Evaluation of adipokine chemerin in hypertensive obese

Detalhes bibliográficos
Autor(a) principal: Ibrahim, Dalia Ramzy
Data de Publicação: 2019
Outros Autores: Taha, Mervat Elsayed, Kamal, Amaal Mohamed
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Bioscience journal (Online)
Texto Completo: https://seer.ufu.br/index.php/biosciencejournal/article/view/47937
Resumo: Chemerin is an adipokine secreted by adiopose tissue and has a role in obesity and hypertension. This study aims at assessing the level of the adipokine chemerin in obesity and/or hypertension and correlating its level with the inflammatory marker hs-CRP and predictors of atherosclerosis as lipid profile, insulin resistance, systolic (SBP) and diastolic blood pressure (DBP).Volunteers were divided into 4 equal groups according to body mass index (BMI) and blood pressure: normal weight group (BMI ≤ 24.9 kg/m2), overweight group (BMI = 25.0 – 29.9 kg/m2), normotensive obese group (BMI ≥ 30.0 kg/m2) and hypertensive obese group (BMI ≥ 30.0 kg/m2). Chemerin, high-sensitivity C-reactive protein (hs-CRP), lipid profile, fasting blood glucose (FBG) and fasting insulin (FI) were evaluated in the mentioned groups.The results showed that there were significant increases of chemerin, hs-CRP, low density lipoprotein (LDL), SBP and DBP in hypertensive obese group compared to normotensive obese , overweight and normal weight groups. Moreover the only significant positive correlation between chemerin and hs-CRP was observed in the obese hypertensive group. The normotensive obese group showed significant increases of hs-CRP, LDL, triglyceride (TG), FBG, FI and the homeostasis model assessment-insulin resistance index (HOMA-IR) compared to the overweight and normal weight groups. Regarding the overweight group, there were significant increases in chemerin, hs-CRP, cholesterol, LDL, TG compared to the normal weight group, while the HDL levels were significantly lower compared to the two obese groups. These results revealed that the pro-inflammatory adipokine chemerin increases in obesity associated with hypertension, leading to the suggestion that there is a definite dysregulation of the pro-inflammatory and anti-inflammatory parameters towards the pro-inflammatory when hypertension and obesity are associated.            
id UFU-14_662e1287698dd6700a4d7e7590f27688
oai_identifier_str oai:ojs.www.seer.ufu.br:article/47937
network_acronym_str UFU-14
network_name_str Bioscience journal (Online)
repository_id_str
spelling Evaluation of adipokine chemerin in hypertensive obeseAvaliação da adipocina chemerin em obesos hipertensosEssential hypertension.Cytokines.Pro-inflammation.Obesity.Health SciencesChemerin is an adipokine secreted by adiopose tissue and has a role in obesity and hypertension. This study aims at assessing the level of the adipokine chemerin in obesity and/or hypertension and correlating its level with the inflammatory marker hs-CRP and predictors of atherosclerosis as lipid profile, insulin resistance, systolic (SBP) and diastolic blood pressure (DBP).Volunteers were divided into 4 equal groups according to body mass index (BMI) and blood pressure: normal weight group (BMI ≤ 24.9 kg/m2), overweight group (BMI = 25.0 – 29.9 kg/m2), normotensive obese group (BMI ≥ 30.0 kg/m2) and hypertensive obese group (BMI ≥ 30.0 kg/m2). Chemerin, high-sensitivity C-reactive protein (hs-CRP), lipid profile, fasting blood glucose (FBG) and fasting insulin (FI) were evaluated in the mentioned groups.The results showed that there were significant increases of chemerin, hs-CRP, low density lipoprotein (LDL), SBP and DBP in hypertensive obese group compared to normotensive obese , overweight and normal weight groups. Moreover the only significant positive correlation between chemerin and hs-CRP was observed in the obese hypertensive group. The normotensive obese group showed significant increases of hs-CRP, LDL, triglyceride (TG), FBG, FI and the homeostasis model assessment-insulin resistance index (HOMA-IR) compared to the overweight and normal weight groups. Regarding the overweight group, there were significant increases in chemerin, hs-CRP, cholesterol, LDL, TG compared to the normal weight group, while the HDL levels were significantly lower compared to the two obese groups. These results revealed that the pro-inflammatory adipokine chemerin increases in obesity associated with hypertension, leading to the suggestion that there is a definite dysregulation of the pro-inflammatory and anti-inflammatory parameters towards the pro-inflammatory when hypertension and obesity are associated.            A chemerin é uma adipocina secretada pelo tecido adiposo e tem papel na obesidade e na hipertensão. Este estudo tem como objetivo avaliar o nível da adipocina chemerina na obesidade e / ou hipertensão e correlacionar seu nível com o marcador inflamatório hs-PCR e os preditores de aterosclerose como perfil lipídico, resistência à insulina, pressão arterial sistólica (PAS) e diastólica (PAD) Os voluntários foram divididos em 4 grupos iguais de acordo com o índice de massa corporal (IMC) e pressão arterial: grupo com peso normal (IMC ≤ 24,9 kg / m2), grupo com sobrepeso (IMC = 25,0 - 29,9 kg / m2), grupo obeso normotenso (IMC ≥ 30,0 kg / m2) e grupo obeso hipertenso (IMC ≥ 30,0 kg / m2). Chemerin, proteína C-reativa de alta sensibilidade (PCR-as), perfil lipídico, glicemia de jejum (FBG) e insulina de jejum (FI) foram avaliados nos grupos mencionados. Os resultados mostraram que houve aumentos significativos de chemerina, hs- CRP, lipoproteína de baixa densidade (LDL), PAS e PAD no grupo obeso hipertenso em comparação com obesos normotensos, com sobrepeso e com peso normal. Além disso, a única correlação positiva significativa entre chemerin e hs-CRP foi observada no grupo de hipertensos obesos. O grupo obeso normotenso apresentou aumentos significativos de PCR-as, LDL, triglicérides (TG), FBG, FI e o modelo de avaliação da homeostase - índice de resistência à insulina (HOMA-IR) comparado aos grupos com sobrepeso e peso normal. Em relação ao grupo com excesso de peso, houve aumento significativo de chemerina, PCR-as, colesterol, LDL, TG em relação ao grupo com peso normal, enquanto os níveis de HDL foram significativamente menores em comparação aos dois grupos obesos. Esses resultados revelaram que a pró-inflamatória adipocina chemerina aumenta na obesidade associada à hipertensão, levando à sugestão de que há uma desregulação definida dos parâmetros pró-inflamatórios e anti-inflamatórios em relação ao pró-inflamatório quando a hipertensão e a obesidade estão associadas.EDUFU2019-12-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://seer.ufu.br/index.php/biosciencejournal/article/view/4793710.14393/BJ-v35n6a2019-47937Bioscience Journal ; Vol. 35 No. 6 (2019): Nov./Dec.; 1958-1967Bioscience Journal ; v. 35 n. 6 (2019): Nov./Dec.; 1958-19671981-3163reponame:Bioscience journal (Online)instname:Universidade Federal de Uberlândia (UFU)instacron:UFUenghttps://seer.ufu.br/index.php/biosciencejournal/article/view/47937/27487Brazil; ContemporaryCopyright (c) 2019 Dalia Ramzy Ibrahim, Mervat Elsayed Taha, Amaal Mohamed Kamalhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessIbrahim, Dalia RamzyTaha, Mervat ElsayedKamal, Amaal Mohamed2022-01-25T22:49:24Zoai:ojs.www.seer.ufu.br:article/47937Revistahttps://seer.ufu.br/index.php/biosciencejournalPUBhttps://seer.ufu.br/index.php/biosciencejournal/oaibiosciencej@ufu.br||1981-31631516-3725opendoar:2022-01-25T22:49:24Bioscience journal (Online) - Universidade Federal de Uberlândia (UFU)false
dc.title.none.fl_str_mv Evaluation of adipokine chemerin in hypertensive obese
Avaliação da adipocina chemerin em obesos hipertensos
title Evaluation of adipokine chemerin in hypertensive obese
spellingShingle Evaluation of adipokine chemerin in hypertensive obese
Ibrahim, Dalia Ramzy
Essential hypertension.
Cytokines.
Pro-inflammation.
Obesity.
Health Sciences
title_short Evaluation of adipokine chemerin in hypertensive obese
title_full Evaluation of adipokine chemerin in hypertensive obese
title_fullStr Evaluation of adipokine chemerin in hypertensive obese
title_full_unstemmed Evaluation of adipokine chemerin in hypertensive obese
title_sort Evaluation of adipokine chemerin in hypertensive obese
author Ibrahim, Dalia Ramzy
author_facet Ibrahim, Dalia Ramzy
Taha, Mervat Elsayed
Kamal, Amaal Mohamed
author_role author
author2 Taha, Mervat Elsayed
Kamal, Amaal Mohamed
author2_role author
author
dc.contributor.author.fl_str_mv Ibrahim, Dalia Ramzy
Taha, Mervat Elsayed
Kamal, Amaal Mohamed
dc.subject.por.fl_str_mv Essential hypertension.
Cytokines.
Pro-inflammation.
Obesity.
Health Sciences
topic Essential hypertension.
Cytokines.
Pro-inflammation.
Obesity.
Health Sciences
description Chemerin is an adipokine secreted by adiopose tissue and has a role in obesity and hypertension. This study aims at assessing the level of the adipokine chemerin in obesity and/or hypertension and correlating its level with the inflammatory marker hs-CRP and predictors of atherosclerosis as lipid profile, insulin resistance, systolic (SBP) and diastolic blood pressure (DBP).Volunteers were divided into 4 equal groups according to body mass index (BMI) and blood pressure: normal weight group (BMI ≤ 24.9 kg/m2), overweight group (BMI = 25.0 – 29.9 kg/m2), normotensive obese group (BMI ≥ 30.0 kg/m2) and hypertensive obese group (BMI ≥ 30.0 kg/m2). Chemerin, high-sensitivity C-reactive protein (hs-CRP), lipid profile, fasting blood glucose (FBG) and fasting insulin (FI) were evaluated in the mentioned groups.The results showed that there were significant increases of chemerin, hs-CRP, low density lipoprotein (LDL), SBP and DBP in hypertensive obese group compared to normotensive obese , overweight and normal weight groups. Moreover the only significant positive correlation between chemerin and hs-CRP was observed in the obese hypertensive group. The normotensive obese group showed significant increases of hs-CRP, LDL, triglyceride (TG), FBG, FI and the homeostasis model assessment-insulin resistance index (HOMA-IR) compared to the overweight and normal weight groups. Regarding the overweight group, there were significant increases in chemerin, hs-CRP, cholesterol, LDL, TG compared to the normal weight group, while the HDL levels were significantly lower compared to the two obese groups. These results revealed that the pro-inflammatory adipokine chemerin increases in obesity associated with hypertension, leading to the suggestion that there is a definite dysregulation of the pro-inflammatory and anti-inflammatory parameters towards the pro-inflammatory when hypertension and obesity are associated.            
publishDate 2019
dc.date.none.fl_str_mv 2019-12-02
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://seer.ufu.br/index.php/biosciencejournal/article/view/47937
10.14393/BJ-v35n6a2019-47937
url https://seer.ufu.br/index.php/biosciencejournal/article/view/47937
identifier_str_mv 10.14393/BJ-v35n6a2019-47937
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://seer.ufu.br/index.php/biosciencejournal/article/view/47937/27487
dc.rights.driver.fl_str_mv Copyright (c) 2019 Dalia Ramzy Ibrahim, Mervat Elsayed Taha, Amaal Mohamed Kamal
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2019 Dalia Ramzy Ibrahim, Mervat Elsayed Taha, Amaal Mohamed Kamal
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.coverage.none.fl_str_mv Brazil; Contemporary
dc.publisher.none.fl_str_mv EDUFU
publisher.none.fl_str_mv EDUFU
dc.source.none.fl_str_mv Bioscience Journal ; Vol. 35 No. 6 (2019): Nov./Dec.; 1958-1967
Bioscience Journal ; v. 35 n. 6 (2019): Nov./Dec.; 1958-1967
1981-3163
reponame:Bioscience journal (Online)
instname:Universidade Federal de Uberlândia (UFU)
instacron:UFU
instname_str Universidade Federal de Uberlândia (UFU)
instacron_str UFU
institution UFU
reponame_str Bioscience journal (Online)
collection Bioscience journal (Online)
repository.name.fl_str_mv Bioscience journal (Online) - Universidade Federal de Uberlândia (UFU)
repository.mail.fl_str_mv biosciencej@ufu.br||
_version_ 1797069081676873728