IL-10 and IL-12 (P70) Levels Predict the Risk of Covid-19 Progression in Hypertensive Patients: Insights From the BRACE-CORONA Trial
| Autor(a) principal: | |
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| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/50537 |
Resumo: | Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil. |
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Moll-Bernardes, RenataSousa, Andrea Silvestre deMacedo, Ariane V. S.Lopes, Renato D.Vera, NarendraMaia, Luciana C. R.Feldman, AndréArruda, Guilherme D. A. S.Castro, Mauro J. C.Pimentel-Coelho, Pedro M.Albuquerque, Denílson C. dePaula, Thiago Ceccatto deFurquim, Thyago A. B.Loures, Vitor A.Giusti, Karla G. D.Oliveira, Nathália M. deDe Luca, Fábio A.Kotsugai, Marisol D. M.Domiciano, Rafael A. M.Santos, Mayara FragaSouza, Olga Ferreira deBozza, Fernando A.Luiz, Ronir RaggioMedei, Emiliano2021-12-28T13:42:35Z2021-12-28T13:42:35Z2021MOLL-BERNARDES, Renata et al. IL-10 and IL-12 (P70) Levels Predict the Risk of Covid-19 Progression in Hypertensive Patients: Insights From the BRACE-CORONA Trial. Frontiers in cardiovascular medicine, v. 8, p. 1-10, 20212297-055Xhttps://www.arca.fiocruz.br/handle/icict/5053710.3389/fcvm.2021.702507engFrontiers MediaIL-10 and IL-12 (P70) Levels Predict the Risk of Covid-19 Progression in Hypertensive Patients: Insights From the BRACE-CORONA Trialinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Hospital São Luiz Jabaquara. São Paulo, SP, Brasil / Santa Casa de São Paulo. São Paulo, SP, Brasil.Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Duke University Medical Center. Duke Clinical Research Institute. Durham, NC, United States / Instituto Brasileiro de Pesquisa Clínica. São Paulo, SP, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Hospital São Luiz Anália Franco. São Paulo, SP, Brasil.Hospital São Luiz São Caetano. São Caetano do Sul, SP, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Departamento de Cardiologia. Rio de Janeiro, RJ, Brasil.Hospital São Luiz Jabaquara. São Paulo, SP, Brasil.Hospital Sino Brasileiro. Osasco, SP, Brasil.Hospital São Luiz Anália Franco. São Paulo, SP, Brasil.Hospital Villa Lobos. São Paulo, SP, Brasil.Hospital Villa Lobos. São Paulo, SP, Brasil.Hospital São Luiz Morumbi. São Paulo, SP, Brasil.Hospital São Luiz Morumbi. São Paulo, SP, Brasil.Hospital São Luiz Anália Franco. São Paulo, SP, Brasil.Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Hospital Copa Star. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Estudos em Saúde Pública. Rio de Janeiro, RJ, Brasil.Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Centro Nacional de Biologia Estrutural e Bioimagem. Rio de Janeiro, RJ, Brasil.Background: Cardiovascular comorbidities such as hypertension and inflammatory response dysregulation are associated with worse COVID-19 prognoses. Different cytokines have been proposed to play vital pathophysiological roles in COVID-19 progression, but appropriate prognostic biomarkers remain lacking. We hypothesized that the combination of immunological and clinical variables at admission could predict the clinical progression of COVID-19 in hypertensive patients. Methods: The levels of biomarkers, including C-reactive protein, lymphocytes, monocytes, and a panel of 29 cytokines, were measured in blood samples from 167 hypertensive patients included in the BRACE-CORONA trial. The primary outcome was the highest score during hospitalization on the modified WHO Ordinal Scale for Clinical Improvement. The probability of progression to severe disease was estimated using a logistic regression model that included clinical variables and biomarkers associated significantly with the primary outcome. Results: During hospitalization, 13 (7.8%) patients showed progression to more severe forms of COVID-19, including three deaths. Obesity, diabetes, oxygen saturation, lung involvement on computed tomography examination, the C-reactive protein level, levels of 15 cytokines, and lymphopenia on admission were associated with progression to severe COVID-19. Elevated levels of interleukin-10 and interleukin-12 (p70) combined with two or three of the abovementioned clinical comorbidities were associated strongly with progression to severe COVID-19. The risk of progression to severe disease reached 97.5% in the presence of the five variables included in our model. Conclusions: This study demonstrated that interleukin-10 and interleukin-12 (p70) levels, in combination with clinical variables, at hospital admission are key biomarkers associated with an increased risk of disease progression in hypertensive patients with COVID-19.COVID-19BiomarkerCytokineHypertensionInflammationPrognosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/50537/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALIL-10_Fernando_Bozza_etal_INI_2021.pdfIL-10_Fernando_Bozza_etal_INI_2021.pdfapplication/pdf1134324https://www.arca.fiocruz.br/bitstream/icict/50537/2/IL-10_Fernando_Bozza_etal_INI_2021.pdff300e195790087cfc8353f17ae26fc64MD52icict/505372021-12-28 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| dc.title.pt_BR.fl_str_mv |
IL-10 and IL-12 (P70) Levels Predict the Risk of Covid-19 Progression in Hypertensive Patients: Insights From the BRACE-CORONA Trial |
| title |
IL-10 and IL-12 (P70) Levels Predict the Risk of Covid-19 Progression in Hypertensive Patients: Insights From the BRACE-CORONA Trial |
| spellingShingle |
IL-10 and IL-12 (P70) Levels Predict the Risk of Covid-19 Progression in Hypertensive Patients: Insights From the BRACE-CORONA Trial Moll-Bernardes, Renata COVID-19 Biomarker Cytokine Hypertension Inflammation Prognosis |
| title_short |
IL-10 and IL-12 (P70) Levels Predict the Risk of Covid-19 Progression in Hypertensive Patients: Insights From the BRACE-CORONA Trial |
| title_full |
IL-10 and IL-12 (P70) Levels Predict the Risk of Covid-19 Progression in Hypertensive Patients: Insights From the BRACE-CORONA Trial |
| title_fullStr |
IL-10 and IL-12 (P70) Levels Predict the Risk of Covid-19 Progression in Hypertensive Patients: Insights From the BRACE-CORONA Trial |
| title_full_unstemmed |
IL-10 and IL-12 (P70) Levels Predict the Risk of Covid-19 Progression in Hypertensive Patients: Insights From the BRACE-CORONA Trial |
| title_sort |
IL-10 and IL-12 (P70) Levels Predict the Risk of Covid-19 Progression in Hypertensive Patients: Insights From the BRACE-CORONA Trial |
| author |
Moll-Bernardes, Renata |
| author_facet |
Moll-Bernardes, Renata Sousa, Andrea Silvestre de Macedo, Ariane V. S. Lopes, Renato D. Vera, Narendra Maia, Luciana C. R. Feldman, André Arruda, Guilherme D. A. S. Castro, Mauro J. C. Pimentel-Coelho, Pedro M. Albuquerque, Denílson C. de Paula, Thiago Ceccatto de Furquim, Thyago A. B. Loures, Vitor A. Giusti, Karla G. D. Oliveira, Nathália M. de De Luca, Fábio A. Kotsugai, Marisol D. M. Domiciano, Rafael A. M. Santos, Mayara Fraga Souza, Olga Ferreira de Bozza, Fernando A. Luiz, Ronir Raggio Medei, Emiliano |
| author_role |
author |
| author2 |
Sousa, Andrea Silvestre de Macedo, Ariane V. S. Lopes, Renato D. Vera, Narendra Maia, Luciana C. R. Feldman, André Arruda, Guilherme D. A. S. Castro, Mauro J. C. Pimentel-Coelho, Pedro M. Albuquerque, Denílson C. de Paula, Thiago Ceccatto de Furquim, Thyago A. B. Loures, Vitor A. Giusti, Karla G. D. Oliveira, Nathália M. de De Luca, Fábio A. Kotsugai, Marisol D. M. Domiciano, Rafael A. M. Santos, Mayara Fraga Souza, Olga Ferreira de Bozza, Fernando A. Luiz, Ronir Raggio Medei, Emiliano |
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author author author author author author author author author author author author author author author author author author author author author author author |
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Moll-Bernardes, Renata Sousa, Andrea Silvestre de Macedo, Ariane V. S. Lopes, Renato D. Vera, Narendra Maia, Luciana C. R. Feldman, André Arruda, Guilherme D. A. S. Castro, Mauro J. C. Pimentel-Coelho, Pedro M. Albuquerque, Denílson C. de Paula, Thiago Ceccatto de Furquim, Thyago A. B. Loures, Vitor A. Giusti, Karla G. D. Oliveira, Nathália M. de De Luca, Fábio A. Kotsugai, Marisol D. M. Domiciano, Rafael A. M. Santos, Mayara Fraga Souza, Olga Ferreira de Bozza, Fernando A. Luiz, Ronir Raggio Medei, Emiliano |
| dc.subject.en.pt_BR.fl_str_mv |
COVID-19 Biomarker Cytokine Hypertension Inflammation Prognosis |
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COVID-19 Biomarker Cytokine Hypertension Inflammation Prognosis |
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Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil. |
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2021 |
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2021-12-28T13:42:35Z |
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2021-12-28T13:42:35Z |
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2021 |
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MOLL-BERNARDES, Renata et al. IL-10 and IL-12 (P70) Levels Predict the Risk of Covid-19 Progression in Hypertensive Patients: Insights From the BRACE-CORONA Trial. Frontiers in cardiovascular medicine, v. 8, p. 1-10, 2021 |
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https://www.arca.fiocruz.br/handle/icict/50537 |
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2297-055X |
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10.3389/fcvm.2021.702507 |
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MOLL-BERNARDES, Renata et al. IL-10 and IL-12 (P70) Levels Predict the Risk of Covid-19 Progression in Hypertensive Patients: Insights From the BRACE-CORONA Trial. Frontiers in cardiovascular medicine, v. 8, p. 1-10, 2021 2297-055X 10.3389/fcvm.2021.702507 |
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