Epidemiological distribution and evolutionary profile of mayaro virus in the americas: an update into genome variability

Detalhes bibliográficos
Autor(a) principal: Marinho, Mikaela dos Santos
Data de Publicação: 2022
Outros Autores: Ferreira, Giulia Magalhães, Santos, Igor Andrade, Grosche, Victoria Riquena, Jardim, Ana Carolina Gomes
Tipo de documento: Trabalho de conclusão de curso
Idioma: eng
Título da fonte: Repositório Institucional da UFU
Texto Completo: https://repositorio.ufu.br/handle/123456789/35324
Resumo: Trabalho de Conclusão de Curso (Graduação)
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spelling Epidemiological distribution and evolutionary profile of mayaro virus in the americas: an update into genome variabilityDISTRIBUIÇÃO EPIDEMIOLÓGICA E PERFIL EVOLUTIVO DO VÍRUS MAYARO NAS AMÉRICAS: UMA ATUALIZAÇÃO SOBRE A VARIABILIDADE DO GENOMAArbovirusesArbovírusBioinformaticsBioinformáticaGenomic variabilityVariabilidade genômicaMayaro virusVírus mayaroMayaro feverFebre do mayaroCNPQ::CIENCIAS BIOLOGICASCNPQ::CIENCIAS BIOLOGICAS::MICROBIOLOGIACNPQ::CIENCIAS BIOLOGICAS::GENETICA::GENETICA MOLECULAR E DE MICROORGANISMOSTrabalho de Conclusão de Curso (Graduação)Mayaro virus (MAYV) is the etiologic agent of Mayaro Fever, a disease characterized by dengue-like symptoms and arthralgias that can progress to a chronic condition. MAYV is phylogenetically classified into the genotypes D (widely dispersed), L (limited), and N (new), being the D the most common. Additionally, a new genotype was generated by a recombination event between L and D, resulting in the genotype L/D. There are limited epidemiological and evolutionary studies on MAYV, resulting in the difficulty in tracking the emerging potential of this virus. In this context, here we investigated the MAYV genomic variations in sequences from different regions of America, and characterized the phylogenetic relationship among virus strains. Through the analysis of 40 complete genome sequences of MAYV from the GenBank database, uploaded in South, Central, and North American Countries, the phylogenetic tree was reconstructed, showing that sequences grouped according to the genotypes L, D, and L/D. Sequences characterized as genotype D were closely related to sequences from their respective countries, suggesting that isolates may had originated from circulating lineages in the respective countries. In addition, an unidentified sequence from the United States of America grouped with the genotype D, suggesting the insertion of this genotype in the country. Furthermore, our data demonstrated that a sequence previously characterized as genotype L grouped with isolates of genotype L/D, and presented an insertion of nucleotides into the nsP3, positioned identically to the genotype L/D. These results were also corroborated by our recombination analysis, which also identified this isolate as L/D hybrid. The analysis of amino acid mutations among sequences indicated positive and negative selective pressure sites, suggesting adaptability of viral fitness. These results provide information on the epidemiological distribution and evolutionary profile of MAYV, contributing to a better understanding of genotypes circulating in the Americas, as well as the potential viral changes that may contribute to the emergence of mutation of interest or new viral genotypes.2023-06-10Universidade Federal de UberlândiaBrasilBiomedicinaFerreira, Giulia Magalhãeshttp://lattes.cnpq.br/6522135001572733Jardim, Ana Carolina Gomeshttp://lattes.cnpq.br/7960921685798643Jardim, Ana Carolina Gomeshttp://lattes.cnpq.br/7960921685798643Costa, Larissa Catharinahttp://lattes.cnpq.br/2127725221876097Souza, William Marciel dehttp://lattes.cnpq.br/7191168464519008Marinho, Mikaela dos SantosFerreira, Giulia MagalhãesSantos, Igor AndradeGrosche, Victoria RiquenaJardim, Ana Carolina Gomes2022-07-28T17:47:04Z2022-07-28T17:47:04Z2022-06-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisapplication/pdfMARINHO, Mikaela dos Santos. Epidemiological distribution and evolutionary profile of Mayaro virus in the Americas: an update into genome variability, 2022. 32 f. Trabalho de Conclusão de Curso (Graduação em Biomedicina) – Universidade Federal de Uberlândia, Uberlândia, 2022.https://repositorio.ufu.br/handle/123456789/35324enghttp://creativecommons.org/licenses/by-nc-nd/3.0/us/info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFUinstname:Universidade Federal de Uberlândia (UFU)instacron:UFU2024-08-05T14:31:36Zoai:repositorio.ufu.br:123456789/35324Repositório InstitucionalONGhttp://repositorio.ufu.br/oai/requestdiinf@dirbi.ufu.bropendoar:2024-08-05T14:31:36Repositório Institucional da UFU - Universidade Federal de Uberlândia (UFU)false
dc.title.none.fl_str_mv Epidemiological distribution and evolutionary profile of mayaro virus in the americas: an update into genome variability
DISTRIBUIÇÃO EPIDEMIOLÓGICA E PERFIL EVOLUTIVO DO VÍRUS MAYARO NAS AMÉRICAS: UMA ATUALIZAÇÃO SOBRE A VARIABILIDADE DO GENOMA
title Epidemiological distribution and evolutionary profile of mayaro virus in the americas: an update into genome variability
spellingShingle Epidemiological distribution and evolutionary profile of mayaro virus in the americas: an update into genome variability
Marinho, Mikaela dos Santos
Arboviruses
Arbovírus
Bioinformatics
Bioinformática
Genomic variability
Variabilidade genômica
Mayaro virus
Vírus mayaro
Mayaro fever
Febre do mayaro
CNPQ::CIENCIAS BIOLOGICAS
CNPQ::CIENCIAS BIOLOGICAS::MICROBIOLOGIA
CNPQ::CIENCIAS BIOLOGICAS::GENETICA::GENETICA MOLECULAR E DE MICROORGANISMOS
title_short Epidemiological distribution and evolutionary profile of mayaro virus in the americas: an update into genome variability
title_full Epidemiological distribution and evolutionary profile of mayaro virus in the americas: an update into genome variability
title_fullStr Epidemiological distribution and evolutionary profile of mayaro virus in the americas: an update into genome variability
title_full_unstemmed Epidemiological distribution and evolutionary profile of mayaro virus in the americas: an update into genome variability
title_sort Epidemiological distribution and evolutionary profile of mayaro virus in the americas: an update into genome variability
author Marinho, Mikaela dos Santos
author_facet Marinho, Mikaela dos Santos
Ferreira, Giulia Magalhães
Santos, Igor Andrade
Grosche, Victoria Riquena
Jardim, Ana Carolina Gomes
author_role author
author2 Ferreira, Giulia Magalhães
Santos, Igor Andrade
Grosche, Victoria Riquena
Jardim, Ana Carolina Gomes
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ferreira, Giulia Magalhães
http://lattes.cnpq.br/6522135001572733
Jardim, Ana Carolina Gomes
http://lattes.cnpq.br/7960921685798643
Jardim, Ana Carolina Gomes
http://lattes.cnpq.br/7960921685798643
Costa, Larissa Catharina
http://lattes.cnpq.br/2127725221876097
Souza, William Marciel de
http://lattes.cnpq.br/7191168464519008
dc.contributor.author.fl_str_mv Marinho, Mikaela dos Santos
Ferreira, Giulia Magalhães
Santos, Igor Andrade
Grosche, Victoria Riquena
Jardim, Ana Carolina Gomes
dc.subject.por.fl_str_mv Arboviruses
Arbovírus
Bioinformatics
Bioinformática
Genomic variability
Variabilidade genômica
Mayaro virus
Vírus mayaro
Mayaro fever
Febre do mayaro
CNPQ::CIENCIAS BIOLOGICAS
CNPQ::CIENCIAS BIOLOGICAS::MICROBIOLOGIA
CNPQ::CIENCIAS BIOLOGICAS::GENETICA::GENETICA MOLECULAR E DE MICROORGANISMOS
topic Arboviruses
Arbovírus
Bioinformatics
Bioinformática
Genomic variability
Variabilidade genômica
Mayaro virus
Vírus mayaro
Mayaro fever
Febre do mayaro
CNPQ::CIENCIAS BIOLOGICAS
CNPQ::CIENCIAS BIOLOGICAS::MICROBIOLOGIA
CNPQ::CIENCIAS BIOLOGICAS::GENETICA::GENETICA MOLECULAR E DE MICROORGANISMOS
description Trabalho de Conclusão de Curso (Graduação)
publishDate 2022
dc.date.none.fl_str_mv 2022-07-28T17:47:04Z
2022-07-28T17:47:04Z
2022-06-10
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/bachelorThesis
format bachelorThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv MARINHO, Mikaela dos Santos. Epidemiological distribution and evolutionary profile of Mayaro virus in the Americas: an update into genome variability, 2022. 32 f. Trabalho de Conclusão de Curso (Graduação em Biomedicina) – Universidade Federal de Uberlândia, Uberlândia, 2022.
https://repositorio.ufu.br/handle/123456789/35324
identifier_str_mv MARINHO, Mikaela dos Santos. Epidemiological distribution and evolutionary profile of Mayaro virus in the Americas: an update into genome variability, 2022. 32 f. Trabalho de Conclusão de Curso (Graduação em Biomedicina) – Universidade Federal de Uberlândia, Uberlândia, 2022.
url https://repositorio.ufu.br/handle/123456789/35324
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/3.0/us/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/3.0/us/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Uberlândia
Brasil
Biomedicina
publisher.none.fl_str_mv Universidade Federal de Uberlândia
Brasil
Biomedicina
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFU
instname:Universidade Federal de Uberlândia (UFU)
instacron:UFU
instname_str Universidade Federal de Uberlândia (UFU)
instacron_str UFU
institution UFU
reponame_str Repositório Institucional da UFU
collection Repositório Institucional da UFU
repository.name.fl_str_mv Repositório Institucional da UFU - Universidade Federal de Uberlândia (UFU)
repository.mail.fl_str_mv diinf@dirbi.ufu.br
_version_ 1813711282693472256

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