Identification of mutations potentially associated with Chemoradiotherapy Treatment response in cervical cancer

Detalhes bibliográficos
Autor(a) principal: Facciolo Filho, Antonio Carlos
Data de Publicação: 2023
Tipo de documento: Trabalho de conclusão de curso
Idioma: eng
Título da fonte: Repositório Institucional da UFU
Texto Completo: https://repositorio.ufu.br/handle/123456789/38461
Resumo: Pesquisa sem auxílio de agências de fomento
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spelling Identification of mutations potentially associated with Chemoradiotherapy Treatment response in cervical cancerCervical cancerRNA-seqChemoradiotherapySomatic mutationsMUC6NAP1L1PABPC1NLRP4CNPQ::CIENCIAS BIOLOGICAS::GENETICA::GENETICA HUMANA E MEDICAPesquisa sem auxílio de agências de fomentoTrabalho de Conclusão de Curso (Graduação)Chemoradiotherapy resistance can significantly influence treatment outcomes in cervical cancer patients. Somatic variants play a crucial role in tumor development and treatment response. This study aimed to identify potentially clinically significant variants associated with chemoradiotherapy response using RNA-seq data analysis. RNA-seq data from 31 cervical cancer patients were subjected to variant calling and subsequent analysis using a machine learning decision tree algorithm. Variants within coding genes were selected based on their potential to segregate non-responder and responder patients. The selected variants were further assessed using variant impact prediction tools. We identified and investigated variants that exhibited potential to act as biomarkers for poor chemoradiotherapy response. Comprehensive analysis using variant impact prediction tools indicated that these variants may have deleterious effects on gene function. The genes harboring these variants were found to be involved in crucial cellular processes associated with cancer progression, including cell cycle regulation, proliferation, and notably, drug resistance. Our findings suggest that specific variants, namely MUC6(NM_005961.3):c.5992C>A, PABPC1(NM_002568.4):c.1255C>T, NAP1L1(NM_004537.7):c.1064_1065delinsGG, and NLRP4(NM_134444.5):c.1488_1489insT, have the potential to serve as indicators of poor chemoradiotherapy response in cervical cancer patients.Universidade Federal de UberlândiaBrasilBiotecnologiaAlves, Tamires Caixetahttp://lattes.cnpq.br/8597119747634649Gomes, Matheus de Souzahttp://lattes.cnpq.br/8674610062329213Melo, Carolina Pereira de Souzahttp://lattes.cnpq.br/4478543227984173Araújo, Carlos Brunohttp://lattes.cnpq.br/7810817113256976Facciolo Filho, Antonio Carlos2023-07-07T12:35:50Z2023-07-07T12:35:50Z2023-06-23info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisapplication/pdfFACCIOLO FILHO, Antonio Carlos. Identification of mutations potentially associated with Chemoradiotherapy Treatment response in cervical cancer. 2023. 42 f. Trabalho de Conclusão de Curso (Graduação em Biotecnologia) – Universidade Federal de Uberlândia, Uberlândia, 2023.https://repositorio.ufu.br/handle/123456789/38461enghttp://creativecommons.org/licenses/by-nc-nd/3.0/us/info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFUinstname:Universidade Federal de Uberlândia (UFU)instacron:UFU2023-07-08T06:20:54Zoai:repositorio.ufu.br:123456789/38461Repositório InstitucionalONGhttp://repositorio.ufu.br/oai/requestdiinf@dirbi.ufu.bropendoar:2023-07-08T06:20:54Repositório Institucional da UFU - Universidade Federal de Uberlândia (UFU)false
dc.title.none.fl_str_mv Identification of mutations potentially associated with Chemoradiotherapy Treatment response in cervical cancer
title Identification of mutations potentially associated with Chemoradiotherapy Treatment response in cervical cancer
spellingShingle Identification of mutations potentially associated with Chemoradiotherapy Treatment response in cervical cancer
Facciolo Filho, Antonio Carlos
Cervical cancer
RNA-seq
Chemoradiotherapy
Somatic mutations
MUC6
NAP1L1
PABPC1
NLRP4
CNPQ::CIENCIAS BIOLOGICAS::GENETICA::GENETICA HUMANA E MEDICA
title_short Identification of mutations potentially associated with Chemoradiotherapy Treatment response in cervical cancer
title_full Identification of mutations potentially associated with Chemoradiotherapy Treatment response in cervical cancer
title_fullStr Identification of mutations potentially associated with Chemoradiotherapy Treatment response in cervical cancer
title_full_unstemmed Identification of mutations potentially associated with Chemoradiotherapy Treatment response in cervical cancer
title_sort Identification of mutations potentially associated with Chemoradiotherapy Treatment response in cervical cancer
author Facciolo Filho, Antonio Carlos
author_facet Facciolo Filho, Antonio Carlos
author_role author
dc.contributor.none.fl_str_mv Alves, Tamires Caixeta
http://lattes.cnpq.br/8597119747634649
Gomes, Matheus de Souza
http://lattes.cnpq.br/8674610062329213
Melo, Carolina Pereira de Souza
http://lattes.cnpq.br/4478543227984173
Araújo, Carlos Bruno
http://lattes.cnpq.br/7810817113256976
dc.contributor.author.fl_str_mv Facciolo Filho, Antonio Carlos
dc.subject.por.fl_str_mv Cervical cancer
RNA-seq
Chemoradiotherapy
Somatic mutations
MUC6
NAP1L1
PABPC1
NLRP4
CNPQ::CIENCIAS BIOLOGICAS::GENETICA::GENETICA HUMANA E MEDICA
topic Cervical cancer
RNA-seq
Chemoradiotherapy
Somatic mutations
MUC6
NAP1L1
PABPC1
NLRP4
CNPQ::CIENCIAS BIOLOGICAS::GENETICA::GENETICA HUMANA E MEDICA
description Pesquisa sem auxílio de agências de fomento
publishDate 2023
dc.date.none.fl_str_mv 2023-07-07T12:35:50Z
2023-07-07T12:35:50Z
2023-06-23
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/bachelorThesis
format bachelorThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv FACCIOLO FILHO, Antonio Carlos. Identification of mutations potentially associated with Chemoradiotherapy Treatment response in cervical cancer. 2023. 42 f. Trabalho de Conclusão de Curso (Graduação em Biotecnologia) – Universidade Federal de Uberlândia, Uberlândia, 2023.
https://repositorio.ufu.br/handle/123456789/38461
identifier_str_mv FACCIOLO FILHO, Antonio Carlos. Identification of mutations potentially associated with Chemoradiotherapy Treatment response in cervical cancer. 2023. 42 f. Trabalho de Conclusão de Curso (Graduação em Biotecnologia) – Universidade Federal de Uberlândia, Uberlândia, 2023.
url https://repositorio.ufu.br/handle/123456789/38461
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/3.0/us/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/3.0/us/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Uberlândia
Brasil
Biotecnologia
publisher.none.fl_str_mv Universidade Federal de Uberlândia
Brasil
Biotecnologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFU
instname:Universidade Federal de Uberlândia (UFU)
instacron:UFU
instname_str Universidade Federal de Uberlândia (UFU)
instacron_str UFU
institution UFU
reponame_str Repositório Institucional da UFU
collection Repositório Institucional da UFU
repository.name.fl_str_mv Repositório Institucional da UFU - Universidade Federal de Uberlândia (UFU)
repository.mail.fl_str_mv diinf@dirbi.ufu.br
_version_ 1813711398801244160

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