Enxerto osteocondral alógeno, associado à inoculação de células mononucleares da medula óssea e Dexametasona no reparo da tróclea de coelhos

• Autor(a) principal: Alves, Lorena Borges
• Data de Publicação: 2011
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da UFU
• Texto Completo: https://repositorio.ufu.br/handle/123456789/12991
• topic: Medula óssea; Osso; Ossos - Enxerto; Células-tronco; Joelho; Genus; Bone; Bone marrow; CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA

Trauma, congenital deformities, tumors and infections often affected the articulation genus, with poor prognosis due to its limited regeneration capacity. This study evaluated the effectiveness of osteochondral graft preserved in glycerin 98% associated with mononuclear cells cells and dexamethasone in bone repair and cartilage of the trochlear groove. We used 24 New Zealand rabbits were randomly separated into two groups, each with twelve animals. All animals were subjected to graft osteochondral allograft of the trochlear groove, preserved in 98% glycerin and evaluated with 45 and 90 days postoperatively. The treated group also received intra-articular injection containing 2.0 x 106 mononuclear cells and intramuscular dexamethasone. The implantation of allogenic osteochondral graft preserved in glycerin 98% associated with injection of mononuclear cells and dexamethasone promotes endochondral ossification and reduces inflammation in rabbits.