Evaluation of solid-liquid extraction of levodopa from mucuna seeds using different solvents

Detalhes bibliográficos
Autor(a) principal: Sousa, Rita de Cássia Superbi de
Data de Publicação: 2024
Outros Autores: Quieli, Giovani da Silva, Monteiro , Thais Pinto Coelho, Costa , Angélica Ribeiro da, Benfica, Jordana
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista de Engenharia Química e Química
Texto Completo: https://periodicos.ufv.br/jcec/article/view/18218
Resumo: Levodopa is the main drug currently used to treat Parkinson's disease. This amino acid, found in the mucuna seed, is a direct precursor to dopamine, which acts to reduce and control of disease’s symptoms. The commercially available levodopa is produced synthetically, however, due to the relevance of the topic, studies have been carried out to find alternatives for extracting this compound from natural sources, making the process more economical and sustainable with the use of alternative solvents. In this study, the objective was to characterize the seeds of gray mucuna (Mucuna cinerea) and evaluate the solid-liquid extraction yield of levodopa, using different solvents (benzoic acid, succinic acid, choline chloride, ethanol, PEG 4000 and water). To evaluate which solvents and factors most influenced the extraction yield, a factorial design (23) was carried out. The factors were temperature, extraction time and the ratio between solid and solvent. Composition analysis showed that mucuna is rich in proteins with 26.49% and carbohydrates with 50.63%, has 10.16% minerals, 4.08% lipids and 8.64% moisture. Levodopa was quantified using high-performance liquid chromatography, with an aqueous mixture of water and ethanol 50% m/m being the most suitable solvent for extraction, achieving a yield of 14.14%.
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spelling Evaluation of solid-liquid extraction of levodopa from mucuna seeds using different solventsEvaluación de la extracción sólido-líquido de levodopa a partir de semillas de mucuna utilizando diferentes solventesÉvaluation de l'extraction solide-liquide de la lévodopa à partir de graines de mucuna à l'aide de différents solvantsAvaliação da extração sólido-líquido de levodopa a partir de sementes de mucuna utilizando diferentes solventesExtração sólido-líquido. Levodopa. Solvente. Mal de Parkinson.Solid-liquid extraction. Levodopa. Solvent. Parkinson’s desease.Levodopa is the main drug currently used to treat Parkinson's disease. This amino acid, found in the mucuna seed, is a direct precursor to dopamine, which acts to reduce and control of disease’s symptoms. The commercially available levodopa is produced synthetically, however, due to the relevance of the topic, studies have been carried out to find alternatives for extracting this compound from natural sources, making the process more economical and sustainable with the use of alternative solvents. In this study, the objective was to characterize the seeds of gray mucuna (Mucuna cinerea) and evaluate the solid-liquid extraction yield of levodopa, using different solvents (benzoic acid, succinic acid, choline chloride, ethanol, PEG 4000 and water). To evaluate which solvents and factors most influenced the extraction yield, a factorial design (23) was carried out. The factors were temperature, extraction time and the ratio between solid and solvent. Composition analysis showed that mucuna is rich in proteins with 26.49% and carbohydrates with 50.63%, has 10.16% minerals, 4.08% lipids and 8.64% moisture. Levodopa was quantified using high-performance liquid chromatography, with an aqueous mixture of water and ethanol 50% m/m being the most suitable solvent for extraction, achieving a yield of 14.14%.A levodopa é a principal droga utilizada atualmente no tratamento da doença de Parkinson. Esse aminoácido, encontrado na semente de mucuna, é um precursor direto da dopamina, que atua na redução e controle dos sintomas da doença. A levodopa comercializada é produzida de forma sintética, no entanto, devido a relevância do tema, estudos têm sido feitos para encontrar alternativas de extração desse composto a partir de fontes naturais, tornando o processo mais econômico e sustentável com o uso de solventes alternativos. Neste estudo, o objetivo foi caracterizar as sementes de mucuna cinza (Mucuna cinerea) e avaliar o rendimento da extração sólido-líquido de levodopa, utilizando diferentes solventes (ácido benzoico, ácido succínico, cloreto de colina, etanol, PEG 4000  e água). Para avaliar quais solventes e fatores que mais influenciavam no rendimento de extração, um delineamento fatorial (23) foi realizado. Os fatores foram a temperatura, tempo de extração e a razão entre sólido e solvente. A análise da composição mostrou que a mucuna é rica em proteínas com 26,49% e carboidratos com 50,63%, tem 10,16% de minerais, 4,08% de lipídeos e 8,64% de umidade. A quantificação da levodopa foi feita por cromatografia líquida de alta eficiência, sendo mistura aquosa de água e etanol 50% m/m o solvente mais indicado para a extração, alcançando o rendimento de 14,14%.Universidade Federal de Viçosa - UFV2024-02-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.ufv.br/jcec/article/view/1821810.18540/jcecvl10iss2pp18218The Journal of Engineering and Exact Sciences; Vol. 10 No. 2 (2024); 18218The Journal of Engineering and Exact Sciences; Vol. 10 Núm. 2 (2024); 18218The Journal of Engineering and Exact Sciences; v. 10 n. 2 (2024); 182182527-1075reponame:Revista de Engenharia Química e Químicainstname:Universidade Federal de Viçosa (UFV)instacron:UFVporhttps://periodicos.ufv.br/jcec/article/view/18218/9416Copyright (c) 2024 The Journal of Engineering and Exact Scienceshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSousa, Rita de Cássia Superbi deQuieli, Giovani da SilvaMonteiro , Thais Pinto CoelhoCosta , Angélica Ribeiro daBenfica, Jordana2024-04-20T19:31:45Zoai:ojs.periodicos.ufv.br:article/18218Revistahttp://www.seer.ufv.br/seer/rbeq2/index.php/req2/indexONGhttps://periodicos.ufv.br/jcec/oaijcec.journal@ufv.br||req2@ufv.br2446-94162446-9416opendoar:2024-04-20T19:31:45Revista de Engenharia Química e Química - Universidade Federal de Viçosa (UFV)false
dc.title.none.fl_str_mv Evaluation of solid-liquid extraction of levodopa from mucuna seeds using different solvents
Evaluación de la extracción sólido-líquido de levodopa a partir de semillas de mucuna utilizando diferentes solventes
Évaluation de l'extraction solide-liquide de la lévodopa à partir de graines de mucuna à l'aide de différents solvants
Avaliação da extração sólido-líquido de levodopa a partir de sementes de mucuna utilizando diferentes solventes
title Evaluation of solid-liquid extraction of levodopa from mucuna seeds using different solvents
spellingShingle Evaluation of solid-liquid extraction of levodopa from mucuna seeds using different solvents
Sousa, Rita de Cássia Superbi de
Extração sólido-líquido. Levodopa. Solvente. Mal de Parkinson.
Solid-liquid extraction. Levodopa. Solvent. Parkinson’s desease.
title_short Evaluation of solid-liquid extraction of levodopa from mucuna seeds using different solvents
title_full Evaluation of solid-liquid extraction of levodopa from mucuna seeds using different solvents
title_fullStr Evaluation of solid-liquid extraction of levodopa from mucuna seeds using different solvents
title_full_unstemmed Evaluation of solid-liquid extraction of levodopa from mucuna seeds using different solvents
title_sort Evaluation of solid-liquid extraction of levodopa from mucuna seeds using different solvents
author Sousa, Rita de Cássia Superbi de
author_facet Sousa, Rita de Cássia Superbi de
Quieli, Giovani da Silva
Monteiro , Thais Pinto Coelho
Costa , Angélica Ribeiro da
Benfica, Jordana
author_role author
author2 Quieli, Giovani da Silva
Monteiro , Thais Pinto Coelho
Costa , Angélica Ribeiro da
Benfica, Jordana
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Sousa, Rita de Cássia Superbi de
Quieli, Giovani da Silva
Monteiro , Thais Pinto Coelho
Costa , Angélica Ribeiro da
Benfica, Jordana
dc.subject.por.fl_str_mv Extração sólido-líquido. Levodopa. Solvente. Mal de Parkinson.
Solid-liquid extraction. Levodopa. Solvent. Parkinson’s desease.
topic Extração sólido-líquido. Levodopa. Solvente. Mal de Parkinson.
Solid-liquid extraction. Levodopa. Solvent. Parkinson’s desease.
description Levodopa is the main drug currently used to treat Parkinson's disease. This amino acid, found in the mucuna seed, is a direct precursor to dopamine, which acts to reduce and control of disease’s symptoms. The commercially available levodopa is produced synthetically, however, due to the relevance of the topic, studies have been carried out to find alternatives for extracting this compound from natural sources, making the process more economical and sustainable with the use of alternative solvents. In this study, the objective was to characterize the seeds of gray mucuna (Mucuna cinerea) and evaluate the solid-liquid extraction yield of levodopa, using different solvents (benzoic acid, succinic acid, choline chloride, ethanol, PEG 4000 and water). To evaluate which solvents and factors most influenced the extraction yield, a factorial design (23) was carried out. The factors were temperature, extraction time and the ratio between solid and solvent. Composition analysis showed that mucuna is rich in proteins with 26.49% and carbohydrates with 50.63%, has 10.16% minerals, 4.08% lipids and 8.64% moisture. Levodopa was quantified using high-performance liquid chromatography, with an aqueous mixture of water and ethanol 50% m/m being the most suitable solvent for extraction, achieving a yield of 14.14%.
publishDate 2024
dc.date.none.fl_str_mv 2024-02-09
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.ufv.br/jcec/article/view/18218
10.18540/jcecvl10iss2pp18218
url https://periodicos.ufv.br/jcec/article/view/18218
identifier_str_mv 10.18540/jcecvl10iss2pp18218
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.ufv.br/jcec/article/view/18218/9416
dc.rights.driver.fl_str_mv Copyright (c) 2024 The Journal of Engineering and Exact Sciences
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2024 The Journal of Engineering and Exact Sciences
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Viçosa - UFV
publisher.none.fl_str_mv Universidade Federal de Viçosa - UFV
dc.source.none.fl_str_mv The Journal of Engineering and Exact Sciences; Vol. 10 No. 2 (2024); 18218
The Journal of Engineering and Exact Sciences; Vol. 10 Núm. 2 (2024); 18218
The Journal of Engineering and Exact Sciences; v. 10 n. 2 (2024); 18218
2527-1075
reponame:Revista de Engenharia Química e Química
instname:Universidade Federal de Viçosa (UFV)
instacron:UFV
instname_str Universidade Federal de Viçosa (UFV)
instacron_str UFV
institution UFV
reponame_str Revista de Engenharia Química e Química
collection Revista de Engenharia Química e Química
repository.name.fl_str_mv Revista de Engenharia Química e Química - Universidade Federal de Viçosa (UFV)
repository.mail.fl_str_mv jcec.journal@ufv.br||req2@ufv.br
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