Free activity in the cage associated with body weight gain restores bone structural and mechanical properties in growing rats after hindlimb unloading

Detalhes bibliográficos
Autor(a) principal: Barbosa, Adelton Andrade
Data de Publicação: 2012
Outros Autores: Del Carlo, Ricardo Junqueira, Galvão, Simone Rezende, Louzada, Mário Jefferson Quirino, Franco, Frederico Souzalima Caldoncelli, Fernandes, Bárbara Braga, Carneiro-Junior, Miguel Araújo, Ramos, Regiane Maria Soares, Drummond, Lucas Rios, Natali, Antonio Jose
Tipo de documento: Artigo
Idioma: por
Título da fonte: Bioscience journal (Online)
Texto Completo: https://seer.ufu.br/index.php/biosciencejournal/article/view/9159
Resumo: We investigated the importance of daily free activity in the cage and body weight gain during the recovering of bone structural and mechanical properties in growing rats after hindlimb unloading. Eight-week-old male Wistar rats were randomly divided into control (CG, n=24) and suspended (SG, n=24) groups. Animals from SG underwent a four-week hindlimb unloading period by tail-suspension. Animals from CG and those from SG after release were kept in collective cages and sacrificed at the age of 12, 16 and 20 weeks. Both femurs were removed and its area, bone mineral density (BMD), resistance to failure and stiffness were determined. Four-week hindlimb unloading decreased (p0.05) the body weight (CG, 472.75 ± 14.11 vs. SG, 444.75 ± 18.91 g), BMD (CG, 0.24 ± 0.01 vs. SG, 0.22 ± 0.01 g/cm2), bone resistance to failure (CG, 195.73 ± 10.06 vs. SG, 178.45 ± 8.48 N) and stiffness (CG, 0.56 ± 0.02 vs. SG, 0.47± 0.03 N/m) of SG animals. Body weight correlated strongly with bone structural and mechanical properties (p
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spelling Free activity in the cage associated with body weight gain restores bone structural and mechanical properties in growing rats after hindlimb unloading Health SciencesWe investigated the importance of daily free activity in the cage and body weight gain during the recovering of bone structural and mechanical properties in growing rats after hindlimb unloading. Eight-week-old male Wistar rats were randomly divided into control (CG, n=24) and suspended (SG, n=24) groups. Animals from SG underwent a four-week hindlimb unloading period by tail-suspension. Animals from CG and those from SG after release were kept in collective cages and sacrificed at the age of 12, 16 and 20 weeks. Both femurs were removed and its area, bone mineral density (BMD), resistance to failure and stiffness were determined. Four-week hindlimb unloading decreased (p0.05) the body weight (CG, 472.75 ± 14.11 vs. SG, 444.75 ± 18.91 g), BMD (CG, 0.24 ± 0.01 vs. SG, 0.22 ± 0.01 g/cm2), bone resistance to failure (CG, 195.73 ± 10.06 vs. SG, 178.45 ± 8.48 N) and stiffness (CG, 0.56 ± 0.02 vs. SG, 0.47± 0.03 N/m) of SG animals. Body weight correlated strongly with bone structural and mechanical properties (pEDUFU2012-09-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://seer.ufu.br/index.php/biosciencejournal/article/view/9159Bioscience Journal ; Vol. 28 No. 4 (2012): July/Aug.; 660-666Bioscience Journal ; v. 28 n. 4 (2012): July/Aug.; 660-6661981-3163reponame:Bioscience journal (Online)instname:Universidade Federal de Uberlândia (UFU)instacron:UFUporhttps://seer.ufu.br/index.php/biosciencejournal/article/view/9159/9758Brazil; ContemporanyCopyright (c) 2012 Adelton Andrade Barbosa, Ricardo Junqueira Del Carlo, Simone Rezende Galvão, Mário Jefferson Quirino Louzada, Frederico Souzalima Caldoncelli Franco, Bárbara Braga Fernandes, Miguel Araújo Carneiro-Junior, Regiane Maria Soares Ramos, Lucas Rios Drummond, Antonio Jose Natalihttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBarbosa, Adelton AndradeDel Carlo, Ricardo JunqueiraGalvão, Simone RezendeLouzada, Mário Jefferson QuirinoFranco, Frederico Souzalima CaldoncelliFernandes, Bárbara BragaCarneiro-Junior, Miguel AraújoRamos, Regiane Maria SoaresDrummond, Lucas RiosNatali, Antonio Jose2022-06-02T14:05:50Zoai:ojs.www.seer.ufu.br:article/9159Revistahttps://seer.ufu.br/index.php/biosciencejournalPUBhttps://seer.ufu.br/index.php/biosciencejournal/oaibiosciencej@ufu.br||1981-31631516-3725opendoar:2022-06-02T14:05:50Bioscience journal (Online) - Universidade Federal de Uberlândia (UFU)false
dc.title.none.fl_str_mv Free activity in the cage associated with body weight gain restores bone structural and mechanical properties in growing rats after hindlimb unloading
title Free activity in the cage associated with body weight gain restores bone structural and mechanical properties in growing rats after hindlimb unloading
spellingShingle Free activity in the cage associated with body weight gain restores bone structural and mechanical properties in growing rats after hindlimb unloading
Barbosa, Adelton Andrade
Health Sciences
title_short Free activity in the cage associated with body weight gain restores bone structural and mechanical properties in growing rats after hindlimb unloading
title_full Free activity in the cage associated with body weight gain restores bone structural and mechanical properties in growing rats after hindlimb unloading
title_fullStr Free activity in the cage associated with body weight gain restores bone structural and mechanical properties in growing rats after hindlimb unloading
title_full_unstemmed Free activity in the cage associated with body weight gain restores bone structural and mechanical properties in growing rats after hindlimb unloading
title_sort Free activity in the cage associated with body weight gain restores bone structural and mechanical properties in growing rats after hindlimb unloading
author Barbosa, Adelton Andrade
author_facet Barbosa, Adelton Andrade
Del Carlo, Ricardo Junqueira
Galvão, Simone Rezende
Louzada, Mário Jefferson Quirino
Franco, Frederico Souzalima Caldoncelli
Fernandes, Bárbara Braga
Carneiro-Junior, Miguel Araújo
Ramos, Regiane Maria Soares
Drummond, Lucas Rios
Natali, Antonio Jose
author_role author
author2 Del Carlo, Ricardo Junqueira
Galvão, Simone Rezende
Louzada, Mário Jefferson Quirino
Franco, Frederico Souzalima Caldoncelli
Fernandes, Bárbara Braga
Carneiro-Junior, Miguel Araújo
Ramos, Regiane Maria Soares
Drummond, Lucas Rios
Natali, Antonio Jose
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Barbosa, Adelton Andrade
Del Carlo, Ricardo Junqueira
Galvão, Simone Rezende
Louzada, Mário Jefferson Quirino
Franco, Frederico Souzalima Caldoncelli
Fernandes, Bárbara Braga
Carneiro-Junior, Miguel Araújo
Ramos, Regiane Maria Soares
Drummond, Lucas Rios
Natali, Antonio Jose
dc.subject.por.fl_str_mv Health Sciences
topic Health Sciences
description We investigated the importance of daily free activity in the cage and body weight gain during the recovering of bone structural and mechanical properties in growing rats after hindlimb unloading. Eight-week-old male Wistar rats were randomly divided into control (CG, n=24) and suspended (SG, n=24) groups. Animals from SG underwent a four-week hindlimb unloading period by tail-suspension. Animals from CG and those from SG after release were kept in collective cages and sacrificed at the age of 12, 16 and 20 weeks. Both femurs were removed and its area, bone mineral density (BMD), resistance to failure and stiffness were determined. Four-week hindlimb unloading decreased (p0.05) the body weight (CG, 472.75 ± 14.11 vs. SG, 444.75 ± 18.91 g), BMD (CG, 0.24 ± 0.01 vs. SG, 0.22 ± 0.01 g/cm2), bone resistance to failure (CG, 195.73 ± 10.06 vs. SG, 178.45 ± 8.48 N) and stiffness (CG, 0.56 ± 0.02 vs. SG, 0.47± 0.03 N/m) of SG animals. Body weight correlated strongly with bone structural and mechanical properties (p
publishDate 2012
dc.date.none.fl_str_mv 2012-09-03
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://seer.ufu.br/index.php/biosciencejournal/article/view/9159
url https://seer.ufu.br/index.php/biosciencejournal/article/view/9159
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://seer.ufu.br/index.php/biosciencejournal/article/view/9159/9758
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.coverage.none.fl_str_mv Brazil; Contemporany
dc.publisher.none.fl_str_mv EDUFU
publisher.none.fl_str_mv EDUFU
dc.source.none.fl_str_mv Bioscience Journal ; Vol. 28 No. 4 (2012): July/Aug.; 660-666
Bioscience Journal ; v. 28 n. 4 (2012): July/Aug.; 660-666
1981-3163
reponame:Bioscience journal (Online)
instname:Universidade Federal de Uberlândia (UFU)
instacron:UFU
instname_str Universidade Federal de Uberlândia (UFU)
instacron_str UFU
institution UFU
reponame_str Bioscience journal (Online)
collection Bioscience journal (Online)
repository.name.fl_str_mv Bioscience journal (Online) - Universidade Federal de Uberlândia (UFU)
repository.mail.fl_str_mv biosciencej@ufu.br||
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