptin.
Health Sciences
Avaliação Nutricional.
Biomarcadores.
Teste de estado mental.
Demência. Leptina.
title_short Nutritional profile and biochemical alterations in non-institutionalized senior citizens with Alzheimer disease: a case-control study
title_full Nutritional profile and biochemical alterations in non-institutionalized senior citizens with Alzheimer disease: a case-control study
title_fullStr Nutritional profile and biochemical alterations in non-institutionalized senior citizens with Alzheimer disease: a case-control study
title_full_unstemmed Nutritional profile and biochemical alterations in non-institutionalized senior citizens with Alzheimer disease: a case-control study
title_sort Nutritional profile and biochemical alterations in non-institutionalized senior citizens with Alzheimer disease: a case-control study
author Pelazza, Bruno Bordin
author_facet Pelazza, Bruno Bordin
Rosa, Patrícia Amâncio da
Borges, Loriane Francisca Tarnopolski
Parizotto, Caroline
Verbaneck, Jéssica Duarte
Silva, Dannyele Cristina da
Mendonca, Guilherme Silva
Silva, Weber Cláudio Francisco Nunes da
Bonini, Juliana Sartori
author_role author
author2 Rosa, Patrícia Amâncio da
Borges, Loriane Francisca Tarnopolski
Parizotto, Caroline
Verbaneck, Jéssica Duarte
Silva, Dannyele Cristina da
Mendonca, Guilherme Silva
Silva, Weber Cláudio Francisco Nunes da
Bonini, Juliana Sartori
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pelazza, Bruno Bordin
Rosa, Patrícia Amâncio da
Borges, Loriane Francisca Tarnopolski
Parizotto, Caroline
Verbaneck, Jéssica Duarte
Silva, Dannyele Cristina da
Mendonca, Guilherme Silva
Silva, Weber Cláudio Francisco Nunes da
Bonini, Juliana Sartori
dc.subject.por.fl_str_mv Nutritional Assessment.
Biomarkers.
Mental state assessment.
Dementia. Leptin.
Health Sciences
Avaliação Nutricional.
Biomarcadores.
Teste de estado mental.
Demência. Leptina.
topic Nutritional Assessment.
Biomarkers.
Mental state assessment.
Dementia. Leptin.
Health Sciences
Avaliação Nutricional.
Biomarcadores.
Teste de estado mental.
Demência. Leptina.
description Assess the nutritional and biochemical state of patients with Alzheimer Disease (AD) compared to a control group. This is an observational, case-control and descriptive type study, based on the recruiting of 22 elderly individuals with a clinical diagnosis of AD considered as the case group, and 22 other elderly individuals considered as the control group. Evaluations were made using the results from the following scales Mini Nutritional Assessment (MNA), Mini Mental State Examination (MMSE), anthropometric measurements for obtaining the body mass index (BMI) and biochemical analyses. The analyses were performed on the program SPSS version 20.0, using absolute and relative measures, T test for independent samples for measurement comparisons and the Spearman correlation test. In the cognitive evaluation MMSE, those participants with AD present higher risk of cognitive decline (81.8%), greater risk of malnutrition according to MNA (45.5%) and altered levels of leptin (90.9%). Upon performing the comparison analysis between the group with AD and the control group, there existed noteworthy differences between the means for the variables MNA (4.40; BMI95% 2.75 – 6.06), MMSE (10.54; BMI95% 7.09 – 13.99) and doses of HDL (High Density Lipoproteins) (14.53; BMI95% 6.18 – 22.88). As well as differences in the p-value < 0.09 in the leptin doses (11.54; BMI95% (-24.98 – 1.89) and transferrin dose (-72.31; BMI95% -159.48 – 14.84). The Spearman correlation demonstrated that the cognitive decline in the group of senior citizens with AD was strongly associated with nutritional conditions MNA (R 0.484) and the leptin dose (R 0.590). Senior citizens with AD present worse nutritional conditions, cognitive decline and biochemical alterations when compared to senior citizens in the control group. As such, the study demonstrated the need for an integrated healthcare assistance concerning senior citizens with AD. 
publishDate 2020
dc.date.none.fl_str_mv 2020-12-16
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://seer.ufu.br/index.php/biosciencejournal/article/view/49979
10.14393/BJ-v36n6a2020-49979
url https://seer.ufu.br/index.php/biosciencejournal/article/view/49979
identifier_str_mv 10.14393/BJ-v36n6a2020-49979
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://seer.ufu.br/index.php/biosciencejournal/article/view/49979/30500
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.coverage.none.fl_str_mv Brazil; Contemporary
dc.publisher.none.fl_str_mv EDUFU
publisher.none.fl_str_mv EDUFU
dc.source.none.fl_str_mv Bioscience Journal ; Vol. 36 No. 6 (2020): Nov./Dec.; 2315-2329
Bioscience Journal ; v. 36 n. 6 (2020): Nov./Dec.; 2315-2329
1981-3163
reponame:Bioscience journal (Online)
instname:Universidade Federal de Uberlândia (UFU)
instacron:UFU
instname_str Universidade Federal de Uberlândia (UFU)
instacron_str UFU
institution UFU
reponame_str Bioscience journal (Online)
collection Bioscience journal (Online)
repository.name.fl_str_mv Bioscience journal (Online) - Universidade Federal de Uberlândia (UFU)
repository.mail.fl_str_mv biosciencej@ufu.br||
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