Serotonina N-Acetiltransferase: Um estudo bioinformático

• Autor(a) principal: Veloso, Leticia Oliveira
• Data de Publicação: 2018
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UFU
• Texto Completo: https://repositorio.ufu.br/handle/123456789/23394
• topic: 5-Hidroxitriptamina; 5-Hydroxytryptamine; Proteína 14-3-3 Zeta; 14-3-3 Zeta Protein; Bioinformática; Bioinformatic; CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA; CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA

Serotonin also known as 5-hydroxytryptamine is found in the nervous system, gastrointestinal tract and platelets, and can act as a neurotransmitter and hormone, influencing different physiological processes. It is also classified as an enzyme belonging to the class of transferases and subclass of acyltransferases. Due to its classification, it may have different names, including serotonin N-acetyltransferase. In its synthesis, serotonin has as precursor tryptophan, an aromatic amino acid, which can only be obtained by diet. Through bioinformatics tools, available in open access databases, biochemical pathways and the physiological effects of serotonin in the body have been revealed. Thus, it was observed that serotonin is present in several tissues and cell types, and is localized mainly in the endoplasmic reticulum, being linked to some processes, such as mood modulation, sleep-wake cycle, motivation, pain perception, hallucinations, and stereotyped behavior, among others. In addition, it has been found that there are about 11 different types of serotonergic receptors, as well as some drugs that may be linked to them (sumatriptan, buspirone, ondansetron, tropizetrona and granisetrona). The metabolic pathways analysis in which serotonin is involved, has described its precursors (tryptophan and 5-hydroxytryptophan), involved enzymes (tryptophan hydroxylase, dopamine decarboxylase and serotonin N-acetyltransferase) and products (serotonin and N-acetyl-serotonin). Moreover, its biochemical structural characterization through its primary sequence, which allowed homology analysis of Homo sapiens sequence with other species, showing similarity rates ranging from 98 to 77% for mammals and 69% for birds (Gallus gallus). In conclusion, data on serotonin N-acetyltransferase, its biochemical routes, molecular structure, ligands, cell localization and homology analysis those were information fragmented and isolated in several databases, are now consolidated as an in-depth research on the subject, and can be used as a reference for other studies in macromolecule chemistry.